INT49242

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Context Info
Confidence 0.38
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 3.79
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mc1r, Pomc) cell-cell signaling (Pomc) cytoplasm (Pomc)
signal transducer activity (Mc1r) pigmentation (Mc1r) extracellular space (Pomc)
Anatomy Link Frequency
melanocyte 6
Mc1r (Mus musculus)
Pomc (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 21 100.00 Very High Very High Very High
Inflammation 13 99.12 Very High Very High Very High
imagery 6 98.92 Very High Very High Very High
Neuropeptide 4 89.36 High High
antagonist 4 75.00 Quite High
agonist 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 14 100.00 Very High Very High Very High
Amelanotic Melanoma 1 99.10 Very High Very High Very High
Infection 6 99.00 Very High Very High Very High
Skin Cancer 67 98.60 Very High Very High Very High
Cancer 60 96.16 Very High Very High Very High
Diabetes Mellitus 1 92.16 High High
Obesity 7 91.64 High High
Syndrome 3 88.72 High High
Appetite Loss 6 86.08 High High
Hyperglycemia 1 83.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Radiolabeled alpha-MSH peptide and its analogs that can specifically bind with MC1R have been extensively explored for developing novel agents for melanoma detection and radionuclide therapy.
MC1R Binding (bind) of alpha-MSH peptide associated with skin cancer
1) Confidence 0.38 Published 2007 Journal Bioconjug. Chem. Section Abstract Doc Link 17348700 Disease Relevance 0.54 Pain Relevance 0.20
Physiologic significance of alphaMSH-MC1R interaction in host defense against infection is discussed.
MC1R Binding (interaction) of alphaMSH associated with melanocortin 1 receptor and infection
2) Confidence 0.36 Published 2007 Journal J. Vet. Med. Sci. Section Abstract Doc Link 17917378 Disease Relevance 0.60 Pain Relevance 0.43
Physiologic significance of alphaMSH-MC1R interaction in host defense against infection is discussed.
MC1R Binding (interaction) of alphaMSH associated with melanocortin 1 receptor and infection
3) Confidence 0.36 Published 2007 Journal J. Vet. Med. Sci. Section Abstract Doc Link 17917378 Disease Relevance 0.60 Pain Relevance 0.43
Agouti has been found to antagonize the binding of certain pro-opiomelanocortin peptides, such as alpha-melanocyte stimulating hormone (alpha-MSH), to the murine melanocortin-1 receptor (MC1-R).
MC1-R Binding (binding) of alpha-melanocyte stimulating hormone in melanocyte associated with melanocortin 1 receptor
4) Confidence 0.35 Published 1995 Journal Biochemistry Section Abstract Doc Link 7547977 Disease Relevance 0 Pain Relevance 0.14
Agouti has been found to antagonize the binding of certain pro-opiomelanocortin peptides, such as alpha-melanocyte stimulating hormone (alpha-MSH), to the murine melanocortin-1 receptor (MC1-R).
MC1-R Binding (binding) of alpha-MSH in melanocyte associated with melanocortin 1 receptor
5) Confidence 0.35 Published 1995 Journal Biochemistry Section Abstract Doc Link 7547977 Disease Relevance 0 Pain Relevance 0.14
Agouti has been found to antagonize the binding of certain pro-opiomelanocortin peptides, such as alpha-melanocyte stimulating hormone (alpha-MSH), to the murine melanocortin-1 receptor (MC1-R).
melanocortin-1 receptor Binding (binding) of alpha-MSH in melanocyte associated with melanocortin 1 receptor
6) Confidence 0.31 Published 1995 Journal Biochemistry Section Abstract Doc Link 7547977 Disease Relevance 0 Pain Relevance 0.14
Alpha-melanocyte-stimulating hormone exerts its antiinflammatory and immunomodulatory effects by binding to the melanocortin-1 receptor, and since T cells are important effectors during immune responses, we investigated the effects of alpha-melanocyte-stimulating hormone on T cell function.


melanocortin-1 receptor Binding (binding) of Alpha-melanocyte-stimulating hormone in melanocyte associated with inflammation and melanocortin 1 receptor
7) Confidence 0.30 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2813861 Disease Relevance 0.40 Pain Relevance 0.28
The secreted agouti protein antagonizes the binding of the alpha-melanocyte-stimulating hormone to its receptor (melanocortin 1 receptor) on the surface of hair bulb melanocytes, causing alterations in intracellular cAMP levels.
melanocortin 1 receptor Binding (binding) of alpha-melanocyte-stimulating hormone in melanocytes associated with melanocortin 1 receptor
8) Confidence 0.27 Published 1997 Journal J. Nutr. Section Abstract Doc Link 9278579 Disease Relevance 1.22 Pain Relevance 0.10
Agouti has been found to antagonize the binding of certain pro-opiomelanocortin peptides, such as alpha-melanocyte stimulating hormone (alpha-MSH), to the murine melanocortin-1 receptor (MC1-R).
melanocortin-1 receptor Binding (binding) of alpha-melanocyte stimulating hormone in melanocyte associated with melanocortin 1 receptor
9) Confidence 0.24 Published 1995 Journal Biochemistry Section Abstract Doc Link 7547977 Disease Relevance 0 Pain Relevance 0.14
Both melanotic and amelanotic melanomas (over-)express the melanocortin-1 receptor (MC1-R), the target for alpha-MSH.
MC1-R Binding (target) of alpha-MSH associated with melanocortin 1 receptor and amelanotic melanoma
10) Confidence 0.02 Published 2007 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 18097939 Disease Relevance 0.43 Pain Relevance 0.15

General Comments

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