INT49219

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Context Info
Confidence 0.75
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 28
Total Number 28
Disease Relevance 13.77
Pain Relevance 14.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Hrh1) plasma membrane (Hrh1) nucleus (Hrh1)
cytoplasm (Hrh1) signal transducer activity (Hrh1)
Anatomy Link Frequency
neurons 3
bladder 2
NIH-3T3 1
tail 1
fibroblasts 1
Hrh1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 58 100.00 Very High Very High Very High
Kappa opioid receptor 8 100.00 Very High Very High Very High
intrathecal 12 99.98 Very High Very High Very High
Hyperalgesia 27 99.96 Very High Very High Very High
cINOD 9 99.92 Very High Very High Very High
Pain 131 99.76 Very High Very High Very High
Morphine 16 99.36 Very High Very High Very High
diclofenac 2 99.36 Very High Very High Very High
imagery 10 99.28 Very High Very High Very High
allodynia 10 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bordatella Infection 53 100.00 Very High Very High Very High
Hyperalgesia 29 99.96 Very High Very High Very High
Neuroblastoma 2 99.84 Very High Very High Very High
Cough 2 99.70 Very High Very High Very High
Neuropathic Pain 30 99.28 Very High Very High Very High
Ganglion Cysts 13 98.96 Very High Very High Very High
Bladder Cancer 19 98.84 Very High Very High Very High
INFLAMMATION 173 96.88 Very High Very High Very High
Pain 130 96.84 Very High Very High Very High
Reprotox - General 3 120 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A subset of these neurons expressed the histamine H1 receptor.
Gene_expression (expressed) of histamine H1 receptor in neurons
1) Confidence 0.75 Published 2006 Journal Neuron Section Abstract Doc Link 17114052 Disease Relevance 0.07 Pain Relevance 0.41
RT-PCR indicated the expression of all four histamine receptors (H1R, H2R, H3R, H4R) in mouse DRG.
Gene_expression (expression) of H1R in DRG associated with dorsal root ganglion
2) Confidence 0.72 Published 2010 Journal Neuroscience Section Abstract Doc Link 20006972 Disease Relevance 1.02 Pain Relevance 0.91
We have previously demonstrated that the intrathecal administration of pertussis toxin produces a long-lasting thermal allodynia in mice.
Gene_expression (produces) of pertussis toxin associated with bordatella infection, allodynia and intrathecal
3) Confidence 0.70 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10884555 Disease Relevance 0.65 Pain Relevance 0.76
Moreover, histamine provoked inward currents when histamine receptor subtype 1 (H1R) and TRPV1 were expressed heterologously, but not when H1R or TRPV1 was expressed alone.
Gene_expression (expressed) of histamine receptor subtype 1
4) Confidence 0.69 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17329430 Disease Relevance 0.22 Pain Relevance 0.08
Moreover, histamine provoked inward currents when histamine receptor subtype 1 (H1R) and TRPV1 were expressed heterologously, but not when H1R or TRPV1 was expressed alone.
Gene_expression (expressed) of H1R
5) Confidence 0.69 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17329430 Disease Relevance 0.22 Pain Relevance 0.08
Moreover, histamine provoked inward currents when histamine receptor subtype 1 (H1R) and TRPV1 were expressed heterologously, but not when H1R or TRPV1 was expressed alone.
Gene_expression (expressed) of H1R
6) Confidence 0.69 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17329430 Disease Relevance 0.22 Pain Relevance 0.07
The potentiating effect of histamine was mimicked by an H1R agonist, but not H2R-H4R agonists and was inhibited only by an H1R antagonist.
Gene_expression (agonist) of H1R associated with antagonist and agonist
7) Confidence 0.63 Published 2010 Journal Neuroscience Section Abstract Doc Link 20006972 Disease Relevance 1.00 Pain Relevance 0.91
The efficacy of anti-H1R and anti-H2R therapies was not likely due to non-specific effects of these drugs on pelvic sensitivity or behavior because no significant change in baseline tactile sensitivity or free-roaming behaviors were detected (Fig. 3 and Tables S1 and S2).
Gene_expression (therapies) of H1R
8) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346452 Disease Relevance 1.01 Pain Relevance 0.98
Intrathecal pertussis toxin produces hyperalgesia and allodynia in mice.
Gene_expression (produces) of pertussis toxin associated with hyperalgesia, bordatella infection, allodynia and intrathecal
9) Confidence 0.51 Published 1997 Journal Pain Section Title Doc Link 9150297 Disease Relevance 0.40 Pain Relevance 1.14
Seven days after a single injection of pertussis toxin, inhibition of morphine and diphenhydramine analgesia was observed, whereas 11 days after pertussis toxin pretreatment, baclofen- and clomipramine-induced antinociception was also reduced.
Gene_expression (injection) of pertussis toxin associated with antinociception, bordatella infection, analgesia and morphine
10) Confidence 0.50 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8840123 Disease Relevance 0.52 Pain Relevance 0.89
Quantitative RT-PCR revealed that histamine receptors 1, 2, 3 and 4 are expressed in the bladder and the colon (Fig.
Gene_expression (expressed) of histamine receptors 1 in bladder
11) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346452 Disease Relevance 1.27 Pain Relevance 1.40
In contrast to H1R, H2R, and H4R, H3R are mainly expressed in neurons of the central and peripheral nervous system [16].
Gene_expression (expressed) of H1R in neurons associated with peripheral nervous system
12) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696087 Disease Relevance 0.26 Pain Relevance 0.41
We found that donepezil may restore the proper balance between H1R and H2R expression (Leszek et al 2004).
Gene_expression (expression) of H1R
13) Confidence 0.23 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654796 Disease Relevance 0.69 Pain Relevance 0.21
Dual coupling of cloned human 5-hydroxytryptamine1D alpha and 5-hydroxytryptamine1D beta receptors stably expressed in murine fibroblasts: inhibition of adenylate cyclase and elevation of intracellular calcium concentrations via pertussis toxin-sensitive G protein(s).
Gene_expression (sensitive) of pertussis toxin in fibroblasts associated with bordatella infection
14) Confidence 0.18 Published 1993 Journal Mol. Pharmacol. Section Title Doc Link 8396718 Disease Relevance 0.10 Pain Relevance 0.24
Intrathecal injection of pertussis toxin (0.25 and 0.50 micrograms) in mice inhibited nicotine-induced antinociception in the tail-flick test.
Gene_expression (injection) of pertussis toxin in tail associated with antinociception, bordatella infection, nicotine, tail-flick and intrathecal
15) Confidence 0.17 Published 1994 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8029303 Disease Relevance 0.19 Pain Relevance 0.66
In mice pretreated with pertussis toxin, 2 microgram/mouse, given i.c.v. 72 h before the agonists, the decrease in cGMP induced by Dex or F was not affected, while the stimulatory effect of F was reversed to an inhibitory effect.
Gene_expression (pretreated) of pertussis toxin associated with bordatella infection and agonist
16) Confidence 0.09 Published 1998 Journal Brain Res. Section Abstract Doc Link 9824660 Disease Relevance 0.10 Pain Relevance 0.55
An effect also produced by pertussis toxin, agent impairing the function of Gi/GO transducer proteins.
Gene_expression (produced) of pertussis toxin associated with bordatella infection
17) Confidence 0.07 Published 1994 Journal Life Sci. Section Abstract Doc Link 7968256 Disease Relevance 0.35 Pain Relevance 0.89
METHOD: EAE was induced in 8 to 10 week old C57BL/6 female mice with an emulsion of MOG35-55, Complete Freund Adjuvant, Mycobacterium tuberculosis H37 RA and pertussis toxin.
Gene_expression (emulsion) of pertussis toxin
18) Confidence 0.05 Published 2009 Journal Arq Neuropsiquiatr Section Body Doc Link 19330217 Disease Relevance 0 Pain Relevance 0
Pertussis toxin (50 micrograms/l) did not modify the effect of indometacin, mefenamic acid, and tolmetin, but partially antagonized the effects of diclofenac and naproxen and increased the effect of phenylbutazone and piroxicam.
Gene_expression (antagonized) of Pertussis toxin associated with bordatella infection and diclofenac
19) Confidence 0.04 Published 1995 Journal Pharmacology Section Abstract Doc Link 7545306 Disease Relevance 0.24 Pain Relevance 0.71
On the other hand, in CHO cells co-expressing the kappa-opioid receptor and pertussis toxin-insensitive chimeric alpha(i2)/alpha(q) subunits without alpha(i2) residues Met244-Asn331, pretreatment with pertussis toxin completely blocked these acute and sustained effects of U69,593 on cAMP accumulation.
Gene_expression (co-expressing) of pertussis toxin associated with bordatella infection and kappa opioid receptor
20) Confidence 0.02 Published 1999 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10669040 Disease Relevance 0.36 Pain Relevance 0.54

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