INT49170

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2011
Negated 0
Speculated 2
Reported most in Abstract
Documents 116
Total Number 119
Disease Relevance 60.66
Pain Relevance 58.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos1) mitochondrion (Nos1) oxidoreductase activity (Nos1)
plasma membrane (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
Anatomy Link Frequency
neuronal 19
nerve 6
spinal 5
brain 3
hippocampus 3
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 699 100.00 Very High Very High Very High
Spinal cord 512 100.00 Very High Very High Very High
medulla 175 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 101 100.00 Very High Very High Very High
addiction 15 100.00 Very High Very High Very High
antagonist 111 99.98 Very High Very High Very High
Neuropathic pain 278 99.84 Very High Very High Very High
nMDA receptor antagonist 3 99.84 Very High Very High Very High
tail-flick 57 99.78 Very High Very High Very High
Antinociceptive 82 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 1046 100.00 Very High Very High Very High
Morphine Dependence 4 100.00 Very High Very High Very High
Hypothermia 55 99.98 Very High Very High Very High
Neuropathic Pain 548 99.84 Very High Very High Very High
Nervous System Injury 749 99.80 Very High Very High Very High
Urological Neuroanatomy 190 99.68 Very High Very High Very High
Injury 349 99.66 Very High Very High Very High
Hypoxia 26 99.64 Very High Very High Very High
Adhesions 20 99.58 Very High Very High Very High
Hyperalgesia 206 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of genetic knockout or pharmacologic inhibition of neuronal nitric oxide synthase on complete Freund's adjuvant-induced persistent pain.
Negative_regulation (inhibition) of neuronal nitric oxide synthase in neuronal associated with pain, targeted disruption, neuralgia, lasting pain and neuronal nitric oxide synthase
1) Confidence 0.59 Published 2005 Journal Pain Section Title Doc Link 16297560 Disease Relevance 1.16 Pain Relevance 1.05
Furthermore, intrathecal injection of either L-NAME or 7-nitroindazole, a selective nNOS inhibitor, markedly attenuated mechanical pain hypersensitivity at both 2 and 24h after CFA injection.
Negative_regulation (inhibitor) of nNOS associated with hypersensitivity, stimulus evoked pain and intrathecal
2) Confidence 0.59 Published 2005 Journal Pain Section Abstract Doc Link 16297560 Disease Relevance 1.79 Pain Relevance 1.24
The effects of 7-nitroindazole (7-NI), an inhibitor of the neuronal nitric oxide synthase (nNOS) which does not increase blood pressure, on tolerance to the antinociceptive activity of mu-(morphine), kappa-(U-50,488H) and delta-([D-Pen2, D-Pen5]enkephalin, DPDPE) opioid receptor agonists were determined in mice.
Negative_regulation (inhibitor) of nNOS in neuronal associated with agonist, tolerance, opioid receptor, enkephalin, antinociceptive, morphine and neuronal nitric oxide synthase
3) Confidence 0.59 Published 1997 Journal Peptides Section Abstract Doc Link 9285927 Disease Relevance 0 Pain Relevance 0.76
The effects of 7-nitroindazole (7-NI), an inhibitor of the neuronal nitric oxide synthase (nNOS) which does not increase blood pressure, on tolerance to the antinociceptive activity of mu-(morphine), kappa-(U-50,488H) and delta-([D-Pen2, D-Pen5]enkephalin, DPDPE) opioid receptor agonists were determined in mice.
Negative_regulation (inhibitor) of neuronal nitric oxide synthase in neuronal associated with agonist, tolerance, opioid receptor, enkephalin, antinociceptive, morphine and neuronal nitric oxide synthase
4) Confidence 0.59 Published 1997 Journal Peptides Section Abstract Doc Link 9285927 Disease Relevance 0 Pain Relevance 0.76
Study on the influence of potent inhibitors of neuronal nitric oxide synthase on the antinociceptive and anticonvulsant activity of benzodiazepines in mice.
Negative_regulation (inhibitors) of neuronal nitric oxide synthase in neuronal associated with analgesic, anticonvulsant, antinociceptive and neuronal nitric oxide synthase
5) Confidence 0.58 Published 2003 Journal Pol J Pharmacol Section Title Doc Link 12926546 Disease Relevance 0.21 Pain Relevance 0.53
Anxiogenic-like effects induced by NMDA receptor activation are prevented by inhibition of neuronal nitric oxide synthase in the periaqueductal gray in mice.
Negative_regulation (inhibition) of neuronal nitric oxide synthase in neuronal associated with nmda receptor, central grey and neuronal nitric oxide synthase
6) Confidence 0.57 Published 2008 Journal Brain Res. Section Title Doc Link 18793618 Disease Relevance 0.86 Pain Relevance 0.70
The encoded enzyme plays an important role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity.
Negative_regulation (inhibit) of nitric oxide synthase
7) Confidence 0.57 Published 2010 Journal Virol J Section Body Doc Link PMC2887434 Disease Relevance 0.82 Pain Relevance 0.03
It remains unclear however, whether the inhibition of nNOS within the mouse PAG changes the anxiety-like behavior per se or the effects of the inhibition of nNOS depend on the suppression of downstream of glutamate-NMDA receptor activation.
Negative_regulation (inhibition) of nNOS associated with glutamate, nmda receptor, anxiety disorder and central grey
8) Confidence 0.50 Published 2008 Journal Brain Res. Section Abstract Doc Link 18793618 Disease Relevance 0.95 Pain Relevance 0.73
It remains unclear however, whether the inhibition of nNOS within the mouse PAG changes the anxiety-like behavior per se or the effects of the inhibition of nNOS depend on the suppression of downstream of glutamate-NMDA receptor activation.
Negative_regulation (inhibition) of nNOS associated with glutamate, nmda receptor, anxiety disorder and central grey
9) Confidence 0.50 Published 2008 Journal Brain Res. Section Abstract Doc Link 18793618 Disease Relevance 0.98 Pain Relevance 0.73
l), a selective nNOS inhibitor, also dramatically attenuated nerve injury-induced mechanical hypersensitivity.
Negative_regulation (inhibitor) of nNOS in nerve associated with nervous system injury and hypersensitivity
10) Confidence 0.50 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2089056 Disease Relevance 1.64 Pain Relevance 0.57
g) or 1-(2-trifluoromethylphenyl) imidazole (a nNOS inhibitor, 30 ?
Negative_regulation (inhibitor) of nNOS
11) Confidence 0.50 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 0.91 Pain Relevance 0.51
When comparisons were made between 2-vs 12-months of age, results indicate that nNOS mRNA level was reduced (P < 0.01) in the hippocampus but increased (P < 0.01) in the cortex of SAMP8 and SAMR1.
Negative_regulation (reduced) of nNOS mRNA in cortex associated with hippocampus
12) Confidence 0.50 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1766358 Disease Relevance 0.27 Pain Relevance 0.36
From 2 to 8 months of age, a significant decrease (P < 0.01) in nNOS mRNA level was seen in the three brain areas of SAMP8 but only in the cortex and the hippocampus of SAMR1.
Negative_regulation (decrease) of nNOS mRNA in brain associated with hippocampus
13) Confidence 0.50 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1766358 Disease Relevance 0.40 Pain Relevance 0.27
By contrast, nNOS activity markedly decreased (P < 0.01) in the hippocampus at 8-vs 2 months of age and remained low with age.
Negative_regulation (decreased) of nNOS in hippocampus associated with hippocampus
14) Confidence 0.50 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1766358 Disease Relevance 0 Pain Relevance 0.39
Injection i.t. of 7-NI (30 min), a selective inhibitor of neuronal NOS (nNOS), inhibited NOS activity in the spinal cord and produced anti-nociception, confirming that writhing is sensitive to inhibition of nNOS.
Negative_regulation (inhibitor) of nNOS in spinal cord associated with nociception and spinal cord
15) Confidence 0.50 Published 2000 Journal Pain Section Abstract Doc Link 10779667 Disease Relevance 0.46 Pain Relevance 0.16
Injection i.t. of 7-NI (30 min), a selective inhibitor of neuronal NOS (nNOS), inhibited NOS activity in the spinal cord and produced anti-nociception, confirming that writhing is sensitive to inhibition of nNOS.
Negative_regulation (inhibition) of nNOS in spinal cord associated with nociception and spinal cord
16) Confidence 0.50 Published 2000 Journal Pain Section Abstract Doc Link 10779667 Disease Relevance 0.50 Pain Relevance 0.15
This novel effect appears to be initiated by the transient inhibition of nNOS as delayed anti-nociception was mimicked by 7-NI at doses (10-100 nmol) that no longer inhibited spinal nNOS (25 nmol) at 24 h.
Negative_regulation (inhibition) of nNOS in spinal associated with nociception
17) Confidence 0.50 Published 2000 Journal Pain Section Abstract Doc Link 10779667 Disease Relevance 0.47 Pain Relevance 0.08
(iv) The relationship of exogenous NO and nNOS inhibition with mitoKATP channels and p38MAPK
Negative_regulation (inhibition) of nNOS
18) Confidence 0.48 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 1.38 Pain Relevance 0.17
(iv) Study 4: To investigate the location of the action of exogenous NO and of nNOS inhibition in relation to mitoKATP channels and p38MAPK
Negative_regulation (inhibition) of nNOS
19) Confidence 0.48 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 0.52 Pain Relevance 0.15
This thesis gets support from the finding that the specific inhibition of nNOS was more protective than the non-specific inhibition of NOS.
Negative_regulation (inhibition) of nNOS
20) Confidence 0.48 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 0.22 Pain Relevance 0.03

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