INT49203

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Context Info
Confidence 0.38
First Reported 1995
Last Reported 1995
Negated 3
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 1.33
Pain Relevance 3.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck)
Anatomy Link Frequency
nucleus accumbens 4
brain 2
caudate-putamen 1
frontal cortex 1
Cck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 24 100.00 Very High Very High Very High
Cholecystokinin 18 100.00 Very High Very High Very High
Nucleus accumbens 12 100.00 Very High Very High Very High
substance P 8 100.00 Very High Very High Very High
Neuropeptide 6 99.08 Very High Very High Very High
agonist 1 74.12 Quite High
Dopamine 1 70.20 Quite High
antagonist 1 69.36 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 16 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neuropeptide metabolism on intact, regional brain slices: effect of dopaminergic agents on substance P, cholecystokinin and Met-enkephalin degradation.
Regulation (effect) of Protein_catabolism (degradation) of cholecystokinin in brain associated with neuropeptide, enkephalin, cholecystokinin and substance p
1) Confidence 0.38 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 7543572 Disease Relevance 0.06 Pain Relevance 0.97
CCK 8-(sulfated) degradation on slices from caudate-putamen, nucleus accumbens, and frontal cortex was not altered by inhibitors of neutral endopeptidase 24.11, metalloendopeptidase 24.15, angiotensin converting enzyme, or thiol proteases.
Neg (not) Regulation (altered) of Protein_catabolism (degradation) of CCK in nucleus accumbens associated with nucleus accumbens, urological neuroanatomy and cholecystokinin
2) Confidence 0.23 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7595577 Disease Relevance 0.42 Pain Relevance 0.85
CCK 8-(sulfated) degradation on slices from caudate-putamen, nucleus accumbens, and frontal cortex was not altered by inhibitors of neutral endopeptidase 24.11, metalloendopeptidase 24.15, angiotensin converting enzyme, or thiol proteases.
Neg (not) Regulation (altered) of in frontal cortex Protein_catabolism (degradation) of CCK in nucleus accumbens associated with nucleus accumbens, urological neuroanatomy and cholecystokinin
3) Confidence 0.08 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7595577 Disease Relevance 0.42 Pain Relevance 0.85
CCK 8-(sulfated) degradation on slices from caudate-putamen, nucleus accumbens, and frontal cortex was not altered by inhibitors of neutral endopeptidase 24.11, metalloendopeptidase 24.15, angiotensin converting enzyme, or thiol proteases.
Neg (not) Regulation (altered) of in caudate-putamen Protein_catabolism (degradation) of CCK in nucleus accumbens associated with nucleus accumbens, urological neuroanatomy and cholecystokinin
4) Confidence 0.08 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7595577 Disease Relevance 0.42 Pain Relevance 0.85

General Comments

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