INT4936

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Context Info
Confidence 0.80
First Reported 1980
Last Reported 2011
Negated 0
Speculated 4
Reported most in Abstract
Documents 125
Total Number 129
Disease Relevance 35.70
Pain Relevance 107.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tacr1) response to stress (Tacr1) cytoplasm (Tacr1)
signal transducer activity (Tacr1)
Anatomy Link Frequency
spinal cord 19
dorsal horn 15
neurons 9
dorsal root ganglion 8
spinal 7
Tacr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 2130 100.00 Very High Very High Very High
qutenza 302 100.00 Very High Very High Very High
Inflammation 301 100.00 Very High Very High Very High
Pain 166 100.00 Very High Very High Very High
Spinal cord 134 100.00 Very High Very High Very High
Neuropeptide 92 100.00 Very High Very High Very High
Calcitonin gene-related peptide 60 100.00 Very High Very High Very High
narcan 47 100.00 Very High Very High Very High
Neurotransmitter 37 100.00 Very High Very High Very High
Analgesic 33 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 290 100.00 Very High Very High Very High
Nociception 116 100.00 Very High Very High Very High
Urological Neuroanatomy 33 100.00 Very High Very High Very High
Ganglion Cysts 663 99.80 Very High Very High Very High
Inflammatory Pain 40 99.64 Very High Very High Very High
Pressure And Volume Under Development 41 99.48 Very High Very High Very High
Hyperalgesia 102 99.36 Very High Very High Very High
Neurogenic Inflammation 23 99.28 Very High Very High Very High
Rhinitis 6 99.00 Very High Very High Very High
Increased Venous Pressure Under Development 10 98.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The autoradiographic localization of substance P receptors in the rat and bovine spinal cord and the rat and cat spinal trigeminal nucleus pars caudalis and the effects of neonatal capsaicin.
Localization (localization) of substance P in spinal cord associated with qutenza, spinal cord and substance p
1) Confidence 0.80 Published 1985 Journal Brain Res. Section Title Doc Link 2986763 Disease Relevance 0 Pain Relevance 0.83
Immunoelectron microscopy revealed that NK1 receptor immunoreactivity was preferentially localized in peri-implant epithelial cells.
Localization (localized) of NK1 receptor in epithelial cells
2) Confidence 0.74 Published 2009 Journal Cell Tissue Res. Section Abstract Doc Link 19015883 Disease Relevance 0.05 Pain Relevance 0.19
To study the correlation between these two measures, we plotted substance P release against NK1 receptor internalization and fitted a saturation binding function to the points.
Localization (release) of NK1 receptor associated with substance p
3) Confidence 0.71 Published 2003 Journal Neuroscience Section Abstract Doc Link 12699788 Disease Relevance 0 Pain Relevance 1.10
Relationship between capsaicin-evoked substance P release and neurokinin 1 receptor internalization in the rat spinal cord.
Localization (release) of neurokinin 1 receptor in spinal cord associated with qutenza, spinal cord and substance p
4) Confidence 0.71 Published 2003 Journal Neuroscience Section Title Doc Link 12699788 Disease Relevance 0 Pain Relevance 1.07
Immunocytochemical localization of the neurokinin 1 receptor in rat dental pulp.
Localization (localization) of neurokinin 1 receptor in dental pulp
5) Confidence 0.70 Published 2005 Journal Arch. Histol. Cytol. Section Title Doc Link 16477146 Disease Relevance 0.18 Pain Relevance 0.35
Enhancement of angiogenesis by endogenous substance P release and neurokinin-1 receptors during neurogenic inflammation.
Localization (release) of neurokinin-1 associated with inflammation, neurogenic inflammation and substance p
6) Confidence 0.68 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 12660314 Disease Relevance 0.45 Pain Relevance 0.59
However, in the deeper layers of the spinal cord (V-X), there was no such correlation, and stimulation of joint nociceptors and formalin-induced inflammation produced the greatest proportion of Fos/neurokinin-1 co-localization, suggesting a particular role for substance P in the mediation of joint pain and inflammatory hyperalgesia.
Localization (localization) of neurokinin-1 in nociceptors associated with pain, arthralgia, hyperalgesia, inflammation, nociceptor, substance p and spinal cord
7) Confidence 0.62 Published 1999 Journal Neuroscience Section Abstract Doc Link 10051214 Disease Relevance 0.69 Pain Relevance 0.78
In acute inflammatory pain there is ongoing release of substance P (SP) as measured by SPR internalization in lamina I neurons at both 8 and 60 min after formalin injection.
Localization (release) of substance P in lamina associated with ipn and substance p
8) Confidence 0.61 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10460273 Disease Relevance 0.89 Pain Relevance 1.03
Release of substance P into the superficial dorsal horn following nociceptive activation of the hindpaw of the rat.
Localization (Release) of substance P in dorsal horn associated with nociception, pain, dorsal horn and substance p
9) Confidence 0.61 Published 1991 Journal Brain Res. Section Title Doc Link 1726066 Disease Relevance 0.35 Pain Relevance 0.83
The aim of the present in vivo microdialysis study was to determine the possible contribution of N-methyl-D-aspartate (NMDA) or alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate (KA) receptors to capsaicin-induced release of substance P-like immunoreactivity (SP-LI) in the dorsal horn of the rat.
Localization (release) of substance P-like immunoreactivity in dorsal horn associated with qutenza, dorsal horn and substance p
10) Confidence 0.61 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11742721 Disease Relevance 0 Pain Relevance 0.70
Substance P (SP), released from thin afferent terminals, is believed to be a neurotransmitter for pain transmission in the spinal dorsal horn.
Localization (released) of Substance P in dorsal horn associated with pain, neurotransmitter, spinal dorsal horn and substance p
11) Confidence 0.61 Published 1992 Journal Acupunct Electrother Res Section Abstract Doc Link 1376550 Disease Relevance 0.16 Pain Relevance 0.98
Capsaicin, the hot extract of pepper, releases substance P (SP) from nonmyelinated sensory nerve endings and causes acute bronchoconstriction and airway microvascular leakiness.
Localization (releases) of substance P in sensory nerve associated with qutenza and substance p
12) Confidence 0.61 Published 1991 Journal J. Appl. Physiol. Section Abstract Doc Link 1713907 Disease Relevance 0.07 Pain Relevance 0.69
Increased release of substance P (SP) from the dorsal horn following noxious stimuli, such as spinal administration of capsaicin, has been demonstrated in previous studies.
Localization (release) of substance P in spinal associated with qutenza, dorsal horn and substance p
13) Confidence 0.61 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 17101224 Disease Relevance 0 Pain Relevance 0.84
Intradermal injection of capsaicin induces acute substance P release from rat spinal cord dorsal horn.
Localization (release) of substance P in spinal cord dorsal horn associated with qutenza, dorsal horn, spinal cord and substance p
14) Confidence 0.61 Published 2006 Journal Neurosci. Lett. Section Title Doc Link 17101224 Disease Relevance 0 Pain Relevance 1.44
Morphine has a dual concentration-dependent effect on K(+)-evoked substance P release from rat peripheral airways.
Localization (release) of substance P associated with substance p and morphine
15) Confidence 0.61 Published 1997 Journal Pulm Pharmacol Ther Section Title Doc Link 9695145 Disease Relevance 0.17 Pain Relevance 1.42
To investigate whether these lung opioid binding sites are functional receptors, this study was designed to determine (using superfusion) whether morphine modulates the K(+)-evoked release of the pro-inflammatory neuropeptide, substance P (SP), from rat peripheral airways.
Localization (release) of substance P in lung associated with inflammation, neuropeptide, opioid, substance p and morphine
16) Confidence 0.61 Published 1997 Journal Pulm Pharmacol Ther Section Abstract Doc Link 9695145 Disease Relevance 0.18 Pain Relevance 1.44
Compound 48/80 does not activate nerve fibres to cause release of substance P as it is equally effective in eliciting an inflammatory response in the presence of 100 micrograms of the substance P antagonist D-Pro4, D-Trp7,9,10 SP(4-11) in the synovial cavity.
Localization (release) of substance P in cavity associated with inflammatory response, antagonist and substance p
17) Confidence 0.61 Published 1989 Journal Neurosci. Lett. Section Abstract Doc Link 2484727 Disease Relevance 0.44 Pain Relevance 1.07
N-type calcium channels modulate the release of key pro-nociceptive neurotransmitters such as glutamate and substance P (SP) in the central nervous system.
Localization (release) of substance P in central nervous system associated with nociception, glutamate, neurotransmitter, calcium channel, central nervous system and substance p
18) Confidence 0.61 Published 2002 Journal Pain Section Abstract Doc Link 11932068 Disease Relevance 0.15 Pain Relevance 0.81
The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.
Localization (release) of substance P in spinal cord associated with antinociception, nociceptor, calcium channel, spinal cord, substance p and intrathecal
19) Confidence 0.61 Published 2002 Journal Pain Section Title Doc Link 11932068 Disease Relevance 0.23 Pain Relevance 1.23
Small diameter afferent neurons release substance P (SP), a mediator of both hyperalgesia and neurogenic extravasation.
Localization (release) of substance P in afferent neurons associated with hyperalgesia and substance p
20) Confidence 0.61 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11786220 Disease Relevance 0.87 Pain Relevance 1.05

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