INT49361

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Context Info
Confidence 0.45
First Reported 1995
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.15
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Igf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 10 99.98 Very High Very High Very High
agonist 3 97.08 Very High Very High Very High
Hippocampus 3 94.32 High High
cytokine 52 93.04 High High
Angina 3 79.76 Quite High
antidepressant 2 75.00 Quite High
ischemia 26 59.12 Quite High
tolerance 6 58.64 Quite High
Inflammation 3 52.96 Quite High
analgesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Precocious Puberty 7 100.00 Very High Very High Very High
Urological Neuroanatomy 7 100.00 Very High Very High Very High
Sepsis 37 97.88 Very High Very High Very High
Cognitive Disorder 3 95.52 Very High Very High Very High
Cv General 3 Under Development 3 79.76 Quite High
Coronary Artery Disease 10 72.80 Quite High
Cv Unclassified Under Development 24 59.12 Quite High
Reperfusion Injury 21 53.84 Quite High
INFLAMMATION 3 52.96 Quite High
Peritonitis 1 52.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is possible that FLX affect FC neuroplasticity through activation of the IGF-1 system.
Spec (possible) Regulation (affect) of Positive_regulation (activation) of IGF-1 associated with urological neuroanatomy and fluoxetine
1) Confidence 0.45 Published 2008 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17961991 Disease Relevance 0.77 Pain Relevance 1.05
These differences in SOCS expression appeared independent of the induction of mRNA of the GHR or of IGF-I.
Neg (independent) Spec (appeared) Regulation (independent) of Positive_regulation (induction) of IGF-I
2) Confidence 0.34 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.45 Pain Relevance 0.14
Serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 levels are increased in central precocious puberty: effects of two different treatment regimens with gonadotropin-releasing hormone agonists, without or in combination with an antiandrogen (cyproterone acetate).
Regulation (effects) of Positive_regulation (increased) of IGF-I associated with precocious puberty and agonist
3) Confidence 0.05 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 7559897 Disease Relevance 0.50 Pain Relevance 0.09
However, a reduction in mitochondrial ROS formation, increased coronary circulation, increased levels of antioxidants such as manganese superoxide dismutase and catalase, altered expression of mitochondrial and sarcoplasmic KATP channels, and altered gene/protein expression/activation of factors such as HSP and IGF-1 may contribute to exercise-induced cardioprotection [62].
Regulation (altered) of Positive_regulation (activation) of IGF-1
4) Confidence 0.04 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872846 Disease Relevance 0.44 Pain Relevance 0.22

General Comments

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