INT49360

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Context Info
Confidence 0.76
First Reported 1995
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 22
Total Number 27
Disease Relevance 6.96
Pain Relevance 4.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
plasma 4
gray matter 1
muscles 1
brain 1
corpus callosum 1
Igf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 3 99.64 Very High Very High Very High
Hippocampus 25 99.20 Very High Very High Very High
Somatostatin 21 98.28 Very High Very High Very High
ischemia 31 97.90 Very High Very High Very High
Nerve growth factor 8 97.68 Very High Very High Very High
Central nervous system 51 97.32 Very High Very High Very High
imagery 16 97.20 Very High Very High Very High
gABA 21 96.68 Very High Very High Very High
Central grey 30 96.64 Very High Very High Very High
antagonist 26 96.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatitis 12 98.60 Very High Very High Very High
Cv Unclassified Under Development 30 97.90 Very High Very High Very High
Hypoxia 25 97.72 Very High Very High Very High
Critical Illness 9 96.68 Very High Very High Very High
Urological Neuroanatomy 34 96.64 Very High Very High Very High
Pycnodysostosis 5 96.52 Very High Very High Very High
Stress 70 94.56 High High
Growth Problems 5 93.88 High High
INFLAMMATION 14 91.52 High High
Alzheimer's Dementia 23 91.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: GH modulates the development of acute pancreatitis in the presence of active sensory nerves probably via stimulation of IGF-1 release.
Localization (release) of IGF-1 in sensory nerves associated with pancreatitis
1) Confidence 0.76 Published 2009 Journal Growth Horm. IGF Res. Section Abstract Doc Link 19615927 Disease Relevance 0.60 Pain Relevance 0.15
The inhibitory effects of IGF-I on hippocampal ACh release were not additive to those of either muscimol or baclofen, but were attenuated by GABA antagonists, bicuculline and phaclofen.
Localization (release) of IGF-I associated with gaba and antagonist
2) Confidence 0.74 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421625 Disease Relevance 0 Pain Relevance 0.55
The effects of IGF-I on hippocampal ACh release was sensitive to the Na(+) channel blocker tetrodotoxin, suggesting that IGF-I might act indirectly via the release of other transmitters/modulators.
Localization (release) of IGF-I associated with tetrodotoxin
3) Confidence 0.74 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421625 Disease Relevance 0 Pain Relevance 0.49
Serum IGF-1 levels were normal in four “other” patients (15.4%) at week 0 and in 12 “other” patients (46.2%) at week 24 or early termination.Fig. 2Serum IGF-1 concentrations at baseline versus week 24 or early termination for switch patients who had these values available at both time points (n = 32)
Localization (Serum) of IGF-1
4) Confidence 0.73 Published 2009 Journal Pituitary Section Body Doc Link PMC2855862 Disease Relevance 0.07 Pain Relevance 0.25
A small part of the initial clearance of IGF-1 does seem to be directly into blood via the periventricular tissue and choroid plexuses as occurs with sA?
Localization (clearance) of IGF-1 in choroid
5) Confidence 0.71 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1190198 Disease Relevance 0 Pain Relevance 0
In support of this, in the experiments where the IGF-1 was infused into the parenchyma and injured the tissue, much of the radioactivity was found in the edematous corpus callosum (Fig. 1C and 1D).
Localization (infused) of IGF-1 in corpus callosum
6) Confidence 0.71 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1190198 Disease Relevance 0.40 Pain Relevance 0.15
The tissue profiles showed some penetration of IGF-1 into the brain immediately adjacent to the CSF (Fig. 9A, caudate-putamen; Fig. 9B, periaqueductal gray matter) over the first 9 min when blood-contained radioactivity was low (Fig. 3).
Localization (penetration) of IGF-1 in gray matter associated with central grey
7) Confidence 0.71 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1190198 Disease Relevance 0.17 Pain Relevance 0.09
Rapid clearance of IGF-1 and I-sA?
Localization (clearance) of IGF-1
8) Confidence 0.71 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1190198 Disease Relevance 0.09 Pain Relevance 0
Also, we do not know whether IGF-I is acting here independent of 17?
Localization (acting) of IGF-I
9) Confidence 0.70 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.12 Pain Relevance 0
Determination of IGFPB3, IGF-1, and GH Levels
Localization (Determination) of IGF-1
10) Confidence 0.70 Published 2010 Journal Protein J Section Body Doc Link PMC2951508 Disease Relevance 0 Pain Relevance 0
Second, the elevated plasma/serum IGF-1 levels could be the result of increased expression of proteases releasing IGF-1 from the ternary complex (IGF-1 + IGFBP3 + acid-labile protein), which is also secreted in response to ischeamia [3].
Localization (secreted) of IGF-1 in plasma
11) Confidence 0.70 Published 2010 Journal Protein J Section Body Doc Link PMC2951508 Disease Relevance 0.64 Pain Relevance 0.05
Using in vitro slice preparations, we have earlier reported that IGF-I potently inhibits K(+)-evoked endogenous acetylcholine (ACh) release from the adult rat hippocampus and cortex but not from the striatum.
Neg (not) Localization (release) of IGF-I in striatum associated with hippocampus
12) Confidence 0.70 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421625 Disease Relevance 0 Pain Relevance 0.42
Because GH and IGF-I release remained unchanged when pituitaries were incubated alone with hGH, the site of IGF-I release and GH feedback is most likely at the hypothalamic level.
Localization (release) of IGF-I
13) Confidence 0.66 Published 1995 Journal Neuroendocrinology Section Abstract Doc Link 7617136 Disease Relevance 0 Pain Relevance 0.18
To determine whether IGF-I is released from hypothalamus or pituitary in response to GH, tissues were tested separately in static incubation.
Localization (released) of IGF-I in pituitary
14) Confidence 0.66 Published 1995 Journal Neuroendocrinology Section Abstract Doc Link 7617136 Disease Relevance 0.06 Pain Relevance 0.29
Because GH and IGF-I release remained unchanged when pituitaries were incubated alone with hGH, the site of IGF-I release and GH feedback is most likely at the hypothalamic level.
Localization (release) of IGF-I
15) Confidence 0.66 Published 1995 Journal Neuroendocrinology Section Abstract Doc Link 7617136 Disease Relevance 0 Pain Relevance 0.19
Second, the elevated plasma/serum IGF-1 levels could be the result of increased expression of proteases releasing IGF-1 from the ternary complex (IGF-1 + IGFBP3 + acid-labile protein), which is also secreted in response to ischeamia [3].
Localization (releasing) of IGF-1 in plasma
16) Confidence 0.66 Published 2010 Journal Protein J Section Body Doc Link PMC2951508 Disease Relevance 0.61 Pain Relevance 0.04
Second, the elevated plasma/serum IGF-1 levels could be the result of increased expression of proteases releasing IGF-1 from the ternary complex (IGF-1 + IGFBP3 + acid-labile protein), which is also secreted in response to ischeamia [3].
Localization (secreted) of IGF-1 in plasma
17) Confidence 0.66 Published 2010 Journal Protein J Section Body Doc Link PMC2951508 Disease Relevance 0.61 Pain Relevance 0.05
Second, the elevated plasma/serum IGF-1 levels could be the result of increased expression of proteases releasing IGF-1 from the ternary complex (IGF-1 + IGFBP3 + acid-labile protein), which is also secreted in response to ischeamia [3].
Localization (secreted) of IGF-1 in plasma
18) Confidence 0.66 Published 2010 Journal Protein J Section Body Doc Link PMC2951508 Disease Relevance 0.62 Pain Relevance 0.05
In a later study with the same hypoxia-ischemia model and intraventricular infusion protocol, Guan et al [38] investigated the cellular distribution of 3H-IGF-1 and its co-localization with immunoreactive IGFBP-2 at 30 min and 6 hr after administration.
Localization (localization) of 3H-IGF-1 associated with hypoxia and ischemia
19) Confidence 0.62 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1190198 Disease Relevance 0.44 Pain Relevance 0.12
To determine osteocalcin (OC), insulin growth factor-1 (IGF-1), collagen1?
Spec (determine) Localization (osteocalcin) of IGF-1
20) Confidence 0.62 Published 2008 Journal Langenbecks Arch Surg Section Body Doc Link PMC2814041 Disease Relevance 0 Pain Relevance 0

General Comments

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