INT493

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Context Info
Confidence 0.02
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.32
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Treh) plasma membrane (Treh)
Anatomy Link Frequency
macrophages 2
diaphragm 1
Treh (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 12 100.00 Very High Very High Very High
antagonist 6 99.52 Very High Very High Very High
tetrodotoxin 1 99.32 Very High Very High Very High
local anesthetic 1 96.92 Very High Very High Very High
Nicotine 1 79.68 Quite High
Analgesic 1 77.76 Quite High
sodium channel 2 76.40 Quite High
Clonidine 2 63.36 Quite High
Kinase C 1 55.12 Quite High
Antinociceptive 6 50.00 Quite Low
Disease Link Frequency Relevance Heat
Post Operative Pain 4 91.08 High High
Convulsion 1 81.28 Quite High
Bordatella Infection 1 74.64 Quite High
INFLAMMATION 4 50.00 Quite Low
Vibrio Infection 1 25.00 Low Low
Inflammatory Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The surface AChRs exhibit pharmacological properties identical to those obtained for BC3H-1 cells, including the association and dissociation rates of alpha-bungarotoxin, a low affinity and cooperative instantaneous dose-response curve, cooperative steady state agonist binding and desensitization, cooperative enhancement of agonist binding affinity by local anesthetics, and distinct affinities for curariform antagonists.
alpha-bungarotoxin Binding (binding) of associated with antagonist, agonist and local anesthetic
1) Confidence 0.02 Published 1991 Journal J. Biol. Chem. Section Abstract Doc Link 1713208 Disease Relevance 0 Pain Relevance 0.34
Choline 100 mM reduced binding of alpha-bungarotoxin to macrophages by 72% and decreased their release of TNF by up to 51 (sd 11)%.
alpha-bungarotoxin Binding (binding) of in macrophages
2) Confidence 0.02 Published 2010 Journal Br J Anaesth Section Body Doc Link 20511332 Disease Relevance 0.07 Pain Relevance 0
In contrast to binding of alpha-bungarotoxin, binding of ATX II is not changed by denervation of the diaphragm.
alpha-bungarotoxin Binding (binding) of in diaphragm
3) Confidence 0.02 Published 1979 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 42854 Disease Relevance 0.08 Pain Relevance 0.17
We investigated the effect of genotype and choline treatment on alpha-bungarotoxin binding to, and their production of tumour necrosis factor (TNF) from, macrophages.
alpha-bungarotoxin Binding (binding) of in macrophages
4) Confidence 0.01 Published 2010 Journal Br J Anaesth Section Body Doc Link 20511332 Disease Relevance 0.09 Pain Relevance 0
We have recently found that the deoxynojirimycin-derivative emiglitate, a recognized inhibitor of intestinal alpha-glucosidehydrolase activity, is a powerful inhibitor of glucose-induced insulin release.
alpha-glucosidehydrolase Binding (recognized) of
5) Confidence 0.01 Published 1996 Journal Biosci. Rep. Section Abstract Doc Link 8861537 Disease Relevance 0.07 Pain Relevance 0.12
Although some competitive antagonists such as lophotoxin and alpha-bungarotoxin bind to the same high- and low-affinity sites as ACh, other cholinergic drugs may bind with opposite specificity.
alpha-bungarotoxin Binding (bind) of associated with antagonist
6) Confidence 0.01 Published 2000 Journal Neurochem. Int. Section Abstract Doc Link 10771117 Disease Relevance 0 Pain Relevance 0.34

General Comments

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