INT4931

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Context Info
Confidence 0.78
First Reported 1991
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 53
Total Number 53
Disease Relevance 33.25
Pain Relevance 13.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IFNG) extracellular region (IFNG)
Anatomy Link Frequency
T cells 13
monocytes 7
blood 4
mononuclear cells 4
macrophages 3
IFNG (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 285 100.00 Very High Very High Very High
Inflammation 206 100.00 Very High Very High Very High
Angina 16 99.12 Very High Very High Very High
Opioid 14 98.40 Very High Very High Very High
cINOD 24 98.04 Very High Very High Very High
anesthesia 25 97.16 Very High Very High Very High
aspirin 26 96.56 Very High Very High Very High
chemokine 25 95.96 Very High Very High Very High
Dynorphin 3 95.28 Very High Very High Very High
fibrosis 30 94.32 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 265 100.00 Very High Very High Very High
Necrosis 48 99.80 Very High Very High Very High
Cancer 149 99.62 Very High Very High Very High
Infection 139 99.60 Very High Very High Very High
Pneumonia 9 99.56 Very High Very High Very High
Sarcoidosis 54 99.48 Very High Very High Very High
Eosinophilia 2 99.48 Very High Very High Very High
Cv General 3 Under Development 19 99.12 Very High Very High Very High
Granuloma 12 98.98 Very High Very High Very High
Adhesions 7 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we provide evidence that NCX-4016 delivered to PMBC-derived T lymphocytes and monocytes causes a transitory inhibition of cell respiration and approximately 50% reduction of cellular ATP, which translates in a time-reversible inhibition of cell proliferation and IL-2, IL-4, IL-5, and IFN-gamma secretion.
Localization (secretion) of IFN-gamma in monocytes
1) Confidence 0.78 Published 2004 Journal J. Immunol. Section Abstract Doc Link 15240674 Disease Relevance 0.07 Pain Relevance 0.28
In contrast to Crohn’s disease, which is characterized by a predominant T-helper-1 cytokine profile with secretion of cytokines such as interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), the uncontrolled tissue damage in the mucosa and submucosa of UC patients appears to be fostered by humoral immunity with antibody-secreting plasma, T lymphocytes with a T-helper-2 cytokine profile, and neutrophils.
Localization (secretion) of interferon-gamma in neutrophils associated with inflammatory bowel disease, disease and cytokine
2) Confidence 0.78 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012439 Disease Relevance 1.52 Pain Relevance 0.29
The number of spots (interferon-gamma-secreting T cells) per 20,000 responding PBMC was reported.
Localization (-) of interferon-gamma in T cells
3) Confidence 0.78 Published 2005 Journal J Transl Med Section Body Doc Link PMC551593 Disease Relevance 0.35 Pain Relevance 0
In contrast to Crohn’s disease, which is characterized by a predominant T-helper-1 cytokine profile with secretion of cytokines such as interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), the uncontrolled tissue damage in the mucosa and submucosa of UC patients appears to be fostered by humoral immunity with antibody-secreting plasma, T lymphocytes with a T-helper-2 cytokine profile, and neutrophils.
Localization (secretion) of IFN-gamma in neutrophils associated with inflammatory bowel disease, disease and cytokine
4) Confidence 0.78 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012439 Disease Relevance 1.52 Pain Relevance 0.29
IL-18 immunoneutralization resulted in a 60-80% reduction of IL-1beta, IL-8, IFN-gamma, and TNF-alpha release from LPS-stimulated monocytes.
Localization (release) of IFN-gamma in monocytes
5) Confidence 0.78 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.15 Pain Relevance 0.25
Neopterin formation by human monocyte-derived macrophages and dendritic cells is induced by the pro-inflammatory cytokine interferon-gamma, which is released by activated T-lymphocytes.
Localization (released) of interferon-gamma in dendritic cells associated with inflammation and cytokine
6) Confidence 0.77 Published 2006 Journal Curr Vasc Pharmacol Section Abstract Doc Link 16842138 Disease Relevance 0.88 Pain Relevance 0.18
The T-helper 1 cells, that secrete interleukin-2 and interferon-gamma for example, are reduced in activity while the T-helper 2 cells, together with the macrophages, show an increased secretion of interleukins-6 and -10.
Localization (secrete) of interferon-gamma in macrophages
7) Confidence 0.74 Published 2005 Journal Expert Rev Clin Immunol Section Abstract Doc Link 20477658 Disease Relevance 0.99 Pain Relevance 0.14
The selective inhibition of the early generation of IFN-gamma and TNF-alpha from NK and gammadelta T cells by NSAIDs may serve to drive the subsequent acquired immune responses towards a Th2 phenotype, leading to the aggravation of allergic symptoms.
Localization (generation) of IFN-gamma in T cells associated with hypersensitivity and cinod
8) Confidence 0.73 Published 2006 Journal Exp. Dermatol. Section Abstract Doc Link 17083365 Disease Relevance 0.68 Pain Relevance 0.95
In concert with other pro-inflammatory cytokines, interferon-gamma is the most important trigger for the formation and release of reactive oxygen species (ROS).
Localization (release) of interferon-gamma associated with inflammation and cytokine
9) Confidence 0.72 Published 2006 Journal Curr Vasc Pharmacol Section Abstract Doc Link 16842138 Disease Relevance 1.18 Pain Relevance 0.16
Our results demonstrated that exposing LPS-stimulated human monocytes to NCX-4016 resulted in a 40-80% inhibition of IL-1beta, IL-8, IL-12, IL-18, IFN-gamma, and TNF-alpha release with an EC(50) of 10-20 microM for IL-1beta and IL-18.
Localization (release) of IFN-gamma in monocytes
10) Confidence 0.68 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.23 Pain Relevance 0.37
chain of the T-cell receptor (TCR) causing a massive release of cytokines, such as interferon-gamma (INF-?)
Localization (release) of interferon-gamma in T-cell associated with cytokine
11) Confidence 0.68 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 1.48 Pain Relevance 0.13
We found a significant enhancement of interferon-gamma (IFN-gamma) and soluble interleukin-2 receptor (sIL-2R) release in lipopolysaccharide (LPS)-stimulated whole blood cultures after induction of anesthesia.
Localization (release) of interferon-gamma in blood associated with anesthesia
12) Confidence 0.68 Published 2001 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 11710990 Disease Relevance 0.25 Pain Relevance 0.76
MBP, MOG, PLP, MAG), the presence of reactive T cells in blood and, further enriched, in the cerebrospinal fluid (CSF), large numbers of B cells in the CSF secreting antibodies of multiple but unknown specificities, an increase of mononuclear cells (MNC) expressing and secreting both pro- and anti-inflammatory cytokines, including Th1 cytokines interferon-gamma (IFN-gamma) and interleukin (IL)-6, the Th2 related IL-4 and IL-10, and the Th3-driven TGF-beta, elevated numbers of MNC in both blood and CSF expressing a spectrum of metalloproteinases and their inhibitors, as well as many other aberrations.
Localization (secreting) of interferon-gamma in T cells associated with inflammation, metalloproteinase and cytokine
13) Confidence 0.68 Published 2001 Journal Neurol. Sci. Section Abstract Doc Link 11603616 Disease Relevance 0.69 Pain Relevance 0.41
The number of spots (interferon-gamma-secreting T cells) per 20,000 responding PBMC was reported.
Localization (secreting) of interferon-gamma in T cells
14) Confidence 0.68 Published 2005 Journal J Transl Med Section Body Doc Link PMC551593 Disease Relevance 0.35 Pain Relevance 0
MBP, MOG, PLP, MAG), the presence of reactive T cells in blood and, further enriched, in the cerebrospinal fluid (CSF), large numbers of B cells in the CSF secreting antibodies of multiple but unknown specificities, an increase of mononuclear cells (MNC) expressing and secreting both pro- and anti-inflammatory cytokines, including Th1 cytokines interferon-gamma (IFN-gamma) and interleukin (IL)-6, the Th2 related IL-4 and IL-10, and the Th3-driven TGF-beta, elevated numbers of MNC in both blood and CSF expressing a spectrum of metalloproteinases and their inhibitors, as well as many other aberrations.
Localization (secreting) of IFN-gamma in T cells associated with inflammation, metalloproteinase and cytokine
15) Confidence 0.68 Published 2001 Journal Neurol. Sci. Section Abstract Doc Link 11603616 Disease Relevance 0.69 Pain Relevance 0.41
Patients with disseminated BCG and other infections present defects in IFN gamma and other cytokines secretion and action [33-35].
Localization (secretion) of IFN gamma associated with infection and cytokine
16) Confidence 0.67 Published 2004 Journal BMC Infect Dis Section Body Doc Link PMC529257 Disease Relevance 1.03 Pain Relevance 0.13
30% respond to antibiotics alone.9 In haematological malignancies, the most common manifestation of IFI is fungal pneumonia, often caused by moulds such as Aspergillus species.10
Localization (manifestation) of IFI associated with pneumonia
17) Confidence 0.62 Published 2010 Journal Journal of Antimicrobial Chemotherapy Section Body Doc Link PMC2837550 Disease Relevance 0.87 Pain Relevance 0
We evaluated the effect of timing of BE addition to the culture medium on thymidine uptake, the kinetics of expression of activation markers (CD69, CD25 and CD71) on CD4+ and CD8+ lymphocytes, and of class II MHC antigens on CD14+ cells (monocytes), the kinetics of interleukin-1 (IL-1), interleukin-2 (IL-2) and interferon gamma (IFN-gamma) release, and the cell cycle.
Localization (release) of interferon gamma in monocytes
18) Confidence 0.60 Published 1991 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 1763657 Disease Relevance 0 Pain Relevance 0.06
Mechanisms involving cell contact. [9] as well as soluble factors [10,11] have been proposed, particularly the involvement of interferon-gamma (IFN-?)
Localization (involvement) of interferon-gamma
19) Confidence 0.54 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575631 Disease Relevance 0.42 Pain Relevance 0.07
We evaluated the effect of timing of BE addition to the culture medium on thymidine uptake, the kinetics of expression of activation markers (CD69, CD25 and CD71) on CD4+ and CD8+ lymphocytes, and of class II MHC antigens on CD14+ cells (monocytes), the kinetics of interleukin-1 (IL-1), interleukin-2 (IL-2) and interferon gamma (IFN-gamma) release, and the cell cycle.
Localization (release) of IFN-gamma in monocytes
20) Confidence 0.52 Published 1991 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 1763657 Disease Relevance 0 Pain Relevance 0.06

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