INT49263

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Context Info
Confidence 0.41
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 31
Total Number 38
Disease Relevance 9.86
Pain Relevance 16.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Grip2) plasma membrane (Grip2) cytoskeleton (Grip2)
cytoplasm (Grip2)
Anatomy Link Frequency
brain 4
hippocampus 4
amygdala 2
neurons 2
cerebral cortex 2
Grip2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 1442 100.00 Very High Very High Very High
antagonist 371 100.00 Very High Very High Very High
Gabapentin 53 100.00 Very High Very High Very High
Spinal cord 19 100.00 Very High Very High Very High
Morphine 15 100.00 Very High Very High Very High
amygdala 14 100.00 Very High Very High Very High
nociceptor 1 100.00 Very High Very High Very High
Neuropathic pain 6 99.84 Very High Very High Very High
Glutamate 491 99.64 Very High Very High Very High
Hippocampus 791 99.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aging 1254 99.92 Very High Very High Very High
Neuropathic Pain 7 99.84 Very High Very High Very High
Nervous System Injury 14 99.64 Very High Very High Very High
Sprains And Strains 77 99.26 Very High Very High Very High
Nociception 33 97.64 Very High Very High Very High
Pain 10 96.96 Very High Very High Very High
Opiate Addiction 2 96.28 Very High Very High Very High
Injury 22 95.00 High High
Hyperalgesia 18 94.40 High High
Drug Dependence 3 92.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Brain sections of 14-microm thickness were incubated with 15 nM [3H]AMPA for quantitation of binding to the AMPA receptor.
AMPA receptor Binding (binding) of in Brain
1) Confidence 0.41 Published 2000 Journal Brain Res. Bull. Section Abstract Doc Link 10822164 Disease Relevance 0.15 Pain Relevance 0.94
Desensitization of AMPA receptors limits the amplitude of EPSPs and the excitability of motoneurons of the rat isolated spinal cord.
AMPA Binding (Desensitization) of in motoneurons associated with spinal cord
2) Confidence 0.31 Published 1995 Journal Eur. J. Neurosci. Section Title Doc Link 7582096 Disease Relevance 0.07 Pain Relevance 0.21
To better examine glutamatergic involvement, an autoradiographic study of [3H]AMPA receptor binding and an assessment of in situ hybridization of AMPA sensitive glutamate receptor A (GluR-A) subunits in the rat brain were each performed 7 h after withdrawal from morphine infusion.
AMPA receptor Binding (binding) of in brain associated with glutamate receptor, withdrawal and morphine
3) Confidence 0.27 Published 2000 Journal Brain Res. Bull. Section Abstract Doc Link 10822164 Disease Relevance 0.19 Pain Relevance 0.74
These studies suggest a critical involvement of protein:protein complexes associated with the AMPA receptor in neuropathic pain, and the possibility that they may have potential as novel therapeutic targets.
AMPA receptor Binding (associated) of associated with neuropathic pain
4) Confidence 0.24 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 14550765 Disease Relevance 0.64 Pain Relevance 0.57
As a result, the specific binding of (S)-[3H]-5-fluorowillardiine to AMPA receptors in the cerebral cortex decreased 46% from 2.7 +/- 0.3 to 1.5 +/- 0.6 (density units).
AMPA Binding (binding) of in cerebral cortex associated with cerebral cortex
5) Confidence 0.20 Published 2004 Journal Neurochem. Res. Section Abstract Doc Link 15202775 Disease Relevance 0 Pain Relevance 0.39
However, there has been little data regarding the interaction between gabapentin and antagonists for NMDA or AMPA receptors at the spinal level in the formalin test, which is a preclinical pain model showing acute nociception followed by injury-induced hyperalgesia.
AMPA Binding (interaction) of in spinal associated with nociception, pain, hyperalgesia, antagonist, injury and gabapentin
6) Confidence 0.16 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808611 Disease Relevance 1.53 Pain Relevance 1.95
Interaction among NMDA receptor-, NMDA glycine site- and AMPA receptor antagonists in spinally mediated analgesia.
AMPA receptor Binding (Interaction) of associated with nociceptor, antagonist, nmda receptor and analgesia
7) Confidence 0.14 Published 2000 Journal Can J Anaesth Section Title Doc Link 10930211 Disease Relevance 0.09 Pain Relevance 0.48
The in vitro potency of these QXs was determined by inhibition of [3H]-5,7-dichlorokynurenic acid ([3H]DCKA) binding to N-methyl-D-aspartate (NMDA)/glycine receptors, [3H]-(S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ([3H]AMPA) binding to AMPA receptors, and [3H]kainate ([3H]KA) binding to KA receptors in rat brain membranes. 5-(N-Oxyaza)-QXs 12a-e all have low micromolar or submicromolar potency for NMDA/glycine receptors and low micromolar potencies for AMPA and KA receptors.
AMPA Binding (binding) of in brain associated with potency
8) Confidence 0.12 Published 1997 Journal J. Med. Chem. Section Abstract Doc Link 9357535 Disease Relevance 0 Pain Relevance 0.31
The authors hypothesized that the interaction between morphine and AMPA receptor antagonists would be synergistic, whereas morphine and NMDA antagonists show no such interaction in acute nociception.
AMPA Binding (interaction) of associated with nociception, antagonist and morphine
9) Confidence 0.11 Published 1998 Journal Anesthesiology Section Abstract Doc Link 9743410 Disease Relevance 0.36 Pain Relevance 0.73
Further, retrieval of recent affective memory engages amygdala AMPA receptors, whereas retrieval of remote affective memory engages AMPA receptors in the medial prefrontal cortex.
AMPA Binding (engages) of in amygdala associated with amygdala
10) Confidence 0.11 Published 1996 Journal Chin J Physiol Section Abstract Doc Link 8955562 Disease Relevance 0 Pain Relevance 0.35
Further, retrieval of recent affective memory engages amygdala AMPA receptors, whereas retrieval of remote affective memory engages AMPA receptors in the medial prefrontal cortex.
AMPA Binding (engages) of in amygdala associated with amygdala
11) Confidence 0.11 Published 1996 Journal Chin J Physiol Section Abstract Doc Link 8955562 Disease Relevance 0 Pain Relevance 0.34
Present experiments were carried out to analyse the interactions between AMPA and serotoninergic receptors in the control of prolactin secretion in prepubertal male rats.
AMPA Spec (analyse) Binding (interactions) of
12) Confidence 0.11 Published 2001 Journal J. Physiol. Biochem. Section Abstract Doc Link 11800286 Disease Relevance 0 Pain Relevance 0.44
We conclude that input from granule cells and the perforant path results in activation of basket cells via glutamatergic synapses that employ both NMDA and AMPA receptors.
AMPA Binding (employ) of in granule cells
13) Confidence 0.11 Published 1995 Journal Hippocampus Section Abstract Doc Link 7550611 Disease Relevance 0 Pain Relevance 0.29
We propose that domoate binding to AMPA receptors opens channels mediating ionic influx, presumably Na+ followed passively by Cl-.
AMPA Binding (binding) of
14) Confidence 0.10 Published 1996 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8909784 Disease Relevance 0.25 Pain Relevance 0.36
These results suggest that: (1) AMPA receptor-expressing neurons appear to be the exclusive recipient of hypothalamic Leu-enkephalin boutons; (2) these enkephalinoceptive neurons contain both GluR1 and GluR2/3 AMPA receptor subunits; however, (3) only the GluR2/3 subtype, located in the perisomatic area, may be associated with Leu-enkephalin-containing inputs.
AMPA Binding (contain) of in neurons associated with enkephalin
15) Confidence 0.10 Published 1997 Journal Synapse Section Abstract Doc Link 9068124 Disease Relevance 0 Pain Relevance 0.44
Thus, the results indicate that there are stimulatory presynaptic NMDA and AMPA receptors on noradrenergic axon terminals in the spinal cord and that they interact synergistically to evoke release of [3H]NA.
AMPA Binding (interact) of in spinal cord associated with noradrenaline and spinal cord
16) Confidence 0.09 Published 1998 Journal Neurochem. Res. Section Abstract Doc Link 9821153 Disease Relevance 0 Pain Relevance 0.63
Further, the effect of combinations of NMDA and AMPA receptor antagonists on halothane MAC is consistent with an in vivo physiologic interaction between the NMDA and AMPA receptors.
AMPA Binding (interaction) of associated with antagonist and halothane
17) Confidence 0.09 Published 1995 Journal Neuropharmacology Section Abstract Doc Link 7566502 Disease Relevance 0 Pain Relevance 0.81
The particular EGFP-fusion protein used here was characterized extensively [35],[44]; When expressed in cultured hippocampal neurons, it was shown to localize correctly to postsynaptic structures associated with functional presynaptic sites, colocalize with the AMPA receptor subunit GluR1, and only negligibly affect gross synaptic characteristics [35].
AMPA receptor Binding (colocalize) of in neurons
18) Confidence 0.02 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2693930 Disease Relevance 0 Pain Relevance 0.03
Most notably, we have reported an increase in AMPA receptor autoradiographic binding at post-nerve injury survival durations when the putative second phase of reorganization has been completed (Garraghty et al., 2006), but this was not seen at early (i.e., 0–3?
AMPA receptor Binding (binding) of in nerve associated with nervous system injury
19) Confidence 0.01 Published 2008 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2638550 Disease Relevance 0.32 Pain Relevance 0.29
After reaching the cell surface, AMPA-Rs interact with a variety of scaffold proteins that facilitate synaptic localization of the receptors [90, 149, 150].
AMPA Binding (interact) of
20) Confidence 0.01 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.04

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