INT49292

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Context Info
Confidence 0.69
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 6.16
Pain Relevance 4.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp1a2) endoplasmic reticulum (Cyp1a2) enzyme binding (Cyp1a2)
Anatomy Link Frequency
platelet 2
plasma 1
liver 1
urine 1
Cyp1a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 57 100.00 Very High Very High Very High
Nicotine 3 99.28 Very High Very High Very High
Chronic pancreatitis 4 76.80 Quite High
Glutamate 1 74.96 Quite High
alcohol 1 74.08 Quite High
Bioavailability 2 71.84 Quite High
Migraine 2 66.28 Quite High
headache 7 62.32 Quite High
beta blocker 3 62.08 Quite High
antagonist 6 59.80 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 193 99.98 Very High Very High Very High
Cataract 6 99.18 Very High Very High Very High
Emergencies 9 98.86 Very High Very High Very High
Hepatotoxicity 16 97.72 Very High Very High Very High
Stress 5 93.28 High High
Myocardial Infarction 81 84.32 Quite High
Diabetes Mellitus 18 80.24 Quite High
Toxicity 4 75.00 Quite High
Pancreatitis 4 75.00 Quite High
Liver Disease 1 71.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further examination of both CYP1A isoforms revealed that hepatic CYP1A1 and CYP1A2 mRNA and protein levels were significantly elevated in animals from the susceptible group.
Positive_regulation (elevated) of CYP1A2
1) Confidence 0.69 Published 1997 Journal Pharmacogenetics Section Abstract Doc Link 9295056 Disease Relevance 0.20 Pain Relevance 0.51
Immunoblot analysis of microsomal proteins showed that rutaecarpine-treatment increased the protein levels of CYP1A1 and CYP1A2 in the liver, whereas hepatic level of CYP3A-immunoreacted protein was not affected by rutaecarpine.
Positive_regulation (increased) of CYP1A2 in liver
2) Confidence 0.67 Published 2001 Journal Life Sci. Section Abstract Doc Link 11787945 Disease Relevance 0.12 Pain Relevance 0.06
Immunoblot analyses showed that methanol extract increased the levels of CYP1A1, CYP1A2, CYP2B-, and GSTYb-immunoreactive proteins.
Positive_regulation (increased) of CYP1A2
3) Confidence 0.63 Published 2002 Journal Life Sci. Section Abstract Doc Link 12106592 Disease Relevance 0.12 Pain Relevance 0.06
Aqueous extract increased CYP1A2 protein level.
Positive_regulation (increased) of CYP1A2
4) Confidence 0.63 Published 2002 Journal Life Sci. Section Abstract Doc Link 12106592 Disease Relevance 0.11 Pain Relevance 0.05
The effect of acetaminophen (APAP) dose on the cytochrome P450s responsible for its bioactivation was examined in control mice and mice treated with acetone to induce CYP2E1, or beta-napthaflavone to induce CYP1A2.
Positive_regulation (induce) of CYP1A2 associated with paracetamol
5) Confidence 0.49 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8074700 Disease Relevance 0.17 Pain Relevance 0.77
The co-segregation of elevated basal Cyp1a1 and CYP1a2 gene expression levels in animals selected for susceptibility to acetaminophen-induced hepatotoxicity suggested a common heritable basis for regulation of basal expression of both of these CYP1A isoforms.
Positive_regulation (elevated) of CYP1a2 associated with paracetamol and hepatotoxicity
6) Confidence 0.46 Published 1997 Journal Pharmacogenetics Section Abstract Doc Link 9295056 Disease Relevance 0.17 Pain Relevance 0.39
Among the four component herbs of Wu-chu-yu-tang, only Evodiae Fructus (Wu-chu-yu) extract increased EROD activity and CYP1a2 protein level.
Positive_regulation (increased) of CYP1a2
7) Confidence 0.45 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 12184732 Disease Relevance 0.13 Pain Relevance 0.07
These results demonstrated that ingestion of Wu-chu-yu-tang elevated mouse hepatic Cyp1a2 activity and protein level.
Positive_regulation (elevated) of Cyp1a2
8) Confidence 0.45 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 12184732 Disease Relevance 0.10 Pain Relevance 0.05
Acetaminophen produces cataract in DBA2 mice by Ah receptor-independent induction of CYP1A2.
Neg (independent) Positive_regulation (induction) of CYP1A2 associated with paracetamol and cataract
9) Confidence 0.45 Published 2000 Journal J Ocul Pharmacol Ther Section Title Doc Link 10977129 Disease Relevance 0.40 Pain Relevance 0.50
Analysis of phase I detoxification genes revealed that CYP1A2 and CYP3A11 were up-regulated in wild-type mice but down-regulated in RXRalpha-deficient mice after APAP administration.
Positive_regulation (up-regulated) of CYP1A2 associated with paracetamol
10) Confidence 0.43 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 14978233 Disease Relevance 0.27 Pain Relevance 0.39
Lower basal Cyp1a2 mRNA levels and lower expression of Cyp1a2 and Cyp3a11 mRNAs after APAP dosing were also observed in females compared with males.
Positive_regulation (observed) of Cyp1a2 associated with paracetamol
11) Confidence 0.41 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16611625 Disease Relevance 0.44 Pain Relevance 1.13
The polymorphism of this subtype can induce loss-of-function to a considerable extent.25)26) Because CYP1A2 affects only the first oxidative step of clopidogrel, induction of CYP1A2 by smoking may have a relatively weak impact on clopidogrel activation.25)26) Furthermore, we assessed residual platelet reactivity at least 3 days after emergency stenting, which may be related to a decrease in smoking-induced CYP1A2 activity.
Positive_regulation (induction) of CYP1A2 in platelet associated with emergencies and nicotine addiction
12) Confidence 0.29 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2844977 Disease Relevance 1.07 Pain Relevance 0
Ethoxyresorufin O-deethylase activity, associated with both CYP1A1 and CYP1A2, was also significantly elevated in this group.
Positive_regulation (elevated) of CYP1A2
13) Confidence 0.20 Published 1997 Journal Pharmacogenetics Section Abstract Doc Link 9295056 Disease Relevance 0.19 Pain Relevance 0.51
Of these, CYP isoenzyme 1A2 is activated by the polycyclic aromatic hydrocarbons in cigarette smoke and induced by plasma nicotine.6)12) Therefore, cigarette smoking induces CYP1A2 activity and contributes to the increased metabolite of clopidogrel in a dose-related manner.13) Interestingly, some reports suggested that smoking might have a good effect on short-term clinical outcomes after coronary stenting.14)15)
Positive_regulation (induces) of CYP1A2 in plasma associated with nicotine addiction and nicotine
14) Confidence 0.19 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2844977 Disease Relevance 1.12 Pain Relevance 0.11
The polymorphism of this subtype can induce loss-of-function to a considerable extent.25)26) Because CYP1A2 affects only the first oxidative step of clopidogrel, induction of CYP1A2 by smoking may have a relatively weak impact on clopidogrel activation.25)26) Furthermore, we assessed residual platelet reactivity at least 3 days after emergency stenting, which may be related to a decrease in smoking-induced CYP1A2 activity.
Positive_regulation (induced) of CYP1A2 in platelet associated with emergencies and nicotine addiction
15) Confidence 0.19 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2844977 Disease Relevance 0.95 Pain Relevance 0
Also, CYP1A2 can be induced by smoking and other drugs.84 Irrespective of the dosage, the terminal elimination half-life of ropinirole ranges from 2 to 10 hours, with a mean of 6 hours, and as mentioned above, the drug metabolites are excreted in the urine.78,85
Positive_regulation (induced) of CYP1A2 in urine associated with nicotine addiction
16) Confidence 0.11 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857615 Disease Relevance 0.10 Pain Relevance 0.04
Parallel studies of theophylline pharmacokinetics showed heightened drug clearance compatible with induced cytochrome P-4501A2 in two patients, whereas increased activity of gamma-glutamyl transferase in serum suggested persisting induction of P-4502E1, as by ethanol, in several others.
Positive_regulation (induced) of cytochrome P-4501A2
17) Confidence 0.03 Published 1995 Journal Clin. Chim. Acta Section Abstract Doc Link 7554281 Disease Relevance 0.50 Pain Relevance 0.32

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