INT49183

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Context Info
Confidence 0.49
First Reported 1993
Last Reported 2000
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.66
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TAC1) extracellular region (TAC1) plasma membrane (TAC1)
cell-cell signaling (TAC1)
Anatomy Link Frequency
neurons 2
sensory nerves 1
parasympathetic 1
TAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 8 99.98 Very High Very High Very High
Inflammatory mediators 1 99.62 Very High Very High Very High
narcan 11 99.20 Very High Very High Very High
substance P 18 96.82 Very High Very High Very High
antagonist 9 92.72 High High
agonist 5 80.12 Quite High
MU agonist 2 75.00 Quite High
Inflammation 1 66.64 Quite High
Hyperalgesia 1 64.08 Quite High
opioid receptor 1 59.84 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 2 99.42 Very High Very High Very High
Bronchospasm 5 86.92 High High
Increased Venous Pressure Under Development 1 84.48 Quite High
Abnormal Reflex 1 65.52 Quite High
Hyperalgesia 1 64.08 Quite High
Disease 1 39.60 Quite Low
Functional Bowel Disorder 1 38.24 Quite Low
Asthma 1 36.16 Quite Low
Overactive Bladder 2 34.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tachykinins mediate a variety of physiological processes in the gastrointestinal, pulmonary and genito-urinary tract mainly through the stimulation of NK1 and NK2 receptors.
Positive_regulation (mediate) of Positive_regulation (stimulation) of NK2
1) Confidence 0.49 Published 2000 Journal Neuropeptides Section Abstract Doc Link 11049734 Disease Relevance 0.28 Pain Relevance 0.14
This study demonstrates that exogenous SP, as well as endogenous tachykinins released from capsaicin-sensitive neurons, can liberate histamine, most likely from airway mast cells, by a mechanism that depends predominantly on the activation of NK1 and NK2 receptors.
Positive_regulation (depends) of Positive_regulation (activation) of NK2 in neurons associated with qutenza and substance p
2) Confidence 0.15 Published 1995 Journal J. Appl. Physiol. Section Abstract Doc Link 7542231 Disease Relevance 0 Pain Relevance 0.62
Capsaicin increases airflow resistance in guinea pigs in vivo by activating both NK2 and NK1 tachykinin receptors.
Positive_regulation (increases) of Positive_regulation (activating) of NK2 associated with qutenza
3) Confidence 0.13 Published 1993 Journal Am. Rev. Respir. Dis. Section Title Doc Link 7692775 Disease Relevance 0 Pain Relevance 0.52
Naloxone 10(-7) M significantly reversed medium stimulation of NK activity, induced by 25 U/ml, in a group as a whole.
Positive_regulation (induced) of Positive_regulation (stimulation) of NK associated with narcan
4) Confidence 0.07 Published 1993 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 7688780 Disease Relevance 0 Pain Relevance 0.64
It is proposed that substances that release tachykinins from airway sensory nerves, e.g. inflammatory mediators or irritants, may induce hyperresponsiveness of cholinergic bronchomotor responses by activation of NK2-receptors on parasympathetic airway nerves.
Spec (may) Positive_regulation (induce) of in sensory nerves Positive_regulation (activation) of NK2 in parasympathetic associated with inflammatory mediators
5) Confidence 0.06 Published 1996 Journal J Auton Pharmacol Section Abstract Doc Link 8736430 Disease Relevance 0.38 Pain Relevance 0.22

General Comments

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