INT49311

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Context Info
Confidence 0.26
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.95
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hprt) transferase activity, transferring glycosyl groups (Hprt) cytoplasm (Hprt)
Anatomy Link Frequency
L5178Y 1
Hprt (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 2 84.00 Quite High
Hippocampus 21 77.92 Quite High
anesthesia 15 25.92 Quite Low
Dopamine 7 5.00 Very Low Very Low Very Low
Substantia nigra 4 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
midbrain 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurologic Manifestations 3 99.62 Very High Very High Very High
Chromosome Aberrations 2 98.88 Very High Very High Very High
Lymphatic System Cancer 4 98.40 Very High Very High Very High
Rare Diseases 1 92.48 High High
Disease 123 88.48 High High
Cognitive Disorder 37 85.12 High High
Dystonia 48 68.08 Quite High
Hyperuricemia 19 34.76 Quite Low
Congenital Anomalies 18 32.68 Quite Low
Crystal Associated Disease 5 26.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CHO and L5178Y tk +/- mouse lymphoma cells were treated with PAP for 4 hr and assayed for 3 genetic endpoints: gene mutation at the HGPRT or TK locus, respectively; chromosomal aberrations at approximately 20 hr after initiation of treatment; and single-strand DNA breaks as detected by the single cell electrophoresis assay immediately after treatment.
HGPRT Binding (mutation) of in L5178Y associated with chromosome aberrations and lymphatic system cancer
1) Confidence 0.26 Published 1995 Journal Environ. Mol. Mutagen. Section Abstract Doc Link 7556113 Disease Relevance 0.43 Pain Relevance 0.08
Results were analyzed using SDS v.2.2 software and the expression data was normalized to mouse GAPDH and HPRT.
HPRT Binding (normalized) of
2) Confidence 0.25 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0 Pain Relevance 0.18
These studies provide the largest summary to date for the spectrum of neurological manifestations that can occur in association with HPRT deficiency.
HPRT Binding (association) of associated with neurologic manifestations
3) Confidence 0.25 Published 2010 Journal Brain Section Body Doc Link PMC2842514 Disease Relevance 0.52 Pain Relevance 0

General Comments

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