INT49146

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Context Info
Confidence 0.57
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.46
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Hgf) extracellular space (Hgf) cell morphogenesis (Hgf)
Anatomy Link Frequency
HGF 2
sensory neurons 1
hepatocytes 1
paw 1
spinal cord 1
Hgf (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 7 100.00 Very High Very High Very High
Inflammation 7 99.62 Very High Very High Very High
Antinociceptive 8 99.46 Very High Very High Very High
Spinal cord 2 99.00 Very High Very High Very High
qutenza 2 97.22 Very High Very High Very High
intrathecal 6 97.16 Very High Very High Very High
cINOD 8 89.96 High High
substance P 1 89.76 High High
isoflurane 3 88.96 High High
Neuropeptide 4 86.00 High High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 2 99.82 Very High Very High Very High
Pathologic Neovascularization 2 99.64 Very High Very High Very High
Pneumonia 4 99.62 Very High Very High Very High
Cancer 49 96.96 Very High Very High Very High
Pancreatic Cancer 57 96.56 Very High Very High Very High
Metastasis 7 96.36 Very High Very High Very High
Carcinoma 1 94.00 High High
Heart Rate Under Development 1 91.12 High High
INFLAMMATION 2 87.32 High High
Targeted Disruption 16 85.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ablation of sensory neurons (by capsaicin) markedly decreased the PAR2-mediated airway constriction, and virtually abolished PAR2-mediated pulmonary inflammation and edema, as did blockade of NK1 or NK2 receptors.
Negative_regulation (blockade) of NK2 in sensory neurons associated with pressure and volume under development, inflammation, qutenza and pneumonia
1) Confidence 0.57 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16081834 Disease Relevance 0.55 Pain Relevance 0.40
Sendide is a selective and extremely potent antagonist of neurokinin-1 (NK1) receptors in the mouse spinal cord.
Negative_regulation (antagonist) of NK1 in spinal cord associated with antagonist and spinal cord
2) Confidence 0.42 Published 1995 Journal Pain Section Abstract Doc Link 7540280 Disease Relevance 0.05 Pain Relevance 0.46
The antinociceptive activities of sendide, an antagonist of NK1 receptors, and its analogue, [D-Trp7]sendide have been examined after intrathecal (i.t.) administrations in the mouse paw formalin test.
Negative_regulation (antagonist) of NK1 in paw associated with antagonist, antinociceptive and intrathecal
3) Confidence 0.42 Published 1995 Journal Pain Section Abstract Doc Link 7540280 Disease Relevance 0.06 Pain Relevance 0.49
Hepatocyte growth factor/scatter factor (HGF/SF), a potent and independent angiogenic factor, has been implicated in tumorigenesis, but limited knowledge exists on the potential targets for inhibiting HGF/SF-induced pathological angiogenesis.
Negative_regulation (inhibiting) of HGF/SF in HGF associated with pathologic neovascularization
4) Confidence 0.41 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14678996 Disease Relevance 0.35 Pain Relevance 0.50
HGF mediated c-Met phosphorylation as well as downstream signaling via Erk1/2 and Akt were completely abolished in hepatocytes isolated from c-Metfl/fl;Mx1-Cre+/?
Negative_regulation (abolished) of HGF in hepatocytes
5) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.05 Pain Relevance 0.04
NK4 is a four-kringle fragment of HGF and acts as an HGF-antagonist and an angiogenesis inhibitor.
Negative_regulation (inhibitor) of HGF-antagonist in HGF associated with antagonist
6) Confidence 0.18 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 1.39 Pain Relevance 0.05

General Comments

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