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Context Info
Confidence 0.35
First Reported 1995
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.10
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cndp2) peptidase activity (Cndp2) cytoplasm (Cndp2)
Anatomy Link Frequency
cleavage 1
Cndp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 1 98.28 Very High Very High Very High
antinociception 3 87.52 High High
withdrawal 1 79.76 Quite High
Neuropeptide 1 66.16 Quite High
Neurotransmitter 1 61.52 Quite High
opioid receptor 1 58.84 Quite High
Dynorphin 4 26.40 Quite Low
medulla 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Thymoma 1 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, degradation of endomorphin-2 by brain synaptic membranes seems to take place mainly through the cleavage of Pro(2)-Phe(3) bond by dipeptidyl peptidase IV, followed by release of free phenylalanine and PheNH(2) from the liberated fragment, Phe-PheNH(2) by aminopeptidase.
Localization (release) of peptidase in cleavage
1) Confidence 0.35 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12906930 Disease Relevance 0 Pain Relevance 0.35
A secreted dibasic cleaving peptidase capable of converting dynorphins into Leu-enkephalin-Arg6 was purified from the medium of EL-4 mouse thymoma cells.
Localization (secreted) of peptidase associated with thymoma and enkephalin
2) Confidence 0.06 Published 1995 Journal Biochemistry Section Abstract Doc Link 7547986 Disease Relevance 0.10 Pain Relevance 0.10

General Comments

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