INT49250

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Context Info
Confidence 0.08
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.54
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Atp6v0d2) transport (Atp6v0d2)
Anatomy Link Frequency
osteoclast 1
stalk 1
Atp6v0d2 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 3 100.00 Very High Very High Very High
Dopamine 5 99.96 Very High Very High Very High
Morphine 8 97.80 Very High Very High Very High
tolerance 5 97.44 Very High Very High Very High
agonist 41 97.12 Very High Very High Very High
addiction 5 96.88 Very High Very High Very High
cytokine 14 95.92 Very High Very High Very High
Antinociceptive 1 88.48 High High
tail-flick 2 86.32 High High
Arthritis 75 85.92 High High
Disease Link Frequency Relevance Heat
Hypercalcemia 17 98.96 Very High Very High Very High
Osteopetrosis 74 96.04 Very High Very High Very High
Pressure And Volume Under Development 18 87.80 High High
Arthritis 107 85.92 High High
Malignant Neoplastic Disease 4 85.28 High High
Morphine Dependence 2 83.64 Quite High
Disease 51 60.24 Quite High
INFLAMMATION 60 50.00 Quite Low
Obesity 1 40.56 Quite Low
Rheumatoid Arthritis 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Role of D1/D2 dopamine and N-methyl-D-aspartate (NMDA) receptors in morphine tolerance and dependence in mice.
Regulation (Role) of D1/D2 associated with addiction, dopamine, narcan, tolerance and morphine
1) Confidence 0.08 Published 1995 Journal Eur Neuropsychopharmacol Section Title Doc Link 7549459 Disease Relevance 0.14 Pain Relevance 1.54
In yeast cells, the RAVE complex mediates the reversible dissociation between the V1 and V0 complexes by binding to peripheral stalk subunits (C or E and G) [20,21], that is considered as one of the mechanisms controlling V-ATPase activity [20-22].
Regulation (controlling) of V-ATPase in stalk
2) Confidence 0.04 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2629482 Disease Relevance 0 Pain Relevance 0
The gene encoding for the Skp1 subunit of the RAVE complex is found in the E. histolytica genome (there are four gene sequences encoding for this subunit in Pathema: EHI_118670, EHI_174130, EHI_066770 and EHI_174180), suggesting a similar V-ATPase regulation mechanism in this parasite.
Regulation (regulation) of V-ATPase
3) Confidence 0.04 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2629482 Disease Relevance 0 Pain Relevance 0
Acid secretion is dependent on two key molecules, which facilitate proton transport: the proton pump vacuolar ATPase (V-ATPase) and the chloride-specific ion channel, chloride channel 7 (CLCN-7) [37].
Regulation (dependent) of V-ATPase
4) Confidence 0.04 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2654865 Disease Relevance 0.67 Pain Relevance 0
The apparent regulation of the TRAP, RANKL, ATPV0D2, and MMP9 expression after anti–MDL-1 treatment suggests MDL-1 receptor activation may promote osteoclast development and function.
Regulation (regulation) of ATPV0D2 in osteoclast
5) Confidence 0.01 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.34 Pain Relevance 0.21
Importantly, genes associated with bone destruction such as RANKL, MMP9, ATPV0D2, and TRAP are down-regulated in paws after MDL-1–Ig fusion treatment and up-regulated in anti–MDL-1 agonist treatment.
Regulation (regulated) of ATPV0D2 associated with agonist
6) Confidence 0.01 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.39 Pain Relevance 0.29

General Comments

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