INT49169

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Context Info
Confidence 0.45
First Reported 1995
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 3
Total Number 6
Disease Relevance 4.67
Pain Relevance 2.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos1) mitochondrion (Nos1) oxidoreductase activity (Nos1)
plasma membrane (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
Anatomy Link Frequency
neuronal 4
spinal cord 2
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 8 100.00 Very High Very High Very High
neuralgia 2 100.00 Very High Very High Very High
anesthesia 3 99.28 Very High Very High Very High
Central grey 12 99.02 Very High Very High Very High
halothane 1 98.84 Very High Very High Very High
Spinal cord 4 98.80 Very High Very High Very High
Lasting pain 2 98.44 Very High Very High Very High
Glutamate 4 98.24 Very High Very High Very High
nMDA receptor 4 97.84 Very High Very High Very High
Neurotransmitter 1 96.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 28 100.00 Very High Very High Very High
Anxiety Disorder 5 99.42 Very High Very High Very High
Nociception 8 99.40 Very High Very High Very High
Urological Neuroanatomy 12 99.02 Very High Very High Very High
Pain 9 98.00 Very High Very High Very High
Cv Unclassified Under Development 50 95.72 Very High Very High Very High
Injury 38 94.56 High High
INFLAMMATION 2 93.40 High High
Hyperalgesia 2 92.88 High High
Necrosis 16 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of genetic knockout or pharmacologic inhibition of neuronal nitric oxide synthase on complete Freund's adjuvant-induced persistent pain.
Regulation (Effect) of Negative_regulation (inhibition) of neuronal nitric oxide synthase in neuronal associated with pain, targeted disruption, neuralgia, lasting pain and neuronal nitric oxide synthase
1) Confidence 0.45 Published 2005 Journal Pain Section Title Doc Link 16297560 Disease Relevance 1.16 Pain Relevance 1.05
It remains unclear however, whether the inhibition of nNOS within the mouse PAG changes the anxiety-like behavior per se or the effects of the inhibition of nNOS depend on the suppression of downstream of glutamate-NMDA receptor activation.
Spec (whether) Regulation (effects) of Negative_regulation (inhibition) of nNOS associated with glutamate, nmda receptor, anxiety disorder and central grey
2) Confidence 0.39 Published 2008 Journal Brain Res. Section Abstract Doc Link 18793618 Disease Relevance 0.98 Pain Relevance 0.73
Injection i.t. of 7-NI (30 min), a selective inhibitor of neuronal NOS (nNOS), inhibited NOS activity in the spinal cord and produced anti-nociception, confirming that writhing is sensitive to inhibition of nNOS.
Regulation (sensitive) of Negative_regulation (inhibition) of nNOS in spinal cord associated with nociception and spinal cord
3) Confidence 0.38 Published 2000 Journal Pain Section Abstract Doc Link 10779667 Disease Relevance 0.50 Pain Relevance 0.15
(iv) Study 4: To investigate the location of the action of exogenous NO and of nNOS inhibition in relation to mitoKATP channels and p38MAPK
Spec (investigate) Regulation (location) of Negative_regulation (inhibition) of nNOS
4) Confidence 0.37 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 0.54 Pain Relevance 0.15
(iv) The relationship of exogenous NO and nNOS inhibition with mitoKATP channels and p38MAPK
Regulation (relationship) of Negative_regulation (inhibition) of nNOS
5) Confidence 0.37 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 1.40 Pain Relevance 0.17
The effects of selective neuronal nitric oxide synthase inhibition on the anesthetic requirements in mice congenitally deficient in neuronal nitric oxide synthase (knockout mice) were examined.
Spec (examined) Regulation (effects) of Negative_regulation (inhibition) of neuronal nitric oxide synthase in neuronal associated with targeted disruption and neuronal nitric oxide synthase
6) Confidence 0.31 Published 1995 Journal Anesthesiology Section Abstract Doc Link 7541615 Disease Relevance 0.10 Pain Relevance 0.44

General Comments

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