INT49139

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Context Info
Confidence 0.68
First Reported 1994
Last Reported 2004
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.74
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
neurons 2
lung 2
Tac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 13 99.80 Very High Very High Very High
qutenza 22 98.88 Very High Very High Very High
cytokine 2 95.52 Very High Very High Very High
Inflammation 1 92.32 High High
Sciatic nerve 1 87.72 High High
Eae 1 86.88 High High
Inflammatory response 4 77.72 Quite High
c fibre 3 75.48 Quite High
Neuropathic pain 1 75.00 Quite High
Root ganglion neuron 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 10 99.98 Very High Very High Very High
Hypertension 3 97.96 Very High Very High Very High
Injury 2 97.64 Very High Very High Very High
Neurogenic Inflammation 1 92.32 High High
INFLAMMATION 4 77.32 Quite High
Nervous System Injury 1 75.28 Quite High
Neuropathic Pain 2 75.00 Quite High
Ganglion Cysts 1 75.00 Quite High
Asthma 1 67.60 Quite High
Causalgia 1 60.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Injury-induced changes in PPT mRNA expression by affected DRG neurons included: (1) at early postoperative times, generally increased levels of PPT mRNA associated with small and intermediate-size B cells exhibiting normal morphology, (2) at late postoperative times, markedly decreased levels of PPT mRNA associated with degenerating B cells, and (3) induction of PPT gene expression by large A cells which is highly correlated with degenerative morphological changes.
Positive_regulation (increased) of Positive_regulation (levels) of PPT mRNA in neurons associated with injury
1) Confidence 0.68 Published 1994 Journal Pain Section Abstract Doc Link 7816489 Disease Relevance 0.47 Pain Relevance 0.30
These results suggest that the chronic hypoxia causes an increase in lung tachykinin levels which, in turn, enhance the development of pulmonary hypertension.
Positive_regulation (causes) of Positive_regulation (increase) of tachykinin in lung associated with hypoxia and hypertension
2) Confidence 0.45 Published 1995 Journal Respir Physiol Section Abstract Doc Link 7539934 Disease Relevance 0.83 Pain Relevance 0.65
LPS induced significant increases in PPT mRNA and SP levels in vitro and in vivo and an increase in airway reactivity to capsaicin in vivo.
Positive_regulation (induced) of Positive_regulation (increases) of PPT mRNA associated with qutenza and substance p
3) Confidence 0.37 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14613715 Disease Relevance 0.07 Pain Relevance 0.41
In addition, except for SP release, SSCS exposure significantly induced the tachykininergic toxicities at the gene level: upregulation of beta-preprotachykinin-I (beta-PPT-I) mRNA.
Neg (except) Positive_regulation (induced) of Positive_regulation (upregulation) of beta-PPT-I associated with substance p
4) Confidence 0.08 Published 2004 Journal Toxicology Section Abstract Doc Link 15297018 Disease Relevance 0.37 Pain Relevance 0.87

General Comments

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