INT49214

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1993
Last Reported 2011
Negated 9
Speculated 4
Reported most in Body
Documents 269
Total Number 273
Disease Relevance 154.22
Pain Relevance 34.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T cells 121
lymphocytes 12
B cells 8
blood 7
spleen 4
Cd4 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 2570 100.00 Very High Very High Very High
Inflammatory response 184 100.00 Very High Very High Very High
Multiple sclerosis 717 99.84 Very High Very High Very High
Morphine 26 99.82 Very High Very High Very High
qutenza 19 99.82 Very High Very High Very High
cytokine 2801 99.80 Very High Very High Very High
Inflammation 2380 99.76 Very High Very High Very High
Acupuncture 120 99.72 Very High Very High Very High
withdrawal 30 99.72 Very High Very High Very High
Central nervous system 326 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 2589 100.00 Very High Very High Very High
INFLAMMATION 2562 100.00 Very High Very High Very High
Apoptosis 726 100.00 Very High Very High Very High
Influenza Virus Infection 391 100.00 Very High Very High Very High
Hematological Disease 197 100.00 Very High Very High Very High
Adhesions 160 100.00 Very High Very High Very High
Atherosclerotic Plaque 72 100.00 Very High Very High Very High
Hyperplasia 62 100.00 Very High Very High Very High
Cytomegalovirus Infection 779 99.98 Very High Very High Very High
Targeted Disruption 623 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of naive (CD62Lhigh CD44low) and effector/memory (CD62Llow CD44high) T cells showed a percent decrease, independent of the expression of CD4 or CD8 molecules.
Gene_expression (expression) of CD4 in T cells
1) Confidence 0.78 Published 2005 Journal J. Leukoc. Biol. Section Abstract Doc Link 15542542 Disease Relevance 1.60 Pain Relevance 0.22
Transfer of CD4(+) T, but not B lymphocytes, normalized visceral pain in these mice.
Gene_expression (Transfer) of CD4 in B lymphocytes
2) Confidence 0.76 Published 2006 Journal Gastroenterology Section Body Doc Link 16697736 Disease Relevance 0.09 Pain Relevance 0
Adaptive transfer of SOCS3Tg-CD4(+) T cells into T and B cell-deficient RAG-2(-/-) mice resulted in an exacerbated liver injury relative to the control.
Gene_expression (transfer) of CD4 in RAG associated with injury
3) Confidence 0.75 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17339476 Disease Relevance 0.89 Pain Relevance 0.64
Furthermore, expression levels of surface Ig, CD3, CD4, and CD8, were similar in spleen cells from control or morphine-treated mice.
Gene_expression (expression) of CD4 in spleen associated with morphine
4) Confidence 0.70 Published 1995 Journal Immunol. Invest. Section Abstract Doc Link 7622200 Disease Relevance 0.25 Pain Relevance 0.73
In all 11 patients, as expected, CD3-positive cells were abundant in the synovial membrane, and a majority of the CD3-positive cells also expressed CD4 (Figure 1).
Gene_expression (expressed) of CD4
5) Confidence 0.69 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212553 Disease Relevance 0.20 Pain Relevance 0.04
Morphine (administered as subcutaneous implants) had profound inhibitory effects on the development of alloreactivity manifested as a suppression of: (1) lymph node hyperplasia, (2) mixed lymphocyte reactivity (MLR) in PLN cells and (3) the number of CD4+ and Thy 1.2 lymphoid subsets.
Gene_expression (suppression) of CD4 in PLN associated with hyperplasia and morphine
6) Confidence 0.68 Published 1995 Journal Immunopharmacology Section Abstract Doc Link 7775160 Disease Relevance 0.18 Pain Relevance 1.03
These infiltrating leukocytes contained predominantly CD4(+) but not CD8(+) T lymphocytes.
Neg (not) Gene_expression (contained) of CD4 in T lymphocytes
7) Confidence 0.67 Published 2008 Journal Eur. J. Immunol. Section Abstract Doc Link 18196515 Disease Relevance 0.41 Pain Relevance 0.33
The PG-specific and arthritogenic T cell hybridoma (5/4E8) expressed TCR-alpha beta + (V beta 4), CD4+, and CD8- phenotypes and belonged to the Th1 subset, as the cells secreted IL-2 and IFN-gamma, but not IL-4 upon PG stimulation, and the response was MHC class II (I-Ad)-restricted.
Gene_expression (expressed) of CD4 in T cell
8) Confidence 0.67 Published 1995 Journal J. Immunol. Section Abstract Doc Link 7544381 Disease Relevance 0.62 Pain Relevance 0.23
Transfer activity was lost when cells were depleted of CD4(+) or CD25(+) subpopulations.
Gene_expression (depleted) of CD4
9) Confidence 0.66 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15879089 Disease Relevance 0.39 Pain Relevance 0.14
expression for both CD4 SP and CD8 SP thymocytes, and decreased frequency of post-positive selection TCR?
Gene_expression (expression) of CD4 in thymocytes
10) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.16 Pain Relevance 0
Furthermore, a very high proportion of these circulating T cells showed an immature phenotype (i.e. 13.2% of PNA+CD3+ cells in stressed mice versus 1.3% in control mice) but they are not CD4+CD8+ thymocytes.
Neg (not) Gene_expression (thymocytes) of CD4 in thymocytes
11) Confidence 0.66 Published 2001 Journal BMC Immunol Section Body Doc Link PMC37547 Disease Relevance 0.35 Pain Relevance 0
CD4 expression in the CD3int cells was higher than in the CD3high cells (Fig. 5C).
Gene_expression (expression) of CD4
12) Confidence 0.66 Published 2007 Journal Virol J Section Body Doc Link PMC1810241 Disease Relevance 1.17 Pain Relevance 0
For generation of iTregs, CD4+ cells were isolated from B6 spleen and lymph nodes by magnetic bead sorting (L3T4 microbeads; Miltenyi Biotec), and were cultured for 5 days in plates coated with 10 ?
Gene_expression (microbeads) of L3T4 in lymph nodes
13) Confidence 0.65 Published 2010 Journal American Journal of Transplantation Section Body Doc Link PMC2856406 Disease Relevance 0.06 Pain Relevance 0
In addition, the ability of D. andersoni infestation to program specific CD4 T cell expression of IL-4 was significantly reduced during the second infestation.
Gene_expression (expression) of CD4 in T cell
14) Confidence 0.65 Published 2009 Journal Parasit Vectors Section Body Doc Link PMC2764639 Disease Relevance 0.06 Pain Relevance 0
This result suggests that a penetrating ocular injury at an early stage after an AC injection of OVA does not alter the expression of CD4+CD25+Foxp3+T cells and thereby does not result in the induction of ACAID.
Gene_expression (expression) of CD4+ in T cells associated with ocular injury
15) Confidence 0.65 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2255028 Disease Relevance 0.59 Pain Relevance 0.03
In our study, we have demonstrated that repetitive PTx treatment elevated frequency as well as mean FoxP3 expression of CD4+CD25+FoxP3+ T cells.
Gene_expression (expression) of CD4 in T cells
16) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.65 Pain Relevance 0.18
As shown in figure 4e, repetitive PTx treatment gradually elevated the frequency of splenic CD4+CD25+FoxP3+ Treg as well as the mean FoxP3 expression of CD4+CD25+ T cells, starting as early as 3 weeks after initiation of PTx treatment.
Gene_expression (expression) of CD4 in T cells
17) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.32 Pain Relevance 0.18
Absence of 5-LO does not alter the development of IFN-gamma producing Th1-type CD4(+) T cells or IL-17 producing CD4(+) T cells.
Gene_expression (producing) of CD4 in T cells
18) Confidence 0.64 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18048478 Disease Relevance 0.87 Pain Relevance 0.65
We found that the general patterns of CD4+ T cell percentages (Figure 2A) are somewhat similar to those of CD8+ T cells (Figure 2B) during the induction and expression of ACAID.
Gene_expression (expression) of CD4 in T cells
19) Confidence 0.64 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605729 Disease Relevance 0.23 Pain Relevance 0.03
Lastly, we observed an expansion of CD4+CD25+FoxP3+ Treg during the induction of ACAID.
Gene_expression (expansion) of CD4
20) Confidence 0.64 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605729 Disease Relevance 0.27 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox