INT49256

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 1995
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.50
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EDN1) extracellular region (EDN1) cell-cell signaling (EDN1)
cytoplasm (EDN1)
Anatomy Link Frequency
endothelial cells 4
EDN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 5 99.76 Very High Very High Very High
Calcium channel 9 99.52 Very High Very High Very High
ischemia 21 88.68 High High
cva 7 81.84 Quite High
Migraine 5 72.44 Quite High
Analgesic 2 25.00 Low Low
peripheral neuropathy 2 10.00 Low Low
Inflammation 6 5.00 Very Low Very Low Very Low
diabetic neuropathy 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 63 98.88 Very High Very High Very High
Scotoma 2 98.68 Very High Very High Very High
Vascular Disease 1 97.72 Very High Very High Very High
Increased Venous Pressure Under Development 112 97.20 Very High Very High Very High
Glaucoma 101 95.36 Very High Very High Very High
Amaurosis Fugax 1 89.84 High High
Syndrome 5 89.04 High High
Cv Unclassified Under Development 27 88.68 High High
Peripheral Arterial Disease 5 83.04 Quite High
Cv General 4 Under Development 3 82.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using cultured human aortic endothelial cells, we examined the effects of phosphoramidon, an endothelin converting enzyme (ECE) inhibitor, on the release of endogenous endothelin-1 (ET-1) and big endothelin-1 (big ET-1), and on the generation of ET-1 from exogenously applied big ET-1.
Spec (examined) Regulation (effects) of Positive_regulation (generation) of ET-1 in endothelial cells
1) Confidence 0.45 Published 1995 Journal Biol. Pharm. Bull. Section Abstract Doc Link 7550091 Disease Relevance 0 Pain Relevance 0
Using cultured human aortic endothelial cells, we examined the effects of phosphoramidon, an endothelin converting enzyme (ECE) inhibitor, on the release of endogenous endothelin-1 (ET-1) and big endothelin-1 (big ET-1), and on the generation of ET-1 from exogenously applied big ET-1.
Spec (examined) Regulation (effects) of Positive_regulation (generation) of ET-1 in endothelial cells
2) Confidence 0.45 Published 1995 Journal Biol. Pharm. Bull. Section Abstract Doc Link 7550091 Disease Relevance 0 Pain Relevance 0
Several studies show that calcium channel antagonists reduce the effect of increased levels of ET-1 on ocular perfusion and improve visual field defects through induced vasodilation (Flammer et al 2001).
Regulation (effect) of Positive_regulation (increased) of ET-1 associated with scotoma, antagonist, calcium channel and increased venous pressure under development
3) Confidence 0.43 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 1.52 Pain Relevance 0.61
The results suggest that ET-1, through activation of the ETA receptor, is of importance for the regulation of the microcirculation in diabetic patients with micro-angiopathy.
Regulation (regulation) of Positive_regulation (activation) of ET-1 associated with vascular disease and diabetes mellitus
4) Confidence 0.43 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605330 Disease Relevance 0.97 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox