INT49324

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Context Info
Confidence 0.36
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.50
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Hgf) extracellular space (Hgf) cell morphogenesis (Hgf)
Anatomy Link Frequency
HGF 3
hepatocyte 2
lung 1
parenchyma 1
Hgf (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 62 99.20 Very High Very High Very High
Analgesic 5 88.60 High High
intrathecal 5 87.76 High High
Somatostatin 2 87.36 High High
cytokine 38 87.08 High High
antagonist 4 75.00 Quite High
Spinal cord 11 63.84 Quite High
imagery 37 57.04 Quite High
chemokine 7 52.96 Quite High
Inflammation 19 48.16 Quite Low
Disease Link Frequency Relevance Heat
Cancer 523 99.00 Very High Very High Very High
Motor Neuron Diseases 198 98.36 Very High Very High Very High
Granuloma 92 96.16 Very High Very High Very High
Disease Progression 12 95.12 Very High Very High Very High
Targeted Disruption 77 94.20 High High
Adenocarcinoma 4 93.28 High High
Glioblastoma 99 90.96 High High
Hyperplasia 5 89.88 High High
Thrombosis 5 87.12 High High
Brain Tumor 5 86.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This inhibitory effect of substance P action was confirmed by experiments performed on the bronchial apparatus of guinea-pigs known to possess tachykinin NK1 and NK2 receptors.
NK2 Binding (possess) of associated with substance p
1) Confidence 0.36 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7556407 Disease Relevance 0 Pain Relevance 0.50
Several putative functions for PCI in the developing mouse lung can be postulated: (1) PCI is directly involved in lung morphogenesis participating in branching of the bronchiolar tree by controlling extracellular proteolysis; (2) PCI is secreted into amniotic fluid and the lung may represent a source of PCI production and secretion into the amniotic fluid; (3) PCI could act through interaction with HGF which is expressed in lung mesenchyme (Sonnenberg et al. 1993); (4) notably, PCI expression could not be detected in the epithelia responsible for gas exchange in sacculi and alveoli at later stages of development.
HGF Binding (interaction) of in lung
2) Confidence 0.21 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.15 Pain Relevance 0
Further possible functions of PCI in the developing skin might involve protection from active proteases present in the amniotic fluid, such as uPA and tPA (Verkleij-Hagoort et al. 2007), or regulation of morphogen or growth factor supply in the epidermis, as PCI binds retinoids (Jerabek et al. 2001) and hepatocyte growth factor (HGF) both present in developing skin and amniotic fluid (Laurell et al. 1992; Srivastava et al. 1999).
HGF Binding (binds) of in hepatocyte
3) Confidence 0.20 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.28 Pain Relevance 0
Only EGF and IL-6 and not FGF, HGF, TGF-?
HGF Binding (Only) of in HGF
4) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.44 Pain Relevance 0
The HGF/c-Met interaction plays a pivotal role in cancer invasion that is mediated by the tumor stromal cell production of HGF [52], which can induce ECM degradation, tubule formation and angiogenesis [53].
HGF Binding (interaction) of in HGF associated with cancer
5) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.57 Pain Relevance 0
InlB has been shown to promote dynamin-dependent internalization of Listeria when the bacteria have access to the basolateral surface, and HGF similarly promotes internalization of E-cadherin when added to basal surfaces [59], [71].
HGF Binding (internalization) of in HGF
6) Confidence 0.16 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0.05 Pain Relevance 0
As an explanation for their highly invasive nature, we show that DBM2 tumors not only express both c-Met and uPAR, the receptor of urokinase signaling pathway, but also strongly respond to HGF (data not shown) indicating that the c-Met signaling pathway may play an important role in the invasion of DBM2 orthotopic tumors into the brain parenchyma [24,27,40,44].
HGF Neg (not) Binding (respond) of in parenchyma associated with cancer
7) Confidence 0.14 Published 2008 Journal J Transl Med Section Body Doc Link PMC2645376 Disease Relevance 1.84 Pain Relevance 0.05
Recombinant human hepatocyte growth factor (rh-HGF)
HGF Binding (Recombinant) of in hepatocyte
8) Confidence 0.11 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785861 Disease Relevance 0.67 Pain Relevance 0.08
may occur through binding of SP to other members of the NK family, for example, NK2 or NK3.

3.4.

NK2 Binding (example) of associated with substance p
9) Confidence 0.06 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817809 Disease Relevance 1.51 Pain Relevance 0.25

General Comments

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