INT49217

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Context Info
Confidence 0.41
First Reported 1995
Last Reported 2008
Negated 1
Speculated 2
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 3.64
Pain Relevance 4.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (KNG1) extracellular region (KNG1) plasma membrane (KNG1)
Anatomy Link Frequency
Platelet 2
DRG 2
neck muscles 2
KNG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 88 100.00 Very High Very High Very High
substance P 12 100.00 Very High Very High Very High
qutenza 10 100.00 Very High Very High Very High
Calcitonin gene-related peptide 1 99.52 Very High Very High Very High
dorsal root ganglion 7 99.40 Very High Very High Very High
antagonist 19 94.88 High High
Pain 34 94.12 High High
cva 9 90.48 High High
Neuropeptide 5 89.88 High High
b2 receptor 2 88.72 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 8 99.40 Very High Very High Very High
Pressure And Volume Under Development 34 99.24 Very High Very High Very High
Hereditary Angioedema 62 97.88 Very High Very High Very High
Injury 11 97.40 Very High Very High Very High
Pain 28 94.12 High High
Heart Rate Under Development 21 92.84 High High
Sprains And Strains 1 92.00 High High
Complex Regional Pain Syndromes 3 91.96 High High
Increased Venous Pressure Under Development 56 91.36 High High
Thrombosis 4 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Enalaprilat induced a significant increase in bradykinin levels in the dialysate, without affecting kallidin levels.
Positive_regulation (induced) of Positive_regulation (increase) of bradykinin associated with bradykinin
1) Confidence 0.41 Published 2005 Journal J. Appl. Physiol. Section Abstract Doc Link 15475593 Disease Relevance 0.29 Pain Relevance 0.43
The thromboxane A2 receptor (TP receptor) antagonist GR32191 ((1R-(1 alpha(Z),2 beta,3 beta,5 alpha))-(+)-7-(5-(((1,1'-biphenyl)-4-yl)- methoxy)-3-hydroxy-2-(1-piperidinyl)cyclopentyl)-4-heptenoic acid, hydrochloride) (10(-10) to 10(-8) M) dose dependently inhibited the effect of bradykinin, suggesting the mediation of the TP receptor in the action of bradykinin.
Positive_regulation (mediation) of Positive_regulation (action) of bradykinin associated with antagonist and bradykinin
2) Confidence 0.36 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7545124 Disease Relevance 0 Pain Relevance 0.57
Such an effect appears to be mediated primarily by bradykinin accumulation.
Positive_regulation (mediated) of Positive_regulation (accumulation) of bradykinin associated with bradykinin
3) Confidence 0.31 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.42 Pain Relevance 0.19
Accumulation of bradykinin via inhibition of ACE may increase NO synthesis or activity, resulting in improved vasodilative response.
Neg (NO) Spec (may) Positive_regulation (increase) of Positive_regulation (Accumulation) of bradykinin associated with bradykinin
4) Confidence 0.31 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.31 Pain Relevance 0.22
Platelet aggregation may also be suppressed through increased prostacyclin induced by elevated bradykinin levels.


Positive_regulation (induced) of Positive_regulation (elevated) of bradykinin in Platelet associated with bradykinin
5) Confidence 0.31 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.41 Pain Relevance 0.13
Increased intramuscular concentration of bradykinin increases the static fusimotor drive to muscle spindles in neck muscles of the cat.
Positive_regulation (increases) of Positive_regulation (Increased) of bradykinin in neck muscles associated with bradykinin
6) Confidence 0.29 Published 1997 Journal Pain Section Title Doc Link 9106812 Disease Relevance 0.07 Pain Relevance 0.31
All of the patients showed a markedly increased level of bradykinin as well as calcitonin gene-related peptide.
Positive_regulation (increased) of Positive_regulation (increased) of bradykinin associated with bradykinin and calcitonin gene-related peptide
7) Confidence 0.27 Published 1998 Journal Acta Orthop Belg Section Abstract Doc Link 9922551 Disease Relevance 0.45 Pain Relevance 0.48
Decreased levels of C1-INH are believed to allow increased activation of the kallikrein cascade leading to an increase in bradykinin as a mechanism of angioedema.
Positive_regulation (allow) of Positive_regulation (increase) of bradykinin associated with pressure and volume under development and bradykinin
8) Confidence 0.07 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621399 Disease Relevance 0.77 Pain Relevance 0.09
Several studies have emphasized the possible role of elevated bradykinin levels resulting from ACE inhibitor therapy.
Spec (possible) Positive_regulation (resulting) of Spec (possible) Positive_regulation (elevated) of bradykinin associated with bradykinin
9) Confidence 0.05 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.31 Pain Relevance 0.24
Interestingly, the inositol 1,4,5-triphosphate (IP3)-induced calcium release blocker [2-aminoethyl diphenylborinate (2-APB)] not only inhibited the potassium-evoked SP release, but also completely abolished the enhancement of capsaicin-induced SP release by bradykinin from cultured DRG neurons.
Positive_regulation (enhancement) of Positive_regulation (capsaicin-induced) of bradykinin in DRG associated with dorsal root ganglion, qutenza, bradykinin and substance p
10) Confidence 0.03 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16696851 Disease Relevance 0.61 Pain Relevance 1.51

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