INT49257

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Context Info
Confidence 0.46
First Reported 1995
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.10
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EDN1) extracellular region (EDN1) cell-cell signaling (EDN1)
cytoplasm (EDN1)
EDN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 29 83.60 Quite High
Analgesic 1 25.00 Low Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
nociceptor 2 5.00 Very Low Very Low Very Low
Pain refractory 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 9 94.08 High High
Cancer 65 93.48 High High
Ovarian Cancer 23 87.08 High High
Reprotox - General 1 16 5.00 Very Low Very Low Very Low
Apoptosis 16 5.00 Very Low Very Low Very Low
Skin Cancer 14 5.00 Very Low Very Low Very Low
Metastasis 13 5.00 Very Low Very Low Very Low
Sarcoma 9 5.00 Very Low Very Low Very Low
Breast Cancer 8 5.00 Very Low Very Low Very Low
Osteoporosis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This increase in big ET-1 release appeared to be partly due to a transient stimulation of the expression of prepro ET-1 mRNA.
Positive_regulation (stimulation) of Transcription (expression) of ET-1
1) Confidence 0.46 Published 1995 Journal Biol. Pharm. Bull. Section Abstract Doc Link 7550091 Disease Relevance 0 Pain Relevance 0
-mediated transcription of VEGF by ET-1 under normoxic conditions points to a general mechanism through which oncogenes and growth factors might upregulate VEGF, and could synergize with hypoxia during tumor growth.
Positive_regulation (mediated) of Transcription (transcription) of ET-1 associated with cancer and hypoxia
2) Confidence 0.27 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 1.10 Pain Relevance 0.08

General Comments

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