INT49171

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Context Info
Confidence 0.78
First Reported 1995
Last Reported 2011
Negated 12
Speculated 9
Reported most in Abstract
Documents 241
Total Number 250
Disease Relevance 140.70
Pain Relevance 104.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos1) mitochondrion (Nos1) oxidoreductase activity (Nos1)
plasma membrane (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
Anatomy Link Frequency
neuronal 34
spinal cord 28
sciatic nerve 16
brain 10
muscles 8
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 3024 100.00 Very High Very High Very High
Spinal cord 2607 100.00 Very High Very High Very High
opioid receptor 868 100.00 Very High Very High Very High
Neurotransmitter 182 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 137 100.00 Very High Very High Very High
cocaine 60 100.00 Very High Very High Very High
Calcitonin gene-related peptide 39 100.00 Very High Very High Very High
substance P 31 100.00 Very High Very High Very High
Enkephalin 28 100.00 Very High Very High Very High
Neuropeptide 13 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 5144 100.00 Very High Very High Very High
Disease 675 100.00 Very High Very High Very High
Nociception 547 100.00 Very High Very High Very High
Nervous System Injury 2551 99.92 Very High Very High Very High
Amyloid Plaque 28 99.90 Very High Very High Very High
INFLAMMATION 826 99.84 Very High Very High Very High
Apoptosis 370 99.82 Very High Very High Very High
Neuropathic Pain 2631 99.76 Very High Very High Very High
Ganglion Cysts 802 99.68 Very High Very High Very High
Herpes Simplex Virus Infection 26 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The MOR(-/-) mice showed a significantly higher morphine-induced nNOS expression level (+103%) or a lower cocaine-induced nNOS expression level (+38%) in the DG than in the morphine- or cocaine-treated MOR(+/+) mice.
Gene_expression (expression) of nNOS associated with hippocampus, cocaine and morphine
1) Confidence 0.78 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300892 Disease Relevance 0.08 Pain Relevance 1.71
The MOR(-/-) mice showed a significantly higher morphine-induced nNOS expression level (+103%) or a lower cocaine-induced nNOS expression level (+38%) in the DG than in the morphine- or cocaine-treated MOR(+/+) mice.
Gene_expression (expression) of nNOS associated with hippocampus, cocaine and morphine
2) Confidence 0.78 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300892 Disease Relevance 0.08 Pain Relevance 1.70
OBJECTIVE: The present study was undertaken to determine the effect of chronic morphine treatment and abstinence on the expression of neuronal NO synthase (neuronal NOS, nNOS) in several brain regions of mice.
Gene_expression (expression) of neuronal NO synthase in brain
3) Confidence 0.78 Published 2000 Journal Psychopharmacology (Berl.) Section Body Doc Link 10663419 Disease Relevance 0.09 Pain Relevance 0
Here, we show that 5-HT(1A)R-selective agonist 8-OH-DPAT and selective serotonin reuptake inhibitor (SSRI) fluoxetine downregulated hippocampal neuronal nitric oxide synthase (nNOS) expression, whereas 5-HT(1A)R-selective antagonist NAN-190 upregulated hippocampal nNOS expression.
Gene_expression (expression) of nNOS in neuronal associated with antagonist, agonist, ssri, neuronal nitric oxide synthase and fluoxetine
4) Confidence 0.77 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20164327 Disease Relevance 0.61 Pain Relevance 0.44
Because nNOS is constitutively expressed in eNOS mutants, these findings coupled with the TTX results suggest that an nNOS-dependent mechanism may compensate for the chronic loss of eNOS activity after targeted gene disruption.
Gene_expression (expressed) of nNOS associated with tetrodotoxin
5) Confidence 0.77 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8853353 Disease Relevance 0.14 Pain Relevance 0.44
There were no substantial alternations in the expression level of NOS1 at the herpetic and postherpetic stages.
Gene_expression (expression) of NOS1 associated with herpes simplex virus infection
6) Confidence 0.77 Published 2007 Journal Neuroscience Section Abstract Doc Link 17997045 Disease Relevance 1.33 Pain Relevance 0.78
We investigated whether the changes in acetylcholine receptor (AChR) distribution and neuronal nitric oxide synthase (nNOS) expression reported for the skeletal muscle of mdx mice were a consequence of muscle fiber regeneration rather than of the absence of dystrophin.
Gene_expression (expression) of nNOS in muscle fiber associated with neuronal nitric oxide synthase
7) Confidence 0.76 Published 2001 Journal Muscle Nerve Section Abstract Doc Link 11353428 Disease Relevance 0 Pain Relevance 0.17
We investigated whether the changes in acetylcholine receptor (AChR) distribution and neuronal nitric oxide synthase (nNOS) expression reported for the skeletal muscle of mdx mice were a consequence of muscle fiber regeneration rather than of the absence of dystrophin.
Gene_expression (expression) of neuronal nitric oxide synthase in muscle fiber associated with neuronal nitric oxide synthase
8) Confidence 0.76 Published 2001 Journal Muscle Nerve Section Abstract Doc Link 11353428 Disease Relevance 0 Pain Relevance 0.17
Our results revealed that the mRNA expression of inducible nitric oxide synthase (iNOS) was reduced by approximately 50% in GEB-pretreated mice versus the controls, whereas the mRNA expression levels of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) remained unchanged.
Gene_expression (expression) of nNOS in neuronal associated with neuronal nitric oxide synthase
9) Confidence 0.76 Published 2007 Journal Int. J. Mol. Med. Section Abstract Doc Link 17611639 Disease Relevance 0.46 Pain Relevance 0.14
Finally, we examined whether peripheral spinal nerve injury altered the expression of nNOS, iNOS, or eNOS in the DRG and spinal cord of WT mice.
Gene_expression (expression) of nNOS in spinal nerve associated with dorsal root ganglion, nervous system injury and spinal cord
10) Confidence 0.76 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.20 Pain Relevance 0.56
Consistent with these findings in rats, our study showed that unilateral injury of the fifth spinal nerve in mice also increased expression of nNOS protein in the ipsilateral fifth DRG, but not in dorsal horn.
Gene_expression (expression) of nNOS protein in dorsal horn associated with dorsal root ganglion, injury and dorsal horn
11) Confidence 0.76 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.19 Pain Relevance 0.90
Immunohistochemistry demonstrated a consistent reduction of nNOS and NK2 receptor expression in mdx stomach smooth muscle cells and no change in nNOS and NK1 receptor expression in neurones.
Gene_expression (expression) of nNOS in stomach smooth muscle
12) Confidence 0.76 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16918764 Disease Relevance 0 Pain Relevance 0.32
Endoluminal pressure was recorded and the expression of neuronal nitric oxide synthase (nNOS), NK1 and NK2 neurokinin receptors was investigated by immunohistochemistry.
Spec (investigated) Gene_expression (expression) of neuronal nitric oxide synthase in neuronal associated with neuronal nitric oxide synthase
13) Confidence 0.76 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16918764 Disease Relevance 0 Pain Relevance 0.30
Endoluminal pressure was recorded and the expression of neuronal nitric oxide synthase (nNOS), NK1 and NK2 neurokinin receptors was investigated by immunohistochemistry.
Spec (investigated) Gene_expression (expression) of nNOS in neuronal associated with neuronal nitric oxide synthase
14) Confidence 0.76 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16918764 Disease Relevance 0 Pain Relevance 0.30
In addition, no compensatory changes in the spinal cord expression of NOS1 gene in sham-operated NOS2-KO mice have been also established.
Gene_expression (expression) of NOS1 gene in spinal cord associated with targeted disruption and spinal cord
15) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.21 Pain Relevance 0.86
Moreover, the presence of NOS2 is required to increase the spinal cord expression of NOS1 whereas an increased NOS1 expression might avoid the up-regulation of NOS2 in the spinal cord of nerve injured WT mice.


Gene_expression (expression) of NOS1 in nerve associated with spinal cord
16) Confidence 0.74 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001461 Disease Relevance 1.64 Pain Relevance 1.01
In addition, our data also indicate that the presence of NOS2 is required for the increased expression of NOS1 in the spinal cord whereas an enhanced expression of NOS1 might avoid an up-regulation of NOS2 in the spinal cord of sciatic nerve-injured mice.
Gene_expression (expression) of NOS1 in sciatic nerve associated with sciatic nerve and spinal cord
17) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.36 Pain Relevance 0.95
Moreover, the presence of NOS2 is required to increase the spinal cord expression of NOS1 whereas an increased NOS1 expression might avoid the up-regulation of NOS2 in the spinal cord of nerve injured WT mice.


Gene_expression (expression) of NOS1 in nerve associated with spinal cord
18) Confidence 0.74 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001461 Disease Relevance 1.61 Pain Relevance 0.99
Sciatic nerve injury also increases the spinal cord expression of NOS1 and NOS2 isoforms, but not of NOS3, in WT and NOS1-KO mice respectively.
Gene_expression (expression) of NOS1 in NOS1 associated with targeted disruption, nervous system injury, sciatic nerve and spinal cord
19) Confidence 0.74 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001461 Disease Relevance 1.77 Pain Relevance 1.06
Several works have demonstrated that nerve injury after sciatic nerve ligation evoked an increased NOS1 and NOS2, but not of NOS3, protein expression in the ipsilateral site of the dorsal root ganglia and the sciatic nerve [4], [6]–[11].
Gene_expression (expression) of NOS1 in sciatic nerve associated with nervous system injury and sciatic nerve
20) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.49 Pain Relevance 1.17

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