INT49266

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Context Info
Confidence 0.47
First Reported 1995
Last Reported 2011
Negated 4
Speculated 1
Reported most in Abstract
Documents 37
Total Number 56
Disease Relevance 53.79
Pain Relevance 11.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma cells 3
pancreas 3
pancreatic duct 2
bowel 1
eggs 1
Arigg4 (Mus musculus)
Pain Link Frequency Relevance Heat
spastic colon 15 100.00 Very High Very High Very High
abdominal pain 161 99.90 Very High Very High Very High
imagery 450 99.52 Very High Very High Very High
Chronic pancreatitis 220 99.16 Very High Very High Very High
fibrosis 262 98.80 Very High Very High Very High
Inflammation 189 98.60 Very High Very High Very High
Bile 112 98.32 Very High Very High Very High
backache 3 97.08 Very High Very High Very High
corticosteroid 501 95.28 Very High Very High Very High
Pain 45 94.80 High High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

19 100.00 Very High Very High Very High
Disease 701 99.96 Very High Very High Very High
Hypergammaglobulinemia 5 99.96 Very High Very High Very High
Pancreatitis 2779 99.90 Very High Very High Very High
Abdominal Pain 161 99.90 Very High Very High Very High
Sclerosis 22 99.88 Very High Very High Very High
Carcinoma 2 99.88 Very High Very High Very High
Food Hypersensitivity 6 99.84 Very High Very High Very High
Calcification 57 99.42 Very High Very High Very High
Pancreatic Cancer 35 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated serum IgG4 levels have been described in patients with LPSP and have been used to distinguish LPSP from pancreatic carcinoma preoperatively.
Positive_regulation (Elevated) of IgG4 associated with pancreatic cancer and pancreatitis
1) Confidence 0.47 Published 2004 Journal Semin Diagn Pathol Section Abstract Doc Link 16273942 Disease Relevance 1.57 Pain Relevance 0.33
Determination of elevated IgG4 levels in children with pancreatic head masses may allow for the medical treatment of LPSP.
Positive_regulation (elevated) of IgG4 in head associated with pancreatitis
2) Confidence 0.47 Published 2006 Journal J. Pediatr. Surg. Section Abstract Doc Link 16677871 Disease Relevance 0.90 Pain Relevance 0.20
Patients, who are usually over 40 years of age, show 1) mild unspecific abdominal pain, 2) increased serum immunoglobulins (specifically IgG4) and autoantibodies, and 3) diffuse or focal enlargement of the pancreas with pancreatic strictures and sometimes jaundice due to biliary obstruction (detectable by US, CT, MRI, ERCP and/or endoscopic ultrasound (EUS)).
Positive_regulation (increased) of IgG4 in pancreas associated with abdominal pain and jaundice
3) Confidence 0.47 Published 2008 Journal Praxis Section Abstract Doc Link 18549013 Disease Relevance 0.62 Pain Relevance 0.19
Therefore, we have begun screening for elevated serum IgG4 concentrations to identify patients with possible autoimmune pancreatitis who present without definitive pathological or radiographic evidence for malignancy.
Positive_regulation (elevated) of IgG4
4) Confidence 0.34 Published 2005 Journal JOP Section Body Doc Link 16186668 Disease Relevance 0.06 Pain Relevance 0
Laboratory testing revealed a normal CA19-9 (33 U/mL) and an elevated IgG4 (133 mg/dL).
Positive_regulation (elevated) of IgG4
5) Confidence 0.31 Published 2008 Journal Am Surg Section Abstract Doc Link 18646484 Disease Relevance 1.07 Pain Relevance 0.22
IgG4 antibodies to common food antigens are elevated in IBS.
Positive_regulation (elevated) of IgG4 associated with spastic colon
6) Confidence 0.17 Published 2005 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 16109655 Disease Relevance 0.17 Pain Relevance 0.46
RESULTS: IgG4 antibodies to milk, eggs, wheat, beef, pork and lamb were commonly elevated.
Positive_regulation (elevated) of IgG4 in eggs
7) Confidence 0.11 Published 2005 Journal Scand. J. Gastroenterol. Section Body Doc Link 16109655 Disease Relevance 0 Pain Relevance 0
Elevated serum amylase, typical radiographic findings and selective increase in serum IgG4 all suggested that the patient also had autoimmune pancreatitis.
Positive_regulation (increase) of IgG4 associated with pancreatitis
8) Confidence 0.11 Published 2007 Journal Lupus Section Abstract Doc Link 17402370 Disease Relevance 1.70 Pain Relevance 0.09
As demonstrated, the diagnosis should not be based solely on the elevation of IgG4 or autoantibodies.
Positive_regulation (elevation) of IgG4
9) Confidence 0.03 Published 2007 Journal Z Gastroenterol Section Abstract Doc Link 18080226 Disease Relevance 1.01 Pain Relevance 0.12
OBJECTIVES: Serum immunoglobulin G (IgG) and/or IgG4 elevation is one of the notable characteristics of autoimmune chronic pancreatitis (AIP).
Positive_regulation (elevation) of IgG4 associated with chronic pancreatitis
10) Confidence 0.03 Published 2007 Journal Pancreas Section Abstract Doc Link 17632322 Disease Relevance 0.27 Pain Relevance 0.36
In contrast, no patient showed elevated IgG4, or antibodies for carboanhydrase-II, for lactoferrin, or rheumatoid factor, serum markers reported to be positive in autoimmune pancreatitis.
Positive_regulation (elevated) of IgG4 associated with pancreatitis
11) Confidence 0.03 Published 2007 Journal Z Gastroenterol Section Abstract Doc Link 18080226 Disease Relevance 1.14 Pain Relevance 0.17
The serum IgG and IgG4 levels were increased on serological examination.
Spec (examination) Positive_regulation (increased) of IgG4
12) Confidence 0.03 Published 2007 Journal JOP Section Body Doc Link 17873471 Disease Relevance 0.07 Pain Relevance 0
Hypergammaglobulinemia, increased serum levels of total IgG or IgG4, positive antilactoferrin and anti carbonic anhydrase II autoantibodies are quite frequently found in autoimmune pancreatitis.
Positive_regulation (increased) of IgG4 associated with hypergammaglobulinemia and pancreatitis
13) Confidence 0.03 Published 2006 Journal Rom J Intern Med Section Abstract Doc Link 17236284 Disease Relevance 0.54 Pain Relevance 0.17
No increased IgG4 plasma cells were found in any of 103 controls (100% specificity).
Neg (No) Positive_regulation (increased) of IgG4 in plasma cells
14) Confidence 0.02 Published 2009 Journal Mod. Pathol. Section Abstract Doc Link 19136927 Disease Relevance 1.02 Pain Relevance 0.31
Elevated serum IgG4 levels are characteristic and may be very helpful in the differential diagnosis from tumors and tumor-like lesions of the pancreas which seldom result in levels above 135 mg/dL.
Positive_regulation (Elevated) of IgG4 in pancreas associated with cancer
15) Confidence 0.02 Published 2005 Journal Semin Diagn Pathol Section Abstract Doc Link 16939059 Disease Relevance 1.28 Pain Relevance 0.25
In addition to elevated serum IgG4 levels, IgG4 immunostaining of involved tissue is often used to support the diagnosis of AIP.
Positive_regulation (elevated) of IgG4 associated with pancreatitis
16) Confidence 0.02 Published 2010 Journal Dig Surg Section Abstract Doc Link 20551653 Disease Relevance 0.66 Pain Relevance 0.09
10 cells/hpf) IgG4-positive cells]; Imaging, typically diffusely enlarged gland with delayed (rim) enhancement, diffusely irregular, attenuated main pancreatic duct or alternatively, focal pancreatic mass/enlargement, focal pancreatic duct stricture, pancreatic atrophy, pancreatic calcification, or pancreatitis; Serology, elevated serum IgG4 level (>140 mg/dL); Other organ involvement, hilar/intrahepatic biliary strictures, persistent distal biliary stricture, parotid/lacrimal gland involvement, mediastinal lymphadenopathy, retroperitoneal fibrosis; and response to steroid therapy, resolution/marked improvement of pancreatic/extrapancreatic manifestations with steroid therapy [3,5].
Positive_regulation (elevated) of IgG4 in lacrimal gland associated with disorders of the lacrimal system, lymphadenopathy, pancreatitis, fibrosis, calcification, retroperitoneal fibrosis, frailty and imagery
17) Confidence 0.02 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 1.46 Pain Relevance 0.28
In addition to the imaging and histologic characteristics of AIP, a sensitive and specific serologic association with elevated IgG4 serum levels was first described by Hamano et al. [6].
Positive_regulation (elevated) of IgG4 associated with pancreatitis and imagery
18) Confidence 0.02 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 1.52 Pain Relevance 0.38
Since then there have been many reports of adults with isolated AIP and multisystem sclerosis with elevated IgG4 levels [7].
Positive_regulation (elevated) of IgG4 associated with sclerosis and pancreatitis
19) Confidence 0.02 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 1.33 Pain Relevance 0.16
A computerized tomography (CT) scan revealed multiple pancreatic masses and biliary dilatation, lab work revealed an elevated IgG4, and she was transferred to our institution for further work up and management.
Positive_regulation (elevated) of IgG4
20) Confidence 0.02 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 1.28 Pain Relevance 0.32

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