INT49254

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Context Info
Confidence 0.69
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.42
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EDN1) extracellular region (EDN1) cell-cell signaling (EDN1)
cytoplasm (EDN1)
Anatomy Link Frequency
proximal 2
EDN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 4 99.52 Very High Very High Very High
Kinase C 3 97.84 Very High Very High Very High
anesthesia 4 97.20 Very High Very High Very High
cva 4 96.60 Very High Very High Very High
Catecholamine 1 85.44 High High
antagonist 70 83.60 Quite High
cytokine 3 80.72 Quite High
Analgesic 1 25.00 Low Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 4 99.52 Very High Very High Very High
Cv General 3 Under Development 4 96.60 Very High Very High Very High
Shock 2 94.80 High High
Hypoxia 10 94.08 High High
Cancer 65 93.48 High High
Stress 4 89.12 High High
Ovarian Cancer 23 86.72 High High
Targeted Disruption 1 73.04 Quite High
Natriuresis 3 61.36 Quite High
Pulmonary Hypertension 65 18.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To clarify the relationship between tissue ischemia and venous endothelin-1 (ET-1) level in humans, plasma ET-1 and oxygen content in the iliac vein were measured before anesthesia, after the induction of anesthesia, after the release of the proximal and first distal clamps, after the release of the second distal clamp, and 1 hour after the second clamping.
Transcription (level) of endothelin-1 in proximal associated with anesthesia and ischemia
1) Confidence 0.69 Published 1995 Journal J. Cardiothorac. Vasc. Anesth. Section Abstract Doc Link 8547550 Disease Relevance 0.44 Pain Relevance 0.37
To clarify the relationship between tissue ischemia and venous endothelin-1 (ET-1) level in humans, plasma ET-1 and oxygen content in the iliac vein were measured before anesthesia, after the induction of anesthesia, after the release of the proximal and first distal clamps, after the release of the second distal clamp, and 1 hour after the second clamping.
Transcription (level) of ET-1 in proximal associated with anesthesia and ischemia
2) Confidence 0.69 Published 1995 Journal J. Cardiothorac. Vasc. Anesth. Section Abstract Doc Link 8547550 Disease Relevance 0.44 Pain Relevance 0.37
This increase in big ET-1 release appeared to be partly due to a transient stimulation of the expression of prepro ET-1 mRNA.
Transcription (expression) of ET-1
3) Confidence 0.53 Published 1995 Journal Biol. Pharm. Bull. Section Abstract Doc Link 7550091 Disease Relevance 0 Pain Relevance 0
ET-1 release via a constitutive pathway is regulated principally at the level of gene transcription.
Transcription (transcription) of ET-1
4) Confidence 0.37 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.44 Pain Relevance 0.13
-mediated transcription of VEGF by ET-1 under normoxic conditions points to a general mechanism through which oncogenes and growth factors might upregulate VEGF, and could synergize with hypoxia during tumor growth.
Transcription (transcription) of ET-1 associated with cancer and hypoxia
5) Confidence 0.36 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 1.10 Pain Relevance 0.08

General Comments

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