INT4929

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Context Info
Confidence 0.48
First Reported 1985
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 25
Total Number 29
Disease Relevance 18.01
Pain Relevance 9.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mbp)
Anatomy Link Frequency
B cell 4
optic 3
T cells 3
cerebrospinal fluid 2
blood 2
Mbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 77 99.92 Very High Very High Very High
Multiple sclerosis 63 99.90 Very High Very High Very High
substance P 2 99.80 Very High Very High Very High
imagery 64 99.72 Very High Very High Very High
Hippocampus 2 98.40 Very High Very High Very High
unmyelinated 1 98.12 Very High Very High Very High
Demyelination 9 95.44 Very High Very High Very High
Taxol 150 92.08 High High
Spinal cord 17 86.48 High High
tetrodotoxin 1 85.84 High High
Disease Link Frequency Relevance Heat
Cancer 23 100.00 Very High Very High Very High
Immunization 7 100.00 Very High Very High Very High
Optic Neuritis 69 99.92 Very High Very High Very High
Demyelinating Disease 73 99.90 Very High Very High Very High
Coronary Artery Disease 7 99.84 Very High Very High Very High
Disease 15 99.76 Very High Very High Very High
Multiple Sclerosis 19 99.74 Very High Very High Very High
Experimental Autoimmune Encephalomyelitis 7 99.64 Very High Very High Very High
Rhinitis 2 99.42 Very High Very High Very High
Neuropathic Pain 29 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MBP from HBO(2) treated CO-exposed rats is recognized normally by a battery of antibodies, but exhibits an abnormal charge pattern.
MBP Binding (recognized) of
1) Confidence 0.48 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 16325878 Disease Relevance 0.42 Pain Relevance 0.07
Pronounced differences in occurrence and numbers of T cells recognizing MBP, MBP peptides with the amino acid sequences 63-88, 110-128 and 148-165, and PLP were noticed in individual ON and MS patients over the course of disease.
MBP Binding (recognizing) of in T cells associated with multiple sclerosis, disease and neuritis
2) Confidence 0.47 Published 1994 Journal Acta Neurol. Scand. Section Abstract Doc Link 7524258 Disease Relevance 1.40 Pain Relevance 0.97
These data suggest that acute idiopathic optic neuritis, like active MS, is associated with anti-MBP.
anti-MBP Binding (associated) of in optic associated with multiple sclerosis, optic neuritis and neuritis
3) Confidence 0.41 Published 1988 Journal Ann. Neurol. Section Abstract Doc Link 2454070 Disease Relevance 0.81 Pain Relevance 0.53
Histological and electrophysiological studies were performed on Lewis rats with acute experimental allergic encephalomyelitis (EAE) induced by inoculation with guinea-pig myelin basic protein (MBP) and Freund's adjuvant.
myelin basic protein Binding (inoculation) of associated with multiple sclerosis and experimental autoimmune encephalomyelitis
4) Confidence 0.37 Published 1988 Journal J. Neurol. Sci. Section Abstract Doc Link 2464669 Disease Relevance 0.43 Pain Relevance 0.21
Histological and electrophysiological studies were performed on Lewis rats with acute experimental allergic encephalomyelitis (EAE) induced by inoculation with guinea-pig myelin basic protein (MBP) and Freund's adjuvant.
MBP Binding (inoculation) of associated with multiple sclerosis and experimental autoimmune encephalomyelitis
5) Confidence 0.37 Published 1988 Journal J. Neurol. Sci. Section Abstract Doc Link 2464669 Disease Relevance 0.43 Pain Relevance 0.21
Immunoreactive myelin basic protein in tumor cells associated with carcinomatous neuropathy.
myelin basic protein Binding (associated) of associated with cancer and neuropathic pain
6) Confidence 0.37 Published 1985 Journal Am. J. Clin. Pathol. Section Title Doc Link 2416217 Disease Relevance 0.79 Pain Relevance 0.08
The MBP peptide among those three included, that was predominantly recognized by T cells in the individual patient, also varied over the course.
MBP Binding (recognized) of in T cells
7) Confidence 0.36 Published 1994 Journal Acta Neurol. Scand. Section Abstract Doc Link 7524258 Disease Relevance 1.37 Pain Relevance 0.96
Pronounced differences in occurrence and numbers of T cells recognizing MBP, MBP peptides with the amino acid sequences 63-88, 110-128 and 148-165, and PLP were noticed in individual ON and MS patients over the course of disease.
MBP Binding (recognizing) of in T cells associated with multiple sclerosis, disease and neuritis
8) Confidence 0.36 Published 1994 Journal Acta Neurol. Scand. Section Abstract Doc Link 7524258 Disease Relevance 1.40 Pain Relevance 0.97
Having studied astrocyte/T-cell interactions in more detail, we discovered that encephalitogenic T-cell lines recognizing MBP on astrocytes will subsequently proceed to kill the presenting cells.
MBP Binding (recognizing) of in astrocytes
9) Confidence 0.36 Published 1986 Journal Nature Section Abstract Doc Link 2419764 Disease Relevance 0.24 Pain Relevance 0.06
In addition to VEP and MRI studies, the CSF MBP and serum anti-myelin antibody can be useful in the diagnosis and follow-up the patients with optic neuritis.
CSF MBP Binding (useful) of in optic associated with optic neuritis, neuritis and imagery
10) Confidence 0.35 Published 1990 Journal Brain Dev. Section Abstract Doc Link 2092591 Disease Relevance 0.90 Pain Relevance 0.74
Oral tolerization with acetylcholine receptor (AChR) and myelin basic protein (MBP) prior to immunization with AChR+MBP+ complete Freund's adjuvant (CFA) alleviated clinical signs of experimental autoimmune myasthenia gravis (EAMG)+experimental allergic encephalomyelitis (EAE) and AChR- or MBP-specific T and B cell responses.
MBP Binding (tolerization) of in B cell associated with multiple sclerosis, immunization, experimental autoimmune myasthenia gravis and experimental autoimmune encephalomyelitis
11) Confidence 0.34 Published 1998 Journal J. Neurol. Sci. Section Abstract Doc Link 9562316 Disease Relevance 0.87 Pain Relevance 0.21
Oral tolerization with acetylcholine receptor (AChR) and myelin basic protein (MBP) prior to immunization with AChR+MBP+ complete Freund's adjuvant (CFA) alleviated clinical signs of experimental autoimmune myasthenia gravis (EAMG)+experimental allergic encephalomyelitis (EAE) and AChR- or MBP-specific T and B cell responses.
MBP Binding (immunization) of in B cell associated with multiple sclerosis, immunization, experimental autoimmune myasthenia gravis and experimental autoimmune encephalomyelitis
12) Confidence 0.34 Published 1998 Journal J. Neurol. Sci. Section Abstract Doc Link 9562316 Disease Relevance 0.88 Pain Relevance 0.21
Oral tolerization with acetylcholine receptor (AChR) and myelin basic protein (MBP) prior to immunization with AChR+MBP+ complete Freund's adjuvant (CFA) alleviated clinical signs of experimental autoimmune myasthenia gravis (EAMG)+experimental allergic encephalomyelitis (EAE) and AChR- or MBP-specific T and B cell responses.
myelin basic protein Binding (tolerization) of in B cell associated with multiple sclerosis, immunization, experimental autoimmune myasthenia gravis and experimental autoimmune encephalomyelitis
13) Confidence 0.34 Published 1998 Journal J. Neurol. Sci. Section Abstract Doc Link 9562316 Disease Relevance 0.87 Pain Relevance 0.20
T cells recognizing multiple peptides of myelin basic protein are found in blood and enriched in cerebrospinal fluid in optic neuritis and multiple sclerosis.
myelin basic protein Binding (recognizing) of in blood associated with multiple sclerosis, optic neuritis and neuritis
14) Confidence 0.33 Published 1993 Journal Scand. J. Immunol. Section Title Doc Link 7680141 Disease Relevance 1.02 Pain Relevance 0.62
The mean blood pressure (MBP) before coronary ligation was significantly lower in U-anesthetized animals (72 +/- 3.5 vs. 102 +/- 4.1 and 108 +/- 5.9 mm Hg in P and D+K, respectively).
MBP Binding (ligation) of in blood
15) Confidence 0.31 Published 1997 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9057068 Disease Relevance 0.81 Pain Relevance 0.32
Free and bound levels of anti-myelin basic protein (anti-MBP) antibodies were measured by radioimmunoassay in the cerebrospinal fluid of 20 patients with acute idiopathic optic neuritis, 133 patients with multiple sclerosis (MS) divided into three clinical subgroups, and 76 normal control subjects.
anti-MBP Binding (bound) of in cerebrospinal fluid associated with multiple sclerosis, optic neuritis and neuritis
16) Confidence 0.31 Published 1988 Journal Ann. Neurol. Section Abstract Doc Link 2454070 Disease Relevance 0.57 Pain Relevance 0.46
Free and bound levels of anti-myelin basic protein (anti-MBP) antibodies were measured by radioimmunoassay in the cerebrospinal fluid of 20 patients with acute idiopathic optic neuritis, 133 patients with multiple sclerosis (MS) divided into three clinical subgroups, and 76 normal control subjects.
anti-myelin basic protein Binding (bound) of in cerebrospinal fluid associated with multiple sclerosis, optic neuritis and neuritis
17) Confidence 0.31 Published 1988 Journal Ann. Neurol. Section Abstract Doc Link 2454070 Disease Relevance 0.56 Pain Relevance 0.46
Monosymptomatic unilateral optic neuritis (ON) is a common first manifestation of multiple sclerosis (MS) in which increased numbers of autoimmune T and B cells, recognizing different myelin autoantigens including myelin basic protein (MBP) and its peptides, have been implicated in a hypothetical immunopathogenesis.
MBP Binding (recognizing) of in B cells associated with multiple sclerosis, optic neuritis and neuritis
18) Confidence 0.29 Published 1993 Journal Neurology Section Abstract Doc Link 7513391 Disease Relevance 0.69 Pain Relevance 0.52
Using a phosphospecific antibody that recognizes the predominant MAPK phosphorylation site in MBP, Thr95, we found that MBP phosphorylation is regulated by high-frequency stimulation but not low-frequency stimulation of the alveus.
MBP Binding (recognizes) of
19) Confidence 0.27 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10461899 Disease Relevance 0.18 Pain Relevance 0.30
Optic neuritis is associated with myelin basic protein and proteolipid protein reactive cells producing interferon-gamma, interleukin-4 and transforming growth factor-beta.
myelin basic protein Binding (associated) of in Optic associated with optic neuritis and neuritis
20) Confidence 0.14 Published 1994 Journal J. Neuroimmunol. Section Title Doc Link 7507500 Disease Relevance 0.75 Pain Relevance 0.70

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