INT4913

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Context Info
Confidence 0.28
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 52
Total Number 53
Disease Relevance 9.57
Pain Relevance 42.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pax3) nucleus (Pax3) DNA binding (Pax3)
Anatomy Link Frequency
spinal cord 4
brain 2
macrophages 1
hepatocytes 1
interneurons 1
Pax3 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 4951 100.00 Very High Very High Very High
Neuropeptide 163 100.00 Very High Very High Very High
Calcitonin gene-related peptide 71 100.00 Very High Very High Very High
Pain 51 100.00 Very High Very High Very High
Analgesic 20 100.00 Very High Very High Very High
Enkephalin 68 99.80 Very High Very High Very High
mu opioid receptor 4 99.76 Very High Very High Very High
Spinal cord 77 99.68 Very High Very High Very High
Dorsal horn neuron 6 99.00 Very High Very High Very High
opiate 4 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 48 100.00 Very High Very High Very High
Immunization 12 100.00 Very High Very High Very High
Schistosomiasis 6 99.80 Very High Very High Very High
Glucose Metabolism Disorders 2 99.40 Very High Very High Very High
Targeted Disruption 142 99.38 Very High Very High Very High
Nociception 61 99.16 Very High Very High Very High
Granuloma 284 98.84 Very High Very High Very High
Apoptosis 6 98.04 Very High Very High Very High
Hyperalgesia 5 97.48 Very High Very High Very High
Necrosis 6 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because sub-nanomolar concentrations of SP or N-terminal SP fragments displaced [3H] DAGO binding to a minor but detectable degree, it is suggested that SP interacts with mu 1 sites through its N-terminus portion.
SP Binding (binding) of associated with substance p
1) Confidence 0.28 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2473408 Disease Relevance 0 Pain Relevance 1.20
The effect of SP on DAGO binding was less in the spinal cord compared to the rest of the brain.
SP Binding (binding) of in brain associated with spinal cord and substance p
2) Confidence 0.28 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2473408 Disease Relevance 0 Pain Relevance 1.18
The objective was to determine whether SP exerts its analgesic effect by interacting with mu opioid receptors.
SP Binding (interacting) of associated with analgesic, mu opioid receptor and substance p
3) Confidence 0.28 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2473408 Disease Relevance 0 Pain Relevance 1.01
Because sub-nanomolar concentrations of SP or N-terminal SP fragments displaced [3H] DAGO binding to a minor but detectable degree, it is suggested that SP interacts with mu 1 sites through its N-terminus portion.
SP Binding (binding) of associated with substance p
4) Confidence 0.28 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2473408 Disease Relevance 0 Pain Relevance 1.20
By following internalization of the SP receptor in spinal cord dorsal horn neurons, we have identified the stimuli that evoke SP release and the neurons that respond to these stimuli.
SP Binding (internalization) of in neurons associated with dorsal horn neuron, spinal cord and substance p
5) Confidence 0.27 Published 1999 Journal Reg Anesth Pain Med Section Abstract Doc Link 9952097 Disease Relevance 0.70 Pain Relevance 0.78
Pretreatment with [D-Pro2,D-Phe7]SP(1-7), an inhibitor of SP NH2-terminal binding, blocked the potentiative effect of SP(1-7) as well as the sensitization to repeated injections of KA.
SP Binding (binding) of associated with substance p
6) Confidence 0.18 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1281498 Disease Relevance 0 Pain Relevance 0.98
The present investigation was initiated to determine whether N-terminal fragments interact at binding sites distinct from the neurokinin-1 (NK-1) receptor where the C-terminal sequence of SP binds with high affinity, and distinct from mu-opiate receptors, where we have previously shown the N-terminal sequence of SP to interact.
SP Binding (binds) of associated with opiate and substance p
7) Confidence 0.18 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1700082 Disease Relevance 0 Pain Relevance 0.76
However, injection of 1 nmol of SP(1-7) decreased the Bmax of [3H]SP binding in the spinal cord at 6 h after its injection just as this dose of SP decreased the Bmax at 24 h.
SP Binding (binding) of in spinal cord associated with spinal cord and substance p
8) Confidence 0.17 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7529387 Disease Relevance 0 Pain Relevance 1.20
Injection of SP(5-11) intrathecally did not affect the affinity (Kd) or concentration (Bmax) of [3H]SP binding.
SP Binding (binding) of associated with substance p
9) Confidence 0.17 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7529387 Disease Relevance 0 Pain Relevance 1.20
As SP(5-11) did not down-regulate NK-1 binding, activation of NK-1 sites does not appear necessary or sufficient for down-regulation of SP binding.
SP Binding (binding) of associated with substance p
10) Confidence 0.17 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7529387 Disease Relevance 0 Pain Relevance 1.11
Binding of [3H]SP to mouse spinal cord membranes was inhibited by SP, CP-96,345, and to a lesser extent by SP(5-11), but not SP(1-7), consistent with these binding sites being NK-1 receptors.
SP Binding (Binding) of in spinal cord associated with spinal cord and substance p
11) Confidence 0.17 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7529387 Disease Relevance 0 Pain Relevance 1.09
In contrast, SP(1-7), in spite of its inability to interact with NK-1 sites, did down-regulate SP binding, suggesting an indirect mechanism dissociated from NK-1 receptors.
SP Binding (binding) of associated with substance p
12) Confidence 0.17 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7529387 Disease Relevance 0 Pain Relevance 1.06
The binding site for 3H-SP(1-7) appeared to be a membrane-bound complex whose specific binding was dependent on the integrity of both proteins and phospholipids.
SP Spec (appeared) Binding (binding) of associated with substance p
13) Confidence 0.15 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1700082 Disease Relevance 0 Pain Relevance 0.88
Specific binding of substance P aminoterminal heptapeptide [SP(1-7)] to mouse brain and spinal cord membranes.
SP Binding (binding) of in spinal cord associated with spinal cord and substance p
14) Confidence 0.15 Published 1990 Journal J. Neurosci. Section Title Doc Link 1700082 Disease Relevance 0 Pain Relevance 0.75
The goals of the present study were (1) to determine whether desensitization also develops to the CBS behavior produced by EAAs in the spinal cord, (2) to characterize the role of interneurons in desensitization, and (3) to examine possible interactions between EAAs and SP.
SP Binding (interactions) of in interneurons associated with substance p and spinal cord
15) Confidence 0.13 Published 1991 Journal J. Neurosci. Section Abstract Doc Link 1719157 Disease Relevance 0 Pain Relevance 0.49
Substance P (SP), a neuropeptide and pain transmitter, is associated with the gastrointestinal tract and is elevated in humans and macaques after experimental C. parvum challenge.
SP Binding (associated) of associated with pain, neuropeptide and substance p
16) Confidence 0.13 Published 2008 Journal J. Parasitol. Section Abstract Doc Link 18576802 Disease Relevance 1.12 Pain Relevance 0.44
Granuloma formation in response to murine schistosomiasis requires binding of SP to its specific receptor [30].
SP Binding (binding) of associated with granuloma, schistosomiasis and substance p
17) Confidence 0.12 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817809 Disease Relevance 2.04 Pain Relevance 0.51
They hypothesized that the SP-driven feed-forward inhibition may serve to balance neuronal activity by counteracting SP-mediated excitatory nociceptive responses.
SP Binding (counteracting) of in neuronal associated with nociception and substance p
18) Confidence 0.11 Published 2005 Journal Mol Pain Section Body Doc Link PMC1315348 Disease Relevance 0.27 Pain Relevance 1.06
The final targets for the signaling pathway initiated by SP binding to NK1R to result in SP-driven feed-forward inhibition in the spinal cord dorsal horn are still a mystery. (3) Although SP and NKA are synthesized together, they affect spinal nociception in different ways [24, 25].
SP Binding (binding) of in spinal cord dorsal horn associated with nociception, dorsal horn, spinal cord and substance p
19) Confidence 0.10 Published 2005 Journal Mol Pain Section Body Doc Link PMC1315348 Disease Relevance 0.09 Pain Relevance 0.70
Therefore, it may be possible that in the NK1-knockout mice, the synergistic lack of activity of both SP and hemokinin may have resulted in lower IL-1?
SP Binding (activity) of associated with targeted disruption and substance p
20) Confidence 0.09 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817809 Disease Relevance 1.52 Pain Relevance 0.55

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