INT49134

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Context Info
Confidence 0.78
First Reported 1993
Last Reported 2010
Negated 5
Speculated 15
Reported most in Abstract
Documents 270
Total Number 285
Disease Relevance 84.78
Pain Relevance 148.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
spinal cord 28
neurons 19
spinal 11
brain 6
striatum 6
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 2949 100.00 Very High Very High Very High
Spinal cord 890 100.00 Very High Very High Very High
Glutamate 661 100.00 Very High Very High Very High
antagonist 582 100.00 Very High Very High Very High
Glutamate receptor 276 100.00 Very High Very High Very High
Neurotransmitter 123 100.00 Very High Very High Very High
Kinase C 85 100.00 Very High Very High Very High
opioid receptor 23 100.00 Very High Very High Very High
Kappa opioid receptor 10 100.00 Very High Very High Very High
sodium channel 6 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 99 99.98 Very High Very High Very High
Colitis 583 99.90 Very High Very High Very High
Pain 456 99.82 Very High Very High Very High
Neuropathic Pain 523 99.72 Very High Very High Very High
Stress 192 99.72 Very High Very High Very High
INFLAMMATION 1331 99.70 Very High Very High Very High
Nociception 700 99.68 Very High Very High Very High
Dyspepsia 300 99.68 Very High Very High Very High
Schizophrenia 157 99.60 Very High Very High Very High
Teratocarcinoma 3 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibitory effects of Group I metabotropic glutamate receptors antagonists on the expression of NMDA receptor NR1 subunit in morphine tolerant rats.
Gene_expression (expression) of NR1 subunit associated with nmda receptor, antagonist, glutamate receptor and morphine
1) Confidence 0.78 Published 2009 Journal Neurosci. Lett. Section Title Doc Link 19348736 Disease Relevance 0 Pain Relevance 1.54
These findings suggest that the development of morphine tolerance partly prevented by Group I mGluRs antagonists may due to its inhibitory effect on the expression of NR1 subunit.
Gene_expression (expression) of NR1 subunit associated with antagonist, tolerance and morphine
2) Confidence 0.78 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19348736 Disease Relevance 0 Pain Relevance 1.57
The aim of the present study was to examine the influence of Group I mGluRs antagonists on the expression of NMDA receptor NR1 subunit (NR1) in the rat spinal cord.
Gene_expression (expression) of NR1 subunit in spinal cord associated with nmda receptor, antagonist and spinal cord
3) Confidence 0.78 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19348736 Disease Relevance 0 Pain Relevance 1.26
The expression of NR1 was upregulated in the dorsal horn of spinal cord after chronic morphine treatment.
Gene_expression (expression) of NR1 in spinal cord associated with dorsal horn, morphine and spinal cord
4) Confidence 0.78 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19348736 Disease Relevance 0 Pain Relevance 1.74
The aim of the present study was to examine the influence of Group I mGluRs antagonists on the expression of NMDA receptor NR1 subunit (NR1) in the rat spinal cord.
Gene_expression (expression) of NR1 in spinal cord associated with nmda receptor, antagonist and spinal cord
5) Confidence 0.78 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19348736 Disease Relevance 0 Pain Relevance 1.27
The expression of NR1 was measured by immunofluorescence and Western blot.
Gene_expression (expression) of NR1
6) Confidence 0.78 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19348736 Disease Relevance 0 Pain Relevance 1.72
We studied the influence of acute and repeated morphine (20 mg/kg i.p. or increasing dose for 10 days) and cocaine (3x20 mg/kg i.p. per day at hourly intervals, for 1 or 5 days) administration on the expression of glutamate NMDA receptor subunit 1 (NMDAR1) in the central and basolateral nuclei of the rat amygdala and hippocampal formation.
Gene_expression (expression) of glutamate NMDA receptor subunit 1 in hippocampal formation associated with glutamate, nmda receptor, amygdala, cocaine and morphine
7) Confidence 0.78 Published 2003 Journal Drug Alcohol Depend Section Abstract Doc Link 14636974 Disease Relevance 0.09 Pain Relevance 0.89
The effect of drugs of abuse on NMDAR1 receptor expression in the rat limbic system.
Gene_expression (expression) of NMDAR1 associated with limbic system
8) Confidence 0.78 Published 2003 Journal Drug Alcohol Depend Section Title Doc Link 14636974 Disease Relevance 0.09 Pain Relevance 1.03
Our study suggests a possible link between the expression of NMDAR1 and changes in limbic system neuronal activity and behaviour after administration of morphine and cocaine.
Gene_expression (expression) of NMDAR1 in neuronal associated with limbic system, cocaine and morphine
9) Confidence 0.78 Published 2003 Journal Drug Alcohol Depend Section Abstract Doc Link 14636974 Disease Relevance 0.07 Pain Relevance 1.23
We studied the influence of acute and repeated morphine (20 mg/kg i.p. or increasing dose for 10 days) and cocaine (3x20 mg/kg i.p. per day at hourly intervals, for 1 or 5 days) administration on the expression of glutamate NMDA receptor subunit 1 (NMDAR1) in the central and basolateral nuclei of the rat amygdala and hippocampal formation.
Gene_expression (expression) of NMDAR1 in hippocampal formation associated with glutamate, nmda receptor, amygdala, cocaine and morphine
10) Confidence 0.78 Published 2003 Journal Drug Alcohol Depend Section Abstract Doc Link 14636974 Disease Relevance 0.09 Pain Relevance 0.90
In summary, the present study demonstrated that morphine and cocaine influenced the expression of NMDAR1 in the structure of the limbic system which could be involved in dependence phenomena.
Gene_expression (expression) of NMDAR1 associated with addiction, limbic system, cocaine and morphine
11) Confidence 0.78 Published 2003 Journal Drug Alcohol Depend Section Abstract Doc Link 14636974 Disease Relevance 0.06 Pain Relevance 1.18
In addition, the elevation of NR1 expression by morphine was decreased by the coadministration of nalbuphine in rat cortex.
Gene_expression (expression) of NR1 in cortex associated with nalbuphine and morphine
12) Confidence 0.78 Published 2006 Journal Arch. Pharm. Res. Section Abstract Doc Link 16964763 Disease Relevance 0.32 Pain Relevance 2.55
In this study, the authors examined the effect of subcutaneous injection of siRNA targeting the NR1 subunit of the N-methyl-D-aspartate receptor on silencing NR1 gene expression and subsequently abolishing inflammatory nociception in rats.
Gene_expression (expression) of NR1 associated with nociception, inflammation and nmda receptor
13) Confidence 0.78 Published 2010 Journal Anesthesiology Section Abstract Doc Link 20463582 Disease Relevance 0.43 Pain Relevance 0.38
The antinociception effect and the inhibition of NR1 expression persisted for about 7 days after administration of NR1 siRNA.
Gene_expression (expression) of NR1
14) Confidence 0.78 Published 2010 Journal Anesthesiology Section Body Doc Link 20463582 Disease Relevance 0.15 Pain Relevance 0
These findings suggest that excitotoxic lesions of the spinal cord induce both NR1 expression and NR1 serine phosphorylation.
Gene_expression (expression) of NR1 in spinal cord associated with spinal cord
15) Confidence 0.78 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12946581 Disease Relevance 0.23 Pain Relevance 0.29
The purpose of this study therefore was to determine whether dopamine depletion differentially alters the expression of the 2A subunit of the N-methyl-D-aspartate receptor in rat striatal neurons. 6-Hydroxydopamine (8microg/2microl) was infused unilaterally into the medial forebrain bundle.
Gene_expression (expression) of N-methyl-D-aspartate receptor in medial forebrain bundle associated with dopamine and nmda receptor
16) Confidence 0.78 Published 2001 Journal Neuroscience Section Abstract Doc Link 11246155 Disease Relevance 0 Pain Relevance 0.57
Unilateral dopamine depletion increases expression of the 2A subunit of the N-methyl-D-aspartate receptor in enkephalin-positive and enkephalin-negative neurons.
Gene_expression (expression) of N-methyl-D-aspartate receptor in neurons associated with dopamine, nmda receptor and enkephalin
17) Confidence 0.78 Published 2001 Journal Neuroscience Section Title Doc Link 11246155 Disease Relevance 0 Pain Relevance 0.73
From this study we conclude that dopamine depletion increases messenger RNA expression of the 2A subunit of the N-methyl-D-aspartate receptor in striatopallidal and presumed striatonigral (enkephalin-negative) neurons.
Gene_expression (expression) of N-methyl-D-aspartate receptor in neurons associated with dopamine, nmda receptor and enkephalin
18) Confidence 0.78 Published 2001 Journal Neuroscience Section Abstract Doc Link 11246155 Disease Relevance 0 Pain Relevance 0.90
Previous work has also reported increased expression of the 2A subunit of the N-methyl-D-aspartate receptor in the dopamine-depleted striatum.
Gene_expression (expression) of N-methyl-D-aspartate receptor in striatum associated with dopamine and nmda receptor
19) Confidence 0.78 Published 2001 Journal Neuroscience Section Abstract Doc Link 11246155 Disease Relevance 0 Pain Relevance 0.55
Immunoblot analysis showed an antisense-concentration-dependent reduction in the NR1 subunit upon transient co-transfection of a plasmid expressing a sense NR1 gene and a plasmid expressing the antisense fragment into COS-7 cells.
Gene_expression (expressing) of NR1
20) Confidence 0.78 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11376852 Disease Relevance 0.08 Pain Relevance 0.16

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