INT49362

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Context Info
Confidence 0.65
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.26
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
plasma 2
gonadal 2
sensory nerves 2
Igf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 3 97.20 Very High Very High Very High
qutenza 3 89.60 High High
agonist 2 85.68 High High
Inflammatory mediators 1 84.48 Quite High
Demyelination 2 84.00 Quite High
Clonidine 2 60.28 Quite High
Angina 1 50.00 Quite Low
Inflammation 2 44.48 Quite Low
Disease Link Frequency Relevance Heat
Pancreatitis 11 98.90 Very High Very High Very High
Pycnodysostosis 5 96.92 Very High Very High Very High
Growth Problems 5 94.28 High High
Precocious Puberty 7 91.40 High High
INFLAMMATION 3 84.48 Quite High
Atherosclerosis 13 84.28 Quite High
Infarction 1 73.60 Quite High
Apoptosis 3 70.68 Quite High
Demyelinating Disease 2 68.20 Quite High
Myocardial Infarction 6 67.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: GH modulates the development of acute pancreatitis in the presence of active sensory nerves probably via stimulation of IGF-1 release.
Positive_regulation (stimulation) of Localization (release) of IGF-1 in sensory nerves associated with pancreatitis
1) Confidence 0.65 Published 2009 Journal Growth Horm. IGF Res. Section Abstract Doc Link 19615927 Disease Relevance 0.61 Pain Relevance 0.15
Second, the elevated plasma/serum IGF-1 levels could be the result of increased expression of proteases releasing IGF-1 from the ternary complex (IGF-1 + IGFBP3 + acid-labile protein), which is also secreted in response to ischeamia [3].
Positive_regulation (increased) of Localization (releasing) of IGF-1 in plasma
2) Confidence 0.44 Published 2010 Journal Protein J Section Body Doc Link PMC2951508 Disease Relevance 0.62 Pain Relevance 0.04
It is generally believed that gonadal sex steroids stimulate pulsatile GH secretion, which, in turn, stimulates insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3) production.
Positive_regulation (stimulate) of Localization (secretion) of IGF-I in gonadal
3) Confidence 0.09 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7559897 Disease Relevance 0.50 Pain Relevance 0.08
GH therapy markedly increases IGF-I secretion and improves their linear growth.
Positive_regulation (increases) of Localization (secretion) of IGF-I
4) Confidence 0.05 Published 2001 Journal Metab. Clin. Exp. Section Abstract Doc Link 11474477 Disease Relevance 0.54 Pain Relevance 0.25

General Comments

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