INT49191

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Context Info
Confidence 0.41
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 9.96
Pain Relevance 3.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (IFNAR1)
Anatomy Link Frequency
kidney 2
muscle tissue 2
macrophages 1
embryo 1
plasmacytoid dendritic cell 1
IFNAR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 98 100.00 Very High Very High Very High
spinal-cord stimulation 10 99.86 Very High Very High Very High
chemokine 45 99.84 Very High Very High Very High
Inflammatory mediators 6 99.60 Very High Very High Very High
antagonist 8 98.56 Very High Very High Very High
Quantitative sensory testing 14 97.58 Very High Very High Very High
rheumatoid arthritis 58 96.20 Very High Very High Very High
Pain 94 94.88 High High
agonist 4 93.24 High High
c fibre 11 90.96 High High
Disease Link Frequency Relevance Heat
Complex Regional Pain Syndromes 182 100.00 Very High Very High Very High
Reflex Sympathetic Dystrophy 134 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 49 100.00 Very High Very High Very High
Amputation 9 99.60 Very High Very High Very High
INFLAMMATION 65 99.40 Very High Very High Very High
Frailty 10 99.04 Very High Very High Very High
Autoimmune Disease 4 98.94 Very High Very High Very High
Urological Neuroanatomy 1 98.80 Very High Very High Very High
Disease 68 97.72 Very High Very High Very High
Psoriasis 25 97.22 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Histological changes in muscle tissue may be present in the chronic phase of CRPS-I.
Gene_expression (present) of CRPS-I in muscle tissue associated with complex regional pain syndromes
1) Confidence 0.41 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18976942 Disease Relevance 1.01 Pain Relevance 0.09
In all patients histological analysis showed extensive changes in muscle tissue, such as fatty degeneration, fibre atrophy and nuclear clumping, which was not related to duration of CRPS-I prior to amputation.
Gene_expression (duration) of CRPS-I in muscle tissue associated with complex regional pain syndromes, frailty and amputation
2) Confidence 0.35 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18976942 Disease Relevance 1.42 Pain Relevance 0.07
Molecular modeling of the results of site-directed mutagenesis experiments performed in CHO cells stably transfected with the human AVP receptor subtypes revealed that non-peptide antagonists establish key contacts with a few amino acid residues of the receptor subtypes that are different from those involved in agonist binding.
Gene_expression (transfected) of AVP receptor associated with antagonist and agonist
3) Confidence 0.28 Published 2002 Journal Prog. Brain Res. Section Abstract Doc Link 12436935 Disease Relevance 0 Pain Relevance 0.16
There is no scientific evidence for SCS being effective in non-chronic CRPS-I.
Gene_expression (effective) of CRPS-I associated with complex regional pain syndromes and spinal-cord stimulation
4) Confidence 0.25 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2861029 Disease Relevance 1.16 Pain Relevance 0.83
Fatal outcome in experimentally infected mice and non human primates is associated with impairment of innate immune responses, including rapid and important secretion of certain inflammatory mediators and the absence of type I interferon (IFN) production, and also with profound suppression of adaptive immune responses, including impaired humoral responses and B and T lymphocyte apoptosis [30]–[35].
Gene_expression (production) of type I in T lymphocyte associated with inflammatory mediators and apoptosis
5) Confidence 0.13 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2950153 Disease Relevance 0.96 Pain Relevance 0.16
Indeed, macrophages challenged with EBOV and MARV in vitro release large quantities of several proinflammatory cytokines and chemokines, while production of type I IFNs is inhibited.
Gene_expression (production) of type I in macrophages associated with chemokine and cytokine
6) Confidence 0.11 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2950153 Disease Relevance 0.26 Pain Relevance 0.28
Similarly, fatal outcome in experimentally infected mice and non human primates is associated with impairment of innate immune responses, including rapid and important secretion of inflammatory mediators, contrasting with the absence of type I interferon production [30]–[35].
Gene_expression (production) of type I associated with inflammatory mediators
7) Confidence 0.11 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2950153 Disease Relevance 0.16 Pain Relevance 0.18
In the 1960s, CHIKV was used to stimulate type I interferon (IFN) production from chick embryo–like fibroblasts [20,21], and IFN most likely plays a prominent role in viral clearance and disease pathogenesis.
Gene_expression (production) of type I interferon in embryo associated with disease
8) Confidence 0.06 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1904475 Disease Relevance 0.38 Pain Relevance 0
RESULTS: CRPS-I was present in eight children in seven families, each of which also had additional functional/dysautonomic conditions, the most common (> or = 4 cases per condition) being gastrointestinal dysmotility, migraine, cyclic vomiting and chronic fatigue.
Gene_expression (present) of CRPS-I
9) Confidence 0.05 Published 2008 Journal Arch. Dis. Child. Section Body Doc Link 18192313 Disease Relevance 0.09 Pain Relevance 0
All QST changes were, to a lesser degree, also present in the contralateral limb, indicating that pathophysiological changes in CRPS I might also be subclinically present in the extremity which is not primarily affected by the disease.



Gene_expression (present) of CRPS I in limb associated with quantitative sensory testing, reflex sympathetic dystrophy and disease
10) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2453233 Disease Relevance 0.74 Pain Relevance 0.50
The expression in kidney tissue of interferon type I (IFNalpha) and type II (IFNgamma) genes and two of their inducible genes, Mx and gammaIP were monitored, using qRT-PCR, in a population of Atlantic salmon prior to and over the period of smolting and sea water transfer.
Gene_expression (expression) of interferon type I in kidney
11) Confidence 0.03 Published 2007 Journal Fish Shellfish Immunol. Section Abstract Doc Link 17467293 Disease Relevance 0 Pain Relevance 0
Expression of interferon type I and II, Mx and gammaIP genes in the kidney of Atlantic salmon, Salmo salar, is induced during smolting.
Gene_expression (Expression) of interferon type I in kidney associated with cytokine
12) Confidence 0.03 Published 2007 Journal Fish Shellfish Immunol. Section Title Doc Link 17467293 Disease Relevance 0 Pain Relevance 0.05
is a well-documented contributor to the psoriatic skin lesion, another important pathway for triggering common human autoimmune disease involves plasmacytoid dendritic cell precursors and type 1 interferon (INF) production.
Gene_expression (production) of type 1 interferon in plasmacytoid dendritic cell associated with psoriasis and autoimmune disease
13) Confidence 0.02 Published 2008 Journal The Open Rheumatology Journal Section Body Doc Link PMC2588090 Disease Relevance 1.73 Pain Relevance 0.98
Distribution of human i-NANC bronchodilator and nitric oxide-immunoreactive nerves.
Gene_expression (Distribution) of i-NANC in nerves
14) Confidence 0.02 Published 1995 Journal Am. J. Respir. Cell Mol. Biol. Section Title Doc Link 7542897 Disease Relevance 0 Pain Relevance 0.06
Studies in human postmortem brain have previously demonstrated a general decrease in calcium/cAMP-related signaling transcripts in frontal and motor cortex of human alcoholics [13], a decrease in adenylate cyclase (AC) type I (AC-I) protein levels and activity in temporal and frontal cortex in alcoholics [22]–[23] and in AC-I mRNA and protein in temporal cortex from heroin addicts [24].
Gene_expression (levels) of ) type I in frontal cortex associated with urological neuroanatomy
15) Confidence 0.02 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.52 Pain Relevance 0.18
In addition, ERA patients exhibited a mild dyslipidemia characterized by an increase in the serum levels of total cholesterol, LDL-cholesterol, triglycerides and Apo B as well as by a decrease in the serum levels of HDL-cholesterol and Apo A-I compared with controls.
Gene_expression (levels) of A-I associated with rheumatoid arthritis and disorder of lipid metabolism
16) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860077 Disease Relevance 1.42 Pain Relevance 0.30

General Comments

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