INT49142

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Context Info
Confidence 0.75
First Reported 1995
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 94
Total Number 97
Disease Relevance 54.61
Pain Relevance 11.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SELP) cell adhesion (SELP) nucleolus (SELP)
plasma membrane (SELP) nucleus (SELP) cytoplasm (SELP)
Anatomy Link Frequency
platelets 50
endothelial cells 5
leukocyte 4
plasma 2
endothelium 2
SELP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 499 100.00 Very High Very High Very High
aspirin 455 99.84 Very High Very High Very High
rheumatoid arthritis 132 99.84 Very High Very High Very High
Delta-9-tetrahydrocannabinol 18 99.70 Very High Very High Very High
diclofenac 6 99.06 Very High Very High Very High
metalloproteinase 40 98.52 Very High Very High Very High
Cannabinoid receptor 8 98.44 Very High Very High Very High
sSRI 5 98.00 Very High Very High Very High
Angina 111 97.54 Very High Very High Very High
5HT 23 96.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 1377 100.00 Very High Very High Very High
INFLAMMATION 589 100.00 Very High Very High Very High
Cancer 174 100.00 Very High Very High Very High
Necrosis 18 100.00 Very High Very High Very High
Nicotine Addiction 1110 99.84 Very High Very High Very High
Rheumatoid Arthritis 133 99.84 Very High Very High Very High
Heart Rate Under Development 379 99.80 Very High Very High Very High
Endometriosis 11 99.80 Very High Very High Very High
Stress 79 99.64 Very High Very High Very High
Pancreatitis 21 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Detection of CD62P (GMP-140) on peripheral blood platelet membrane in various heart diseases].
Gene_expression (Detection) of GMP-140 in heart associated with heart disease
1) Confidence 0.75 Published 1995 Journal Rinsho Byori Section Title Doc Link 7540229 Disease Relevance 0.46 Pain Relevance 0.07
In a recent study it was demonstrated that EDTA, used as the blood anticoagulant, brought about a significant increase in expression of GMP-140 antigen, and this effect was accompanied by a significant increase in platelet MLF.
Gene_expression (expression) of GMP-140 in platelet
2) Confidence 0.75 Published 1998 Journal Platelets Section Abstract Doc Link 16793756 Disease Relevance 0 Pain Relevance 0
Platelet activation markers for ex vivo analysis may include a) activation-dependent epitopes of the membrane glycoprotein (GP) IIb/IIIa (CD41a) receptor, as demonstrated by the binding of activation-specific monoclonal antibodies (MoAbs) PAC1, anti-LIBS1 and anti-RIBS); b) the expression of P-selectin (CD62p), the alpha-granule GP translocated to the platelet surface following release reaction; and c) platelet procoagulant activity, as demonstrated by the binding of i) annexin V protein to the prothrombinase-complex (prothrombin, activated factor X (Xa) and V (Va)) binding sites on the surface of activated platelets, and of ii) MoAbs against activated coagulation factors V and X bound to the surface of activated platelets.
Gene_expression (expression) of CD62p in platelets
3) Confidence 0.75 Published 2004 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 15471223 Disease Relevance 0 Pain Relevance 0
The aim of this study was to investigate the expression of E- and P-selectins in endometriotic tissues and the corresponding endometria.
Spec (investigate) Gene_expression (expression) of P-selectin associated with endometriosis
4) Confidence 0.75 Published 2000 Journal Gynecol. Endocrinol. Section Abstract Doc Link 10836198 Disease Relevance 1.12 Pain Relevance 0.30
Measurements were performed for (1) platelet surface activation, assessing flow cytometric expression of activated integrin alpha(IIb)beta(3) receptor (GPIIb/IIIa, CD41a) and P-selectin (CD62p); (2) platelet and erythrocyte surface procoagulant activities, measuring flow cytometric binding of activated factor (FVa) and annexin V; (3) plasma levels of platelet-specific secreted proteins platelet factor 4 (PF4) and beta-thromboglobulin (betaTG); (4) plasma markers of thrombin generation, prothrombin activation fragment (F(1.2)), and thrombin: antithrombin complex (TAT); and (5) plasma markers of fibrinolysis, D -dimer, and plasmin:antiplasmin complex (PAP).
Gene_expression (expression) of CD62p in plasma
5) Confidence 0.75 Published 2001 Journal J. Lab. Clin. Med. Section Abstract Doc Link 11385360 Disease Relevance 0.49 Pain Relevance 0.18
Platelet activation markers for ex vivo analysis may include a) activation-dependent epitopes of the membrane glycoprotein (GP) IIb/IIIa (CD41a) receptor, as demonstrated by the binding of activation-specific monoclonal antibodies (MoAbs) PAC1, anti-LIBS1 and anti-RIBS); b) the expression of P-selectin (CD62p), the alpha-granule GP translocated to the platelet surface following release reaction; and c) platelet procoagulant activity, as demonstrated by the binding of i) annexin V protein to the prothrombinase-complex (prothrombin, activated factor X (Xa) and V (Va)) binding sites on the surface of activated platelets, and of ii) MoAbs against activated coagulation factors V and X bound to the surface of activated platelets.
Gene_expression (expression) of P-selectin in platelets
6) Confidence 0.75 Published 2004 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 15471223 Disease Relevance 0 Pain Relevance 0
These areas presented considerably increased endothelial P-selectin expression with adherent, oxygen free radical-producing polymorphonuclear leukocytes displaying pericellular cerium-reflectance.
Gene_expression (expression) of P-selectin in polymorphonuclear leukocytes
7) Confidence 0.74 Published 2001 Journal Hepatogastroenterology Section Abstract Doc Link 11677940 Disease Relevance 1.13 Pain Relevance 0.05
We have noted P-selectin overexpression with a preponderance in the areas of acinar oxidative stress.
Gene_expression (overexpression) of P-selectin associated with stress
8) Confidence 0.74 Published 2001 Journal Hepatogastroenterology Section Abstract Doc Link 11677940 Disease Relevance 1.01 Pain Relevance 0
The control pancreas specimen showed minimal oxidative stress with weak, focal P-selectin expression.
Gene_expression (expression) of P-selectin in pancreas associated with stress
9) Confidence 0.74 Published 2001 Journal Hepatogastroenterology Section Abstract Doc Link 11677940 Disease Relevance 1.01 Pain Relevance 0
RESULTS: AA, ADP, and TRAP-6 markedly increased the expression of CD62P on platelets, whereas CD42b (shedding) and PAC-1 (heterotypic conjugates) expression decreased.
Gene_expression (expression) of CD62P in platelets
10) Confidence 0.73 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18499605 Disease Relevance 0 Pain Relevance 0
Low-dose sevoflurane inhalation reduced ADP-induced CD62P expression on platelets 24 h after inhalation, and inhibited the formation of granulocyte-platelet aggregates under stimulation with AA and ADP after 1 and 24 h, and with TRAP-6 after 24 h compared with control.
Gene_expression (expression) of CD62P in granulocyte
11) Confidence 0.73 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18499605 Disease Relevance 0 Pain Relevance 0
Moreover, immunocytofluorimetry demonstrated that diclofenac dose-dependently (100-500 microM) induced the expression of GMP-140 and increased the expression of GPIIb/IIIa on the membrane of unstimulated platelets.
Gene_expression (expression) of GMP-140 in platelets associated with diclofenac
12) Confidence 0.71 Published 1996 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 8735806 Disease Relevance 0.48 Pain Relevance 0.24
High doses ( > 500 microM) of this drug inhibited thrombin-stimulated expression of GPIIb/IIIa and GMP-140.
Gene_expression (expression) of GMP-140
13) Confidence 0.71 Published 1996 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 8735806 Disease Relevance 0.44 Pain Relevance 0.23
We measured various platelet activation markers including expressions of PAC-1 and P-selectin, annexin V binding, and microparticle formations by means of whole-blood flow cytometry.
Gene_expression (expressions) of P-selectin in platelet
14) Confidence 0.71 Published 2003 Journal J. Thorac. Cardiovasc. Surg. Section Body Doc Link 12928640 Disease Relevance 0 Pain Relevance 0
The direct thrombin inhibitor argatroban prevented platelet loss and expression of P-selectin significantly more than did heparin.
Gene_expression (expression) of P-selectin in platelet
15) Confidence 0.71 Published 2003 Journal J. Thorac. Cardiovasc. Surg. Section Body Doc Link 12928640 Disease Relevance 0 Pain Relevance 0
These antagonists significantly suppressed but did not abolish P-selectin expression, annexin V binding, and microparticle formation.
Gene_expression (expression) of P-selectin
16) Confidence 0.71 Published 2003 Journal J. Thorac. Cardiovasc. Surg. Section Body Doc Link 12928640 Disease Relevance 0 Pain Relevance 0
Leptin, and vascular adhesion markers (soluble-Intercellular Adhesion Molecule-1, soluble-Vascular Cell Adhesion Molecule-1, soluble P-Selectin, soluble E-Selectin), and soluble CD40 ligand were measured using a commercially available enzyme-linked immunosorbent assay (ELISA) kits (leptin, adhesion markers: R&D Systems, Minneapolis, MN, sCD40L: Bender MedSystems, Burlingame, CA) according to the manufacturer's instructions.


Gene_expression (measured) of P-Selectin associated with adhesions
17) Confidence 0.65 Published 2010 Journal Nutr J Section Body Doc Link PMC2841082 Disease Relevance 0.67 Pain Relevance 0
One week was allowed for progression of inflammation and recruitment of macrophages, as it has been shown that inflammatory events at the endothelial layer (e.g. expression of inflammatory cell adhesion molecules E-selectin and P-selectin) begin as early as one hour after induction of the injury[24].
Gene_expression (expression) of P-selectin in macrophages associated with inflammation, injury and adhesions
18) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952595 Disease Relevance 0.82 Pain Relevance 0.38
In the culprit lesions of UAP patients, 17 of the 23 lesions (74%) contained GP IIb/IIIa positive platelet thrombi, and all these platelet thrombi were positive for P-selectin.
Gene_expression (positive) of P-selectin in platelet associated with angina
19) Confidence 0.65 Published 2005 Journal Int. J. Mol. Med. Section Abstract Doc Link 15754016 Disease Relevance 1.12 Pain Relevance 0.98
Platelet P-selectin expression was determined by flow cytometry and cell-free COX enzyme activity was quantified by luminol-enhanced luminescence of human platelet microsomes.
Gene_expression (expression) of P-selectin in platelet
20) Confidence 0.62 Published 2008 Journal J. Thromb. Haemost. Section Body Doc Link 17944992 Disease Relevance 0 Pain Relevance 0

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