INT49210

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Context Info
Confidence 0.60
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 8
Total Number 8
Disease Relevance 3.48
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (GAD1) plasma membrane (GAD1) intracellular (GAD1)
Anatomy Link Frequency
putamen 1
cerebrospinal fluid 1
striatum 1
CeA 1
pallidum 1
GAD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 68 100.00 Very High Very High Very High
Enkephalin 5 100.00 Very High Very High Very High
GABAergic 66 99.14 Very High Very High Very High
amygdala 10 96.84 Very High Very High Very High
tolerance 1 95.88 Very High Very High Very High
Nicotine 14 95.40 Very High Very High Very High
Nucleus accumbens 1 93.84 High High
Neuropeptide 2 93.68 High High
Morphine 2 93.36 High High
Dynorphin 1 92.64 High High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 51 100.00 Very High Very High Very High
Schizophrenia 107 98.92 Very High Very High Very High
Disease 14 97.72 Very High Very High Very High
Dyskinesias 8 97.56 Very High Very High Very High
Impaired Glucose Tolerance 1 95.88 Very High Very High Very High
Nicotine Addiction 69 94.68 High High
Eating Disorder 1 86.32 High High
Stress 10 85.60 High High
Anxiety Disorder 21 82.92 Quite High
Depression 14 82.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Design of the WebGAD Trial
Transcription (Design) of WebGAD
1) Confidence 0.60 Published 2010 Journal BMC Psychiatry Section Body Doc Link PMC2848219 Disease Relevance 0.31 Pain Relevance 0.07
Expression of glutamic acid decarboxylase mRNA in striatum and pallidum in an animal model of tardive dyskinesia.
Transcription (Expression) of glutamic acid decarboxylase in striatum associated with enkephalin and dyskinesias
2) Confidence 0.53 Published 1995 Journal Exp. Neurol. Section Title Doc Link 7544289 Disease Relevance 0.53 Pain Relevance 0.17
Alterations in prodynorphin, proenkephalin, and GAD67 mRNA levels in the aged human putamen: correlation with Parkinson's disease.
Transcription (levels) of GAD67 in putamen associated with enkephalin and disease
3) Confidence 0.46 Published 2007 Journal J. Neurosci. Res. Section Title Doc Link 17203488 Disease Relevance 0.56 Pain Relevance 0.38
To quantify relative mRNA levels of GAD67, TaqMan real-time RT-PCR was performed on a random sample of large and small airway samples of 10 healthy nonsmokers and 12 healthy smokers that had been used for the HG-U133 Plus 2.0 microarray analyses.
Transcription (levels) of GAD67 associated with nicotine addiction
4) Confidence 0.45 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.09 Pain Relevance 0.04
No antibody against glutamic acid decarboxylase was detected in either the patient's serum or cerebrospinal fluid (CSF).
Transcription (detected) of glutamic acid decarboxylase in cerebrospinal fluid
5) Confidence 0.18 Published 1998 Journal Rinsho Shinkeigaku Section Abstract Doc Link 10203978 Disease Relevance 0.31 Pain Relevance 0.29
Expression of glutamic acid decarboxylase mRNA in striatum and pallidum in an animal model of tardive dyskinesia.
Transcription (Expression) of glutamic acid decarboxylase in pallidum associated with enkephalin and dyskinesias
6) Confidence 0.18 Published 1995 Journal Exp. Neurol. Section Title Doc Link 7544289 Disease Relevance 0.53 Pain Relevance 0.17
Thereafter, changes in the expression of glutamic acid decarboxylase (GAD)67 mRNA were estimated by in situ hybridization in the central nucleus of the amygdala (CeA), basolateral amygdala (BLA), dorsolateral striatum (dLStr), nucleus accumbens shell (AcS) and core (AcC).
Transcription (expression) of GAD in CeA associated with nucleus accumbens, generalized anxiety disorder and amygdala
7) Confidence 0.04 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18312583 Disease Relevance 0.42 Pain Relevance 0.61
In schizophrenia, GABAergic dysfunction, decreased levels of the mRNA expression of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD67), and a reduction of GABAergic interneurons are all observed (Benes 1998; Knable et al. 2002; Lewis et al. 2005).
Transcription (expression) of GAD67 in interneurons associated with gaba, gabaergic and schizophrenia
8) Confidence 0.04 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2806533 Disease Relevance 0.72 Pain Relevance 0.33

General Comments

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