INT4937

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Context Info
Confidence 0.59
First Reported 1974
Last Reported 2010
Negated 3
Speculated 8
Reported most in Abstract
Documents 224
Total Number 232
Disease Relevance 44.51
Pain Relevance 171.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)
Anatomy Link Frequency
brain 13
NG108-15 4
amygdala 4
cortex 3
vas deferens 3
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 1344 100.00 Very High Very High Very High
Opioid 808 100.00 Very High Very High Very High
Morphine 554 100.00 Very High Very High Very High
narcan 479 100.00 Very High Very High Very High
antagonist 310 100.00 Very High Very High Very High
Enkephalin 303 100.00 Very High Very High Very High
agonist 295 100.00 Very High Very High Very High
Pain 270 100.00 Very High Very High Very High
Endogenous opioid 90 100.00 Very High Very High Very High
mu opioid receptor 69 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 126 100.00 Very High Very High Very High
Depression 55 100.00 Very High Very High Very High
Opiate Addiction 45 100.00 Very High Very High Very High
Eating Disorder 4 99.90 Very High Very High Very High
Dyskinesias 6 99.86 Very High Very High Very High
Lordosis 8 99.84 Very High Very High Very High
Sprains And Strains 15 99.82 Very High Very High Very High
Hyperalgesia 48 99.76 Very High Very High Very High
INFLAMMATION 45 99.76 Very High Very High Very High
Hemorrhage 9 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subsequent studies, employing in vitro preparations, have reported evidence of opioid receptor down-regulation under specific conditions.
Negative_regulation (down-regulation) of opioid receptor associated with opioid receptor
1) Confidence 0.59 Published 1989 Journal Life Sci. Section Abstract Doc Link 2542709 Disease Relevance 0.07 Pain Relevance 0.76
Juvenile isolation increased general activity during the social interaction test, an effect which was accompanied by a reduction of opioid receptor occupancy in many brain areas, suggesting an increased opioid peptide release as a consequence of socially-induced general activity.
Negative_regulation (reduction) of opioid receptor in brain associated with opioid receptor and opioid
2) Confidence 0.59 Published 1999 Journal Brain Res. Section Abstract Doc Link 10350555 Disease Relevance 0 Pain Relevance 1.03
Additionally, it is suggested that chronic exposure to pain produces a constant elevation of opioid peptides leading to opioid receptor downregulation and consequently morphine tolerance.
Negative_regulation (downregulation) of opioid receptor associated with pain, tolerance, opioid receptor, opioid and morphine
3) Confidence 0.59 Published 1995 Journal Brain Res. Section Abstract Doc Link 8925291 Disease Relevance 0.38 Pain Relevance 1.31
Previous study has demonstrated that chronic treatment of [D-Ala2,D-Leu5] enkephalin (DADLE) induces profound down-regulation of delta opioid receptor in rat brain.
Negative_regulation (down-regulation) of delta opioid receptor in brain associated with opioid receptor and enkephalin
4) Confidence 0.59 Published 1998 Journal Chin J Physiol Section Abstract Doc Link 10099869 Disease Relevance 0 Pain Relevance 0.48
There is only a transient decrease of DOR-1 mRNA level in midbrain region that occurred after a three-day treatment.
Negative_regulation (decrease) of DOR-1 mRNA in midbrain associated with midbrain
5) Confidence 0.59 Published 1998 Journal Chin J Physiol Section Abstract Doc Link 10099869 Disease Relevance 0 Pain Relevance 0.65
Naltrexone disrupts this feedback control by reducing micro opioid receptor function, thereby up-regulating delta opioid receptor binding, which results in an enhanced NK cell cytolytic response to delta opioid receptor ligands.
Negative_regulation (reducing) of opioid receptor in NK cell associated with opioid receptor
6) Confidence 0.58 Published 2004 Journal J. Immunol. Section Abstract Doc Link 15210757 Disease Relevance 0.08 Pain Relevance 0.74
Hydrolysis of casein accelerates gastrointestinal transit via reduction of opioid receptor agonists released from casein in rats.
Negative_regulation (reduction) of opioid receptor associated with narcan, agonist and opioid receptor
7) Confidence 0.58 Published 2005 Journal Biol. Neonate Section Title Doc Link 15572871 Disease Relevance 0 Pain Relevance 0.33
Using an antibody generated against the delta opioid receptor (DOR-1), it was found that DOR-1 like immunoreactivity was reduced in cortex and amygdala in mice following single and chronic PTZ administration.
Negative_regulation (reduced) of DOR-1 in amygdala associated with opioid receptor and amygdala
8) Confidence 0.54 Published 1996 Journal Epilepsy Res. Section Abstract Doc Link 8985692 Disease Relevance 0.14 Pain Relevance 0.27
It is not known whether local opioid receptor blockade in either of these regions will produce similar effects on food intake.
Spec (whether) Negative_regulation (blockade) of opioid receptor associated with opioid receptor
9) Confidence 0.53 Published 2000 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 10896868 Disease Relevance 0 Pain Relevance 0.47
Antisense inhibition of delta-opioid receptor gene function in vivo by peptide nucleic acids.
Negative_regulation (inhibition) of delta-opioid receptor associated with analgesic and opioid receptor
10) Confidence 0.52 Published 2000 Journal Mol. Pharmacol. Section Title Doc Link 10727518 Disease Relevance 0 Pain Relevance 0.36
Previously, we have used the biochemical receptor binding method to investigate whether down-regulation of the opioid receptor is a mechanism for morphine tolerance, and we were led to a negative conclusion.
Spec (whether) Negative_regulation (regulation) of opioid receptor associated with tolerance, opioid receptor and morphine
11) Confidence 0.49 Published 2000 Journal Proc. Natl. Sci. Counc. Repub. China B Section Abstract Doc Link 10786934 Disease Relevance 0 Pain Relevance 0.48
This effect of naloxone was reversed by the addition of morphine, suggesting that naloxone produced its effect by inhibiting the endogenous activity of opioid receptor.
Negative_regulation (inhibiting) of opioid receptor associated with narcan, opioid receptor and morphine
12) Confidence 0.45 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9756350 Disease Relevance 0.15 Pain Relevance 1.09
The delta opioid receptor, a member of the G-protein-coupled receptor superfamily, was used as a model system to characterize opioid receptor downregulation.
Negative_regulation (downregulation) of opioid receptor associated with opioid receptor
13) Confidence 0.44 Published 2000 Journal DNA Cell Biol. Section Abstract Doc Link 10701775 Disease Relevance 0 Pain Relevance 0.34
Both social activity and opioid receptor occupancy were unaffected by morphine treatment in non-isolated rats.
Neg (unaffected) Negative_regulation (unaffected) of opioid receptor associated with opioid receptor and morphine
14) Confidence 0.43 Published 1999 Journal Brain Res. Section Abstract Doc Link 10350555 Disease Relevance 0 Pain Relevance 1.27
Therefore, although mechanisms other than a specific opioid receptor blockade by naloxone must be considered, an involvement of opioid peptides in the effects of ethanol cannot be discounted.
Negative_regulation (blockade) of opioid receptor associated with narcan, opioid receptor and opioid
15) Confidence 0.43 Published 1987 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 3110844 Disease Relevance 0 Pain Relevance 0.37
Effects of food deprivation and high fat diet on opioid receptor binding in rat brain.
Negative_regulation (deprivation) of opioid receptor in brain associated with narcan and opioid receptor
16) Confidence 0.43 Published 1986 Journal Neurosci. Lett. Section Title Doc Link 3027625 Disease Relevance 0 Pain Relevance 0.28
The results were interpreted as supporting the theory that alcohol drinking is reinforced through its interaction with the endogenous opioid system and can compensate for deficiencies in opioid receptor activity.
Negative_regulation (deficiencies) of opioid receptor associated with endogenous opioid, opioid receptor and alcohol
17) Confidence 0.43 Published 1991 Journal Alcohol Section Abstract Doc Link 1651736 Disease Relevance 0 Pain Relevance 0.49
These disturbances were absent in rats subjected to prenatal stress under conditions of opioid receptor blockade with naltrexone.
Negative_regulation (blockade) of opioid receptor associated with stress and opioid receptor
18) Confidence 0.43 Published 2003 Journal Bull. Exp. Biol. Med. Section Abstract Doc Link 12910275 Disease Relevance 0.34 Pain Relevance 0.22
The influence of naltrexone-induced opioid receptor blockade on the response of thyrotropin to two different acute stressors was studied in adult male rats.
Negative_regulation (blockade) of opioid receptor associated with opioid receptor
19) Confidence 0.43 Published 1990 Journal Brain Res. Bull. Section Abstract Doc Link 2171723 Disease Relevance 0.16 Pain Relevance 0.27
Thus, the result of this study did not suggest that alteration in transcription of gene-encoding delta-opioid receptor was responsible for the down-regulation of delta-opioid receptor associated with the development of tolerance to DADLE.
Negative_regulation (down-regulation) of delta-opioid receptor associated with tolerance and opioid receptor
20) Confidence 0.43 Published 1998 Journal Chin J Physiol Section Abstract Doc Link 10099869 Disease Relevance 0 Pain Relevance 0.64

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