INT49196

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Context Info
Confidence 0.78
First Reported 1995
Last Reported 2010
Negated 4
Speculated 6
Reported most in Abstract
Documents 105
Total Number 111
Disease Relevance 107.29
Pain Relevance 22.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SELE) cell adhesion (SELE) plasma membrane (SELE)
Anatomy Link Frequency
endothelial cells 21
keratinocytes 3
leukocyte 3
endothelium 3
macrophages 2
SELE (Homo sapiens)
SELE - S128R (1)
Pain Link Frequency Relevance Heat
Inflammation 1394 100.00 Very High Very High Very High
cytokine 481 100.00 Very High Very High Very High
fibrosis 19 99.92 Very High Very High Very High
Arthritis 819 99.64 Very High Very High Very High
rheumatoid arthritis 1207 99.62 Very High Very High Very High
diclofenac 14 99.54 Very High Very High Very High
dexamethasone 38 99.52 Very High Very High Very High
methotrexate 101 99.24 Very High Very High Very High
Inflammatory response 170 99.18 Very High Very High Very High
Nicotine 100 98.94 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 1987 100.00 Very High Very High Very High
INFLAMMATION 1588 100.00 Very High Very High Very High
Fibrosis 9 99.92 Very High Very High Very High
Pre-eclampsia 506 99.82 Very High Very High Very High
Sepsis 661 99.64 Very High Very High Very High
Seronegative Spondarthritis 655 99.64 Very High Very High Very High
Rheumatoid Arthritis 1221 99.62 Very High Very High Very High
Cholesteatoma 48 99.52 Very High Very High Very High
Neuropathy 81 99.22 Very High Very High Very High
Increased Venous Pressure Under Development 450 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data suggest that E-selectin expression on the vascular endothelium of human skeletal muscle may represent a key regulatory point in the process of neutrophil tissue accumulation and indicate an active role for the venular endothelium in the development of human ischemia-reperfusion syndrome.
Gene_expression (expression) of E-selectin in neutrophil associated with syndrome and ischemia
1) Confidence 0.78 Published 1995 Journal Ultrastruct Pathol Section Abstract Doc Link 7543227 Disease Relevance 0.49 Pain Relevance 0.19
Expression of E-selectin in ischemic and reperfused human skeletal muscle.
Gene_expression (Expression) of E-selectin in skeletal muscle
2) Confidence 0.78 Published 1995 Journal Ultrastruct Pathol Section Title Doc Link 7543227 Disease Relevance 0.39 Pain Relevance 0.20
The expression of E-selectin is induced in human endothelium in response to cytokines such as interleukin-1 and tumor necrosis factor-?
Gene_expression (expression) of E-selectin in endothelium associated with necrosis, cancer and cytokine
3) Confidence 0.73 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 0.95 Pain Relevance 0.09
In the present study, we compared the levels of soluble VCAM-1 (sVCAM-1, CD106), ICAM-1 (sICAM-1, CD54) and E-selectin (sE-selectin, CD62E) in the maternal serum of normal and preeclamptic pregnancies.


Gene_expression (levels) of E-selectin
4) Confidence 0.73 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 1.17 Pain Relevance 0.03
Leptin, and vascular adhesion markers (soluble-Intercellular Adhesion Molecule-1, soluble-Vascular Cell Adhesion Molecule-1, soluble P-Selectin, soluble E-Selectin), and soluble CD40 ligand were measured using a commercially available enzyme-linked immunosorbent assay (ELISA) kits (leptin, adhesion markers: R&D Systems, Minneapolis, MN, sCD40L: Bender MedSystems, Burlingame, CA) according to the manufacturer's instructions.


Gene_expression (measured) of E-Selectin associated with adhesions
5) Confidence 0.65 Published 2010 Journal Nutr J Section Body Doc Link PMC2841082 Disease Relevance 0.67 Pain Relevance 0
These data demonstrate that diclofenac is capable of inhibiting the expression of E-selectin, ICAM-1 and VCAM-1 in HUVEC.
Gene_expression (expression) of E-selectin associated with diclofenac
6) Confidence 0.65 Published 1996 Journal Life Sci. Section Abstract Doc Link 8691982 Disease Relevance 0.30 Pain Relevance 0.36
Pretreatment of diclofenac inhibited LPS-induced expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in HUVEC, determined by flow cytometry and a cellular enzyme-linked immunosorbent assay (cell-ELISA).
Spec (determined) Gene_expression (expression) of E-selectin associated with diclofenac and adhesions
7) Confidence 0.65 Published 1996 Journal Life Sci. Section Abstract Doc Link 8691982 Disease Relevance 0.36 Pain Relevance 0.37
In the present study, we compared the levels of soluble VCAM-1 (sVCAM-1, CD106), ICAM-1 (sICAM-1, CD54) and E-selectin (sE-selectin, CD62E) in the maternal serum of normal and preeclamptic pregnancies.


Gene_expression (levels) of sE-selectin
8) Confidence 0.64 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 1.18 Pain Relevance 0.03
Moreover, during 24 hours incubation we have investigated the production of endothelin 1 (ET-1), E-selectin and Interleukin 8 (IL-8) and it appears that ozonation enhances IL-8, inhibits E-selectin and hardly modifies ET-1 production.
Spec (investigated) Gene_expression (production) of E-selectin
9) Confidence 0.63 Published 2000 Journal Mediators Inflamm Section Abstract Doc Link PMC1781775 Disease Relevance 0.23 Pain Relevance 0.18
Boldt and colleagues were able to show higher levels of sELAM-1 and sICAM-1 in patients older than 70 years in comparison with patients younger than 50 years, indicating an association with more extensive endothelial damage [43].
Gene_expression (levels) of sELAM-1
10) Confidence 0.61 Published 2005 Journal Crit Care Section Body Doc Link PMC1269435 Disease Relevance 0.90 Pain Relevance 0.14
We investigated the circulating levels of E-selectin, studied as a marker of endothelial dysfunction, in acute myocardial infarction.
Spec (investigated) Gene_expression (levels) of E-selectin associated with myocardial infarction
11) Confidence 0.60 Published 1995 Journal Int J Microcirc Clin Exp Section Abstract Doc Link 8655256 Disease Relevance 0.87 Pain Relevance 0.20
Here, we communicate that Dex at low concentrations (1-100 nM) markedly attenuates E-selectin expression without affecting NF-kappaB.
Gene_expression (expression) of E-selectin associated with dexamethasone
12) Confidence 0.59 Published 2007 Journal FASEB J. Section Abstract Doc Link 17099067 Disease Relevance 0.48 Pain Relevance 0.52
In endothelial MKP-1(-/-) cells differentiated from MKP-1(-/-) embryonic stem cells and in MKP-1-silenced human endothelial cells, Dex did not inhibit TNF-alpha-evoked E-selectin expression.
Gene_expression (expression) of E-selectin in embryonic stem cells associated with dexamethasone
13) Confidence 0.59 Published 2007 Journal FASEB J. Section Abstract Doc Link 17099067 Disease Relevance 0.44 Pain Relevance 0.50
Importantly, Dex is able to increase the expression of MKP-1, which causes an inactivation of TNF-alpha-induced p38 MAPK and mediates inhibition of E-selectin expression.
Gene_expression (expression) of E-selectin associated with dexamethasone
14) Confidence 0.59 Published 2007 Journal FASEB J. Section Abstract Doc Link 17099067 Disease Relevance 0.46 Pain Relevance 0.51
Dex is known to reduce the expression of E-selectin, which is largely regulated by NF-kappaB.
Gene_expression (expression) of E-selectin associated with dexamethasone
15) Confidence 0.59 Published 2007 Journal FASEB J. Section Abstract Doc Link 17099067 Disease Relevance 0.49 Pain Relevance 0.50
This investigation sought to determine whether systemic radionuclide therapy decreases the production of cell adhesion molecules (E-selectins) that participate in the metastatic process.
Gene_expression (production) of E-selectin associated with adhesions
16) Confidence 0.58 Published 2000 Journal J. Nucl. Med. Section Abstract Doc Link 10855628 Disease Relevance 0.43 Pain Relevance 0.25
To begin with, as mentioned above, an elevation in E-selectin levels appears to be a feature of certain groups of patients with CAD, restenosis as well as DM2.
Gene_expression (levels) of E-selectin associated with coronary artery disease, diabetes mellitus and cardiovascular disease
17) Confidence 0.57 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1933415 Disease Relevance 1.52 Pain Relevance 0
One study involving first degree relatives has indicated that soluble E-selectin levels are elevated in patients with DM2 carrying the 128R allele in comparison with their non-diabetic relatives [10].
Gene_expression (levels) of E-selectin associated with diabetes mellitus
18) Confidence 0.57 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1933415 Disease Relevance 1.59 Pain Relevance 0.09
Besides, it is still unclear whether the elevation in soluble E-selectin levels in such patients is directly linked to the S128R mutation or not.
Gene_expression (levels) of E-selectin
19) Confidence 0.57 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1933415 Disease Relevance 1.53 Pain Relevance 0.04
Lyall et al. (12) reported that serum levels of VCAM-1 and E-selectin were not significantly different between normal and preeclamptic pregnancies.
Gene_expression (levels) of E-selectin
20) Confidence 0.57 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 0.98 Pain Relevance 0.06

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