INT4925

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Context Info
Confidence 0.48
First Reported 1981
Last Reported 2010
Negated 2
Speculated 5
Reported most in Abstract
Documents 57
Total Number 62
Disease Relevance 17.39
Pain Relevance 38.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tacr1) response to stress (Tacr1) cytoplasm (Tacr1)
signal transducer activity (Tacr1)
Anatomy Link Frequency
spinal cord 9
neurons 6
plasma 3
thymocyte 3
nucleus 2
Tacr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 692 100.00 Very High Very High Very High
Inflammation 163 100.00 Very High Very High Very High
Neuropeptide 30 100.00 Very High Very High Very High
Opioid 23 100.00 Very High Very High Very High
opioid receptor 12 100.00 Very High Very High Very High
Analgesic 11 100.00 Very High Very High Very High
MU agonist 2 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
antagonist 68 99.96 Very High Very High Very High
Clonidine 10 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 30 99.96 Very High Very High Very High
Nociception 56 99.66 Very High Very High Very High
Ganglion Cysts 221 99.56 Very High Very High Very High
INFLAMMATION 150 99.32 Very High Very High Very High
Overactive Bladder 6 99.08 Very High Very High Very High
Cognitive Disorder 1 98.92 Very High Very High Very High
Pain 75 98.80 Very High Very High Very High
Neurogenic Inflammation 14 98.44 Very High Very High Very High
Injury 36 97.88 Very High Very High Very High
Pancreatitis 9 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results of this study suggest that, while CP-96,345 binds to the NK-1 receptor in the spinal cord, this receptor is most likely not involved in mediating some types of nociception at the spinal cord level.
NK-1 receptor Binding (binds) of in spinal cord associated with nociception and spinal cord
1) Confidence 0.48 Published 1993 Journal Life Sci. Section Abstract Doc Link 7678436 Disease Relevance 0.21 Pain Relevance 0.80
Substance P (SP) binds to the NK-1 receptor and has been implicated in the transmission of pain as well as in physiological responses such as salivary gland secretion and neurogenic inflammation.
NK-1 receptor Binding (binds) of in salivary gland associated with pain, inflammation, neurogenic inflammation and substance p
2) Confidence 0.48 Published 1993 Journal Life Sci. Section Abstract Doc Link 7678436 Disease Relevance 0.31 Pain Relevance 0.57
The neurokinin-1 receptor and its tachykinin neuropeptide ligand substance P are associated with the mediation of nociception.
neurokinin-1 receptor Binding (associated) of associated with nociception, neuropeptide and substance p
3) Confidence 0.48 Published 1999 Journal Neuroscience Section Abstract Doc Link 10430499 Disease Relevance 0.32 Pain Relevance 0.37
Neurokinin-1 receptor binding decreased 5min after single and recurrent hypoxia and 2h after recurrent hypoxia, whereas mu-opioid binding remained unchanged.
Neurokinin-1 receptor Binding (binding) of associated with hypoxia and opioid
4) Confidence 0.48 Published 2003 Journal Brain Res. Bull. Section Abstract Doc Link 12464404 Disease Relevance 0.75 Pain Relevance 0.46
Neurokinin-1 versus mu-opioid receptor binding in rat nucleus tractus solitarius after single and recurrent intermittent hypoxia.
Neurokinin-1 Binding (binding) of in nucleus associated with hypoxia and opioid receptor
5) Confidence 0.48 Published 2003 Journal Brain Res. Bull. Section Title Doc Link 12464404 Disease Relevance 0.60 Pain Relevance 0.33
SP then binds to the neurokinin-1 receptor (NK1-R) on endothelial cells and promotes extravasation of plasma and proteins into the interstitial tissue and neutrophil infiltration, a process called neurogenic inflammation.
neurokinin-1 receptor Binding (binds) of in plasma associated with inflammation and neurogenic inflammation
6) Confidence 0.43 Published 2005 Journal Pancreas Section Abstract Doc Link 15782105 Disease Relevance 0.17 Pain Relevance 0.32
SP then binds to the neurokinin-1 receptor (NK1-R) on endothelial cells and promotes extravasation of plasma and proteins into the interstitial tissue and neutrophil infiltration, a process called neurogenic inflammation.
NK1-R Binding (binds) of in plasma associated with inflammation and neurogenic inflammation
7) Confidence 0.43 Published 2005 Journal Pancreas Section Abstract Doc Link 15782105 Disease Relevance 0.17 Pain Relevance 0.32
Inhibition of capsaicin-enhanced angiogenesis was incomplete, and this may indicate a contribution of other neuropeptides, in addition to substance P-NK1 receptor interactions, in capsaicin-enhanced angiogenesis.
P-NK1 receptor Binding (interactions) of associated with qutenza, neuropeptide and substance p
8) Confidence 0.40 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12660314 Disease Relevance 0.14 Pain Relevance 0.70
Spinal cord sections were examined for internalization of NK-1r, as an indicator of substance P release.
NK-1r Spec (examined) Binding (internalization) of in Spinal cord associated with substance p and spinal cord
9) Confidence 0.37 Published 2007 Journal Neuroscience Section Abstract Doc Link 17257769 Disease Relevance 0.48 Pain Relevance 0.62
Internalization of the NK-1r was observed in neurons of lamina I in the T13-L2 and L6-S2 regions of the spinal cord, as well as in sympathetic preganglionic neurons at the L1 level.
NK-1r Binding (Internalization) of in neurons associated with spinal cord
10) Confidence 0.37 Published 2007 Journal Neuroscience Section Abstract Doc Link 17257769 Disease Relevance 0.32 Pain Relevance 0.63
However, the potency of capsaicin to elicit NK1 receptor internalization in the same slices was one order of magnitude higher (EC(50)=0.37 microM) in lamina I, probably because NK1 receptors become saturated at relatively low concentrations of substance P.
NK1 receptor Binding (internalization) of in lamina associated with qutenza, substance p and potency
11) Confidence 0.37 Published 2003 Journal Neuroscience Section Abstract Doc Link 12699788 Disease Relevance 0 Pain Relevance 1.10
Although there is no tonic release of SP in short-term inflammatory pain, at 3 hr after carrageenan injection, SP is released in response to both noxious and non-noxious somatosensory stimulation with SPR internalization being observed in neurons located in both laminae I and III-IV.
SPR Binding (internalization) of in neurons associated with ipn and substance p
12) Confidence 0.37 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10460273 Disease Relevance 0.96 Pain Relevance 1.13
Tooth extraction-induced internalization of the substance P receptor in trigeminal nucleus and spinal cord neurons: imaging the neurochemistry of dental pain.
substance P Binding (internalization) of in nucleus associated with pain, imagery, spinal cord and substance p
13) Confidence 0.37 Published 2002 Journal Pain Section Title Doc Link 11790480 Disease Relevance 0.33 Pain Relevance 0.68
To better understand the neurons in the trigeminal complex and spinal cord that are activated following nociceptive stimuli to the orofacial complex, we examined substance P (SP) induced internalization of substance P receptors (SPR) in neurons following dental extraction in the rat.
substance P Spec (examined) Binding (internalization) of in neurons associated with nociception, substance p and spinal cord
14) Confidence 0.37 Published 2002 Journal Pain Section Abstract Doc Link 11790480 Disease Relevance 0.33 Pain Relevance 0.57
To better understand the neurons in the trigeminal complex and spinal cord that are activated following nociceptive stimuli to the orofacial complex, we examined substance P (SP) induced internalization of substance P receptors (SPR) in neurons following dental extraction in the rat.
SPR Spec (examined) Binding (internalization) of in neurons associated with nociception, substance p and spinal cord
15) Confidence 0.37 Published 2002 Journal Pain Section Abstract Doc Link 11790480 Disease Relevance 0.33 Pain Relevance 0.57
Internalization of the neurokinin 1 receptor in rat myenteric neurons.
neurokinin 1 receptor Binding (Internalization) of in neurons
16) Confidence 0.37 Published 1999 Journal Neuroscience Section Title Doc Link 10336084 Disease Relevance 0 Pain Relevance 0.21
SP administration reversed the CPS-mediated inhibitory effects on the total thymocyte number and subset distribution, namely CD4+ and CD4- CD8- cells, through its interaction with NK-1R as shown by concomitant NK-1R (SR140333) antagonist administration.
NK-1R Binding (interaction) of in thymocyte associated with qutenza, antagonist and substance p
17) Confidence 0.37 Published 2004 Journal Neuroimmunomodulation Section Abstract Doc Link 15067207 Disease Relevance 0.43 Pain Relevance 1.01
Herein we provide evidence that substance P (SP) and its neurokinin-1 receptor (NK-1R) expressed on thymocytes counteract thymus depletion induced by neonatal capsaicin (CPS) treatment by affecting thymocyte proliferation and apoptotic death.
neurokinin-1 receptor Binding (counteract) of in thymocyte associated with qutenza, apoptosis, death and substance p
18) Confidence 0.37 Published 2004 Journal Neuroimmunomodulation Section Abstract Doc Link 15067207 Disease Relevance 0.38 Pain Relevance 0.72
Herein we provide evidence that substance P (SP) and its neurokinin-1 receptor (NK-1R) expressed on thymocytes counteract thymus depletion induced by neonatal capsaicin (CPS) treatment by affecting thymocyte proliferation and apoptotic death.
NK-1R Binding (counteract) of in thymocyte associated with qutenza, apoptosis, death and substance p
19) Confidence 0.37 Published 2004 Journal Neuroimmunomodulation Section Abstract Doc Link 15067207 Disease Relevance 0.38 Pain Relevance 0.72
Inflammation increases the distribution of dorsal horn neurons that internalize the neurokinin-1 receptor in response to noxious and non-noxious stimulation.
neurokinin-1 receptor Binding (internalize) of in neurons associated with inflammation and dorsal horn neuron
20) Confidence 0.37 Published 1997 Journal J. Neurosci. Section Title Doc Link 9315923 Disease Relevance 0.39 Pain Relevance 0.63

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