INT49235

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Context Info
Confidence 0.81
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.69
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (DNASE1) extracellular region (DNASE1) nucleus (DNASE1)
Anatomy Link Frequency
lymphocytes 1
blast cell 1
DNASE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
halothane 5 99.66 Very High Very High Very High
anesthesia 10 98.08 Very High Very High Very High
Angina 1 54.36 Quite High
Pain 2 47.12 Quite Low
Inflammation 5 5.00 Very Low Very Low Very Low
iatrogenic 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cough 5 98.36 Very High Very High Very High
Empyema 43 98.00 Very High Very High Very High
Suppuration 10 97.46 Very High Very High Very High
Bronchiectasis 2 96.36 Very High Very High Very High
Adhesions 1 81.80 Quite High
Dyspnea 2 78.48 Quite High
Infection 22 71.68 Quite High
Congenital Anomalies 3 64.32 Quite High
Disease 6 60.24 Quite High
Polio 1 59.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The released DNase activities do not originate from dead cells and are not influenced by blast cell formation.
Localization (released) of DNase in blast cell
1) Confidence 0.81 Published 1995 Journal Z. Naturforsch., C, J. Biosci. Section Abstract Doc Link 7546035 Disease Relevance 0 Pain Relevance 0.21
Recently there has been an interest in intrapleural DNase as a possible candidate in combination with thrombolytic therapy to enhance pus drainage.44 In an animal model, the combination of recombinant tissue plasminogen activator (alteplase) and recombinant human deoxyribonnuclease (rhDNase) has been shown to be more effective in treating empyema than either agent used alone.45 Successful treatment of human empyema with intrapleural rhDNase given after intrapleural fibrinolytic therapy has been described in at least one case report.46
Localization (deoxyribonnuclease) of DNase associated with suppuration and empyema
2) Confidence 0.73 Published 2010 Journal Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine Section Body Doc Link PMC2998927 Disease Relevance 0.98 Pain Relevance 0.05
The electrophoretic mobility of the released neutral DNase activity is in accordance with DNase I and the electrophoretic mobility of the released acid DNase activity with DNase II.
Localization (released) of DNase
3) Confidence 0.71 Published 1995 Journal Z. Naturforsch., C, J. Biosci. Section Abstract Doc Link 7546035 Disease Relevance 0 Pain Relevance 0.19
The anesthetic halothane can inhibit the released neutral and acid DNase activities.
Localization (released) of DNase associated with halothane
4) Confidence 0.70 Published 1995 Journal Z. Naturforsch., C, J. Biosci. Section Abstract Doc Link 7546035 Disease Relevance 0 Pain Relevance 0.22
After incubation with DNA human lymphocytes release neutral and acid DNase activities into the culture medium; the release depends on DNA concentration and time of cultivation.
Localization (release) of DNase in lymphocytes
5) Confidence 0.70 Published 1995 Journal Z. Naturforsch., C, J. Biosci. Section Abstract Doc Link 7546035 Disease Relevance 0 Pain Relevance 0.17
The electrophoretic mobility of the released neutral DNase activity is in accordance with DNase I and the electrophoretic mobility of the released acid DNase activity with DNase II.
Localization (released) of DNase
6) Confidence 0.62 Published 1995 Journal Z. Naturforsch., C, J. Biosci. Section Abstract Doc Link 7546035 Disease Relevance 0 Pain Relevance 0.20
Such studies will become more complicated by the introduction of new treatments, such as DNase and other therapies that alter secretions, and may begin to change mucociliary or cough clearance.
Localization (secretions) of DNase associated with cough
7) Confidence 0.03 Published 1996 Journal Respir Care Clin N Am Section Abstract Doc Link 9390886 Disease Relevance 0.71 Pain Relevance 0

General Comments

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