INT49141

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Context Info
Confidence 0.78
First Reported 1995
Last Reported 2010
Negated 5
Speculated 0
Reported most in Body
Documents 157
Total Number 157
Disease Relevance 85.22
Pain Relevance 24.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Selp) cell adhesion (Selp) nucleus (Selp)
cytoplasm (Selp)
Anatomy Link Frequency
platelet 53
leukocyte 9
joints 6
endothelial cell 5
endothelium 5
Selp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1344 100.00 Very High Very High Very High
Arthritis 1045 100.00 Very High Very High Very High
Inflammatory response 277 99.92 Very High Very High Very High
agonist 190 99.84 Very High Very High Very High
Pain 34 99.74 Very High Very High Very High
Angina 96 99.68 Very High Very High Very High
antinociception 9 99.40 Very High Very High Very High
chemokine 289 99.36 Very High Very High Very High
Inflammatory stimuli 16 99.36 Very High Very High Very High
cINOD 31 99.34 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1631 100.00 Very High Very High Very High
Arthritis 1164 100.00 Very High Very High Very High
Adhesions 826 100.00 Very High Very High Very High
Metabolic Syndrome 23 99.84 Very High Very High Very High
Atherosclerosis 62 99.82 Very High Very High Very High
Pain 26 99.74 Very High Very High Very High
Cv General 3 Under Development 446 99.68 Very High Very High Very High
Multiple Sclerosis 159 99.68 Very High Very High Very High
Sepsis 406 99.60 Very High Very High Very High
Viral Meningitis 3 99.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found faster V(RBC) of sickle RBCs in P-selectin knock-out and control mice than in sickle cell mice, which have increased endothelial cell P-selectin expression.
Gene_expression (expression) of P-selectin in endothelial cell associated with sickle cell anemia and targeted disruption
1) Confidence 0.78 Published 2004 Journal Blood Section Abstract Doc Link 15271798 Disease Relevance 0.43 Pain Relevance 0.12
CD62p expression was also evaluated in 30 normal control subjects.
Gene_expression (expression) of CD62p
2) Confidence 0.77 Published 2005 Journal Circ. J. Section Body Doc Link 16195618 Disease Relevance 0.09 Pain Relevance 0
CD62p expression was markedly higher pre-procedure in the study patients than in the normal control subjects (5.2+/-4.0% vs 1.4+/-0.6%, p<0.0001).
Gene_expression (expression) of CD62p
3) Confidence 0.77 Published 2005 Journal Circ. J. Section Body Doc Link 16195618 Disease Relevance 0.09 Pain Relevance 0
CD62p expression in the study patients remained significantly higher at 24 h after the procedure than in the control subjects (3.8+/-2.1% vs 1.4+/-0.6%, p<0.001).
Gene_expression (expression) of CD62p
4) Confidence 0.77 Published 2005 Journal Circ. J. Section Body Doc Link 16195618 Disease Relevance 0.08 Pain Relevance 0
Of these, increased expression of P-selectin, ICAM-1 and CCL12 after carrageenan injection could be verified by real-time RT-PCR on both the right and left sides, and increased in P-selectin and ICAM-1 further verified by Western blot analysis.
Gene_expression (expression) of P-selectin
5) Confidence 0.75 Published 2009 Journal Pain Section Abstract Doc Link 19167818 Disease Relevance 0.58 Pain Relevance 0.44
There were no significant differences on CD62P expression of platelets between control and antibody groups before CPB (105 +/- 12% vs. 99 +/- 8%, P=NS), during normothermic CPB (62 +/- 6% vs. 63 +/- 19%, P=NS), during hypothermic CPB (55 +/- 8% vs. 54 +/- 13%, P=NS), and 1, 3, or 6 h after CPB (74 +/- 20% vs. 81 +/- 11%, P=NS).
Gene_expression (expression) of CD62P in platelets
6) Confidence 0.72 Published 2004 Journal Artif Organs Section Abstract Doc Link 15385005 Disease Relevance 0.09 Pain Relevance 0.33
Incubation with TRAP significantly and maximally increased P-selectin and microparticle expression compared with baseline values of unstimulated platelets (Figures 1 and 2).
Gene_expression (expression) of P-selectin in platelets
7) Confidence 0.72 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.23 Pain Relevance 0.03
2a adrenergic receptors, in turn, could activate circulating platelets as reflected by surface expression of CD62P (P-selectin), conformational changes of the GPIIb/IIIa receptor, shedding of platelet-derived microparticles [3,4], and soluble adhesion molecules (sP-selectin).
Gene_expression (expression) of P-selectin in platelet associated with adhesions
8) Confidence 0.72 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.24 Pain Relevance 0
In those 8 patients with pneumonia and the single patient with bacteremia, there was no significant difference in baseline P-selectin expression and susceptibility to norepinephrine-mediated stimulation of isolated platelets compared with the remaining 5 patients.
Gene_expression (expression) of P-selectin in platelets associated with bacteremia and pneumonia
9) Confidence 0.72 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.73 Pain Relevance 0.35
The preserved functionality in platelets despite decreased baseline P-selectin expression as found in the second week is in line with results from Michelson and colleagues [18], who showed that circulating platelets remain active for at least 24 hours following shedding of surface P-selectin.
Gene_expression (expression) of P-selectin in platelets
10) Confidence 0.72 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.07 Pain Relevance 0
Thus, decreased baseline P-selectin expression observed in the second week does not appear to be induced by HES since patients required significantly less HES 130/0.4 compared with the first week.
Gene_expression (expression) of P-selectin
11) Confidence 0.72 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.36 Pain Relevance 0.07
In fact, baseline P-selectin and microparticle expression were comparable to healthy volunteers during the first week despite a significantly larger amount of HES 130/0.4 administered per day compared with the single administration of HES 130/0.4 during minor surgery as studied by Chen and colleagues [35].


Gene_expression (expression) of P-selectin
12) Confidence 0.72 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.37 Pain Relevance 0.07
While P-selectin expression determines size and stability of platelet aggregates [19], reduced surface P-selectin expression does not imply functional impairment [18].
Gene_expression (expression) of P-selectin in platelet
13) Confidence 0.72 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0 Pain Relevance 0
As reported by Chen and colleagues [35], HES 130/0.4 (VoluvenĀ®, which is routinely used in our ICU, induced transient reduction in platelet-mediated coagulation reflected by decreased platelet membrane glycoprotein and P-selectin expression in patients undergoing elective minor surgery.
Gene_expression (expression) of P-selectin in platelet
14) Confidence 0.72 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.39 Pain Relevance 0.14
During the second post-traumatic week, the number of P-selectin-positive cells expressed as the relative amount of all gated platelets was significantly reduced compared with healthy controls and the first week (Figure 3).
Gene_expression (expressed) of P-selectin in platelets
15) Confidence 0.72 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.35 Pain Relevance 0.03
We conclude that endothelial cell P-selectin contributes to the microcirculatory abnormalities in sickle cell disease and that blocking P-selectin may be useful for preventing painful vasoocclusion in sickle cell disease.
Gene_expression (contributes) of P-selectin in endothelial cell associated with sickle cell anemia, pain and congenital anomalies
16) Confidence 0.67 Published 2004 Journal Blood Section Abstract Doc Link 15271798 Disease Relevance 0.64 Pain Relevance 0.22
METHODS AND RESULTS: Platelet activation (expressed by CD62p) was serially examined using flow cytometry in 42 consecutive patients with UA who underwent coronary stenting.
Gene_expression (expressed) of CD62p in Platelet
17) Confidence 0.67 Published 2005 Journal Circ. J. Section Body Doc Link 16195618 Disease Relevance 0.10 Pain Relevance 0
[Detection of CD62P (GMP-140) on peripheral blood platelet membrane in various heart diseases].
Gene_expression (Detection) of CD62P in heart associated with heart disease
18) Confidence 0.65 Published 1995 Journal Rinsho Byori Section Title Doc Link 7540229 Disease Relevance 0.46 Pain Relevance 0.07
The protein CD62P expressed on platelet surface membrane was measured by flow cytometry to evaluate its clinical significance.
Gene_expression (expressed) of CD62P in platelet
19) Confidence 0.65 Published 1995 Journal Rinsho Byori Section Abstract Doc Link 7540229 Disease Relevance 0.16 Pain Relevance 0
While P-selectin expression determines size and stability of platelet aggregates [19], reduced surface P-selectin expression does not imply functional impairment [18].
Gene_expression (expression) of P-selectin in platelet
20) Confidence 0.62 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0 Pain Relevance 0

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