INT4922

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Context Info
Confidence 0.57
First Reported 1988
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 13.97
Pain Relevance 3.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (MET) signal transduction (MET) plasma membrane (MET)
Anatomy Link Frequency
HGF 4
caudate nucleus 1
cerebrospinal fluid 1
mesothelial cell 1
lacrimal 1
MET (Homo sapiens)
MET - A2M (1)
Pain Link Frequency Relevance Heat
Enkephalin 30 100.00 Very High Very High Very High
substance P 5 99.50 Very High Very High Very High
Morphine 4 99.24 Very High Very High Very High
Dopamine 1 99.16 Very High Very High Very High
Opioid 3 98.12 Very High Very High Very High
Neuropeptide 3 92.40 High High
imagery 7 91.60 High High
Endogenous opioid 2 87.80 High High
cytokine 5 86.48 High High
mu opioid receptor 4 79.60 Quite High
Disease Link Frequency Relevance Heat
Cancer 260 99.80 Very High Very High Very High
Cirrhosis 293 99.76 Very High Very High Very High
Disease 101 99.76 Very High Very High Very High
Fibrosis 45 99.64 Very High Very High Very High
Adhesions 8 99.48 Very High Very High Very High
Dog Diseases 5 99.28 Very High Very High Very High
Hepatitis 169 99.20 Very High Very High Very High
Chronic Hepatitis 157 99.16 Very High Very High Very High
Toxicity 3 99.12 Very High Very High Very High
Disorders Of The Lacrimal System 3 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decrease in caudate nucleus SP levels might be related to the decrease in nigral SP levels in PD, while the reduction in Met-enk levels appears to be a feature of a subgroup of parkinsonian patients.
Negative_regulation (reduction) of Met in caudate nucleus associated with parkinson's disease, disease and substance p
1) Confidence 0.57 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1281532 Disease Relevance 0.71 Pain Relevance 0.36
The IL-2 single administration results in a significant decrease of Met-Enk in serum.
Negative_regulation (decrease) of Met
2) Confidence 0.57 Published 2000 Journal J. Exp. Clin. Cancer Res. Section Abstract Doc Link 10840936 Disease Relevance 0.17 Pain Relevance 0.46
An alteration of the central noradrenergic activity and the opioid system can be assumed because of increased dopamine beta-hydroxylase (D beta H) activity and decreased methionine-enkephalin (Met-Enk) levels in the cerebrospinal fluid (CSF).
Negative_regulation (decreased) of Met in cerebrospinal fluid associated with dopamine, enkephalin and opioid
3) Confidence 0.42 Published 1988 Journal Acta Neurol Belg Section Abstract Doc Link 3176874 Disease Relevance 0.40 Pain Relevance 0.37
Whereas, breakdown of [Met]enkephalin and [Leu]enkephalin is essentially complete in less than one min when incubated at 37 degree C with purified aminopeptidase M (EC3.4.11.2; substrate:enzyme = 1:0.1) in Tris buffer (pH 7.02), the corresponding phospho analogs are still detected 60 min after start of incubation.
Negative_regulation (breakdown) of Met associated with enkephalin
4) Confidence 0.42 Published 1996 Journal Life Sci. Section Abstract Doc Link 8622556 Disease Relevance 0 Pain Relevance 0.79
The mechanism by which the inhibitory effect of d-ala2-met-enkephalinamide (DALA) on lacrimal acinar adenylyl cyclase is exerted was assessed in membrane preparations by a cAMP protein binding assay.
Negative_regulation (effect) of met (A2M) in lacrimal associated with disorders of the lacrimal system
5) Confidence 0.42 Published 1992 Journal Life Sci. Section Abstract Doc Link 1732703 Disease Relevance 0.47 Pain Relevance 0.07
Blockade of elevated [Met]enkephalin by a cysteine protease inhibitor of PTP.
Negative_regulation (Blockade) of Met associated with enkephalin
6) Confidence 0.41 Published 1995 Journal J. Biol. Chem. Section Title Doc Link 7768928 Disease Relevance 0 Pain Relevance 0.48
Also, the aminopeptidase M activity on Met-enk can be inhibited in the presence of Ac-Met-enk, which acts as a mixed-type inhibitor with the inhibition constant (K(i)) of I x 10(-3) M.
Negative_regulation (inhibited) of Met
7) Confidence 0.41 Published 1999 Journal Peptides Section Abstract Doc Link 10503775 Disease Relevance 0 Pain Relevance 0.39
The reduced c-MET protein levels indicate a utilization of c-MET which is degraded through endocytosis after phosphorylation.
Negative_regulation (reduced) of c-MET protein
8) Confidence 0.29 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.42 Pain Relevance 0
The c-MET mRNA levels in all groups were significantly decreased towards control, with a maximum four-fold reduction in AH (Figure 2B).
Negative_regulation (decreased) of c-MET associated with hepatitis
9) Confidence 0.29 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.88 Pain Relevance 0.03
Total c-MET protein levels are similarly reduced as the mRNA levels.
Negative_regulation (reduced) of c-MET protein
10) Confidence 0.29 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.75 Pain Relevance 0.03
studies have shown that MET inhibition results in low-grade toxicity, in
Negative_regulation (inhibition) of MET associated with toxicity
11) Confidence 0.28 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.55 Pain Relevance 0.03
The increased mRNA levels of HGF and the decreased levels of c-MET mRNA in fibrotic canine diseases (CH, LDH, and CIRR), were in line with publications from human samples [20].
Negative_regulation (decreased) of c-MET in HGF associated with dog diseases, fibrosis, chronic hepatitis and cirrhosis
12) Confidence 0.21 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.40 Pain Relevance 0
In all canine groups, levels of c-MET mRNA (proto-oncogenic receptor for HGF) were significantly decreased (p < 0.05).
Negative_regulation (decreased) of c-MET in HGF
13) Confidence 0.21 Published 2007 Journal Comp Hepatol Section Abstract Doc Link PMC1971050 Disease Relevance 2.02 Pain Relevance 0.03
This clearly contrasts with the cHCC, where HGF-induced growth is absent (data not shown), most likely because of severely reduced c-MET levels.
Negative_regulation (reduced) of c-MET in HGF
14) Confidence 0.15 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC535891 Disease Relevance 0.32 Pain Relevance 0.03
As shown in Figure 5, c-MET, a receptor tyrosine kinase involved in cell survival and growth, was down-regulated 33-fold compared to the control group.
Negative_regulation (regulated) of c-MET
15) Confidence 0.13 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC535891 Disease Relevance 0.38 Pain Relevance 0.03
Thus, inhibition of stromal-produced HGF or the subsequent activation of c-Met signaling via c-Met inhibitors may represent additional approaches to target CSCs [92].


Negative_regulation (inhibitors) of c-Met in HGF
16) Confidence 0.05 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC2958340 Disease Relevance 0.37 Pain Relevance 0
The obvious function of the Msr system is to reduce methionine sulfoxide (Met(o)) in proteins back to methionine (Met) (reviewed in [23]), although it also functions as part of a ROS scavenger system, in which the Msr system permits Met residues in protein to function as catalytic antioxidants [24].
Negative_regulation (reduce) of Met
17) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2686156 Disease Relevance 0.73 Pain Relevance 0.11
This study aimed to investigate whether human mesothelial cells express MOR-1; if so, such could constitute a site of action for morphine in adhesion prevention. 2 Cells from Met-5A, a human mesothelial cell line were seeded and prepared for immunocytochemistry and Western blotting. 3 Immunocytochemistry showed MOR-1 expression in mesothelial cells, predominantly in the nuclei.
Negative_regulation (prepared) of Met-5A in mesothelial cell associated with adhesions and morphine
18) Confidence 0.02 Published 2009 Journal Auton Autacoid Pharmacol Section Abstract Doc Link 19740087 Disease Relevance 0.57 Pain Relevance 0.49
OPN transcript expression in Met and Db cell lines and tumors
Negative_regulation (lines) of Met associated with cancer
19) Confidence 0.02 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.84 Pain Relevance 0

General Comments

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