INT49147

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Context Info
Confidence 0.76
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 27
Total Number 27
Disease Relevance 6.57
Pain Relevance 14.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Npy1r) plasma membrane (Npy1r) molecular_function (Npy1r)
signal transducer activity (Npy1r)
Anatomy Link Frequency
DRG 4
cortex 3
brain 2
neurons 2
dentate gyrus 1
Npy1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 85 100.00 Very High Very High Very High
Somatostatin 14 100.00 Very High Very High Very High
Pain 74 99.92 Very High Very High Very High
Anterior cingulate cortex 4 99.92 Very High Very High Very High
Locus ceruleus 7 99.68 Very High Very High Very High
c fibre 2 99.68 Very High Very High Very High
withdrawal 9 99.58 Very High Very High Very High
Sciatic nerve 8 99.56 Very High Very High Very High
addiction 2 99.26 Very High Very High Very High
Spinal cord 40 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 77 99.72 Very High Very High Very High
Pulpitis 5 98.80 Very High Very High Very High
INFLAMMATION 52 98.60 Very High Very High Very High
Depression 15 98.60 Very High Very High Very High
Ganglion Cysts 3 98.48 Very High Very High Very High
Neuropathic Pain 14 95.24 Very High Very High Very High
Injury 17 94.28 High High
Neuroma 3 87.84 High High
Convulsion 8 83.44 Quite High
Vibrio Infection 3 80.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As pulpitis progressed, there was a significant decrease in number of blood vessels expressing Y1R in the odontoblast layer when compared to control rat pulp.
Gene_expression (expressing) of Y1R in blood vessels
1) Confidence 0.76 Published 2010 Journal Int Endod J Section Body Doc Link 20536577 Disease Relevance 0.06 Pain Relevance 0
The hypothesis was that the expression of Y1R varies during different stages of pulpitis.
Gene_expression (expression) of Y1R associated with pulpitis
2) Confidence 0.76 Published 2010 Journal Int Endod J Section Abstract Doc Link 20536577 Disease Relevance 0.27 Pain Relevance 0.27
RT-PCR was performed to verify gene expression of Y1R in dental pulp and trigeminal ganglion.
Gene_expression (expression) of Y1R in trigeminal ganglion
3) Confidence 0.76 Published 2010 Journal Int Endod J Section Body Doc Link 20536577 Disease Relevance 0.08 Pain Relevance 0
In pulpitis, immune cells such as CD43+ granulocytes and CD4+ lymphocytes expressed Y1R.
Gene_expression (expressed) of Y1R in granulocytes
4) Confidence 0.76 Published 2010 Journal Int Endod J Section Body Doc Link 20536577 Disease Relevance 0.07 Pain Relevance 0
The neuropeptide tyrosine Y1R is expressed in interneurons and projection neurons in the dorsal horn and area X of the rat spinal cord.
Gene_expression (expressed) of neuropeptide tyrosine Y1R in interneurons associated with dorsal horn, neuropeptide, projection neuron and spinal cord
5) Confidence 0.75 Published 2006 Journal Neuroscience Section Title Doc Link 16448775 Disease Relevance 0 Pain Relevance 0.58
We have found that a number of genes altered at 28d were also altered in the hippocampus during LTP: brain-derived neurotrophic factor (BDNF), early growth response 1 (EGR1), CD9 antigen (CD9), neuropeptide Y receptor Y5 (NPY5R), and neuropeptide Y receptor (NPY1R) [41].
Gene_expression (antigen) of NPY1R in brain associated with neuropeptide, long-term potentiation and hippocampus
6) Confidence 0.58 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2315656 Disease Relevance 0.67 Pain Relevance 0.97
The lamina II neurons express somatostatin [The neuropeptide Y Y1 receptor is a somatic receptor on dorsal root ganglion neurons and a postsynaptic receptor on somatostatin dorsal horn neurons.
Gene_expression (express) of Y Y1 receptor in dorsal root ganglion associated with ganglion cysts, root ganglion neuron, neuropeptide, somatostatin and dorsal horn neuron
7) Confidence 0.56 Published 2006 Journal Neuroscience Section Abstract Doc Link 16448775 Disease Relevance 0.18 Pain Relevance 0.66
In situ hybridization histochemistry was used to measure mRNA expression levels of NPY and NPY receptors, Y1 and Y2, in the FSL as compared to the control Flinder resistant Line rats (FRL).
Gene_expression (expression) of Y1
8) Confidence 0.51 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9729278 Disease Relevance 0.32 Pain Relevance 0.52
Alterations in neuropeptide Y and Y1 receptor mRNA expression in brains from an animal model of depression: region specific adaptation after fluoxetine treatment.
Gene_expression (expression) of Y1 in brains associated with depression, neuropeptide and fluoxetine
9) Confidence 0.51 Published 1998 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9729278 Disease Relevance 0.39 Pain Relevance 0.59
Y1 receptor mRNA expression was decreased in different cortical regions (retrosplenial, anterior cingulate, and occipital) and in the hippocampal dentate gyrus.
Gene_expression (expression) of Y1 in dentate gyrus associated with anterior cingulate
10) Confidence 0.51 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9729278 Disease Relevance 0.38 Pain Relevance 0.67
Effect of a graded single constriction of the rat sciatic nerve on pain behavior and expression of immunoreactive NPY and NPY Y1 receptor in DRG neurons and spinal cord.
Gene_expression (expression) of Y1 receptor in neurons associated with pain, sciatic nerve and spinal cord
11) Confidence 0.51 Published 2004 Journal Brain Res. Section Title Doc Link 15047027 Disease Relevance 0.50 Pain Relevance 0.77
We also monitored changes in the expression of neuropeptide Y (NPY) and the NPY Y1 receptor (Y1R) in the lumbar 4-5 dorsal root ganglia (DRG) and dorsal horn and found upregulation of NPY and downregulation of the Y1R in DRG neurons after injury.
Gene_expression (expression) of Y1R in DRG associated with injury, dorsal horn and neuropeptide
12) Confidence 0.45 Published 2004 Journal Brain Res. Section Abstract Doc Link 15047027 Disease Relevance 0.46 Pain Relevance 0.50
We also monitored changes in the expression of neuropeptide Y (NPY) and the NPY Y1 receptor (Y1R) in the lumbar 4-5 dorsal root ganglia (DRG) and dorsal horn and found upregulation of NPY and downregulation of the Y1R in DRG neurons after injury.
Gene_expression (expression) of Y1 receptor in DRG associated with injury, dorsal horn and neuropeptide
13) Confidence 0.40 Published 2004 Journal Brain Res. Section Abstract Doc Link 15047027 Disease Relevance 0.46 Pain Relevance 0.50
Conversely, as expected, arcuate nucleus NPY mRNA expression was markedly upregulated by negative energy balance, but was unchanged by recent food consumption.
Gene_expression (expression) of NPY mRNA in arcuate nucleus
14) Confidence 0.36 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16931647 Disease Relevance 0 Pain Relevance 0.45
These results coincide with the previous findings with the elevated expression of SRIF and NPY mRNA in electrically and pharmacologically kindled models, suggesting the important role of these peptides in the kindling phenomenon.
Gene_expression (expression) of NPY mRNA
15) Confidence 0.28 Published 2000 Journal Brain Res. Section Abstract Doc Link 10678775 Disease Relevance 0.15 Pain Relevance 0.57
RT-PCR was performed to verify gene expression of Y1R in dental pulp and trigeminal ganglion.
Gene_expression (expression) of Y1R in dental pulp
16) Confidence 0.26 Published 2010 Journal Int Endod J Section Body Doc Link 20536577 Disease Relevance 0.08 Pain Relevance 0
The neuropeptide tyrosine Y1R is expressed in interneurons and projection neurons in the dorsal horn and area X of the rat spinal cord.
Gene_expression (expressed) of neuropeptide tyrosine Y1R in projection neurons associated with dorsal horn, neuropeptide, projection neuron and spinal cord
17) Confidence 0.25 Published 2006 Journal Neuroscience Section Title Doc Link 16448775 Disease Relevance 0 Pain Relevance 0.58
Previously, we observed specific alterations of neuropeptide Y (NPY) and Y1 receptor mRNA expression in discrete regions of the Flinders Sensitive Line rats (FSL), an animal model of depression.
Gene_expression (expression) of Y1 receptor mRNA associated with depression and neuropeptide
18) Confidence 0.23 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10327163 Disease Relevance 0.22 Pain Relevance 0.30
The eluted FC5 exhibited nearly a 2-fold increase in radioactivity counts when eluted with thebaine versus codeine, whereas FC45 exhibited an ?
Gene_expression (exhibited) of FC5 associated with codeine
19) Confidence 0.20 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1636496 Disease Relevance 0 Pain Relevance 1.02
Radiolabeled FC5 and FC45 RNA were prepared using the Ampliscribe T7 High Yield Transcription Kit with minor modifications to the manufacturer's instructions (3 mM each rATP, rCTP, rUTP, 150 ?
Gene_expression (prepared) of FC5
20) Confidence 0.20 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1636496 Disease Relevance 0 Pain Relevance 0.17

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