INT49370

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Context Info
Confidence 0.81
First Reported 1995
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 9.85
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGFBP3) extracellular region (IGFBP3) nucleus (IGFBP3)
Anatomy Link Frequency
plasma 3
nucleus 2
neurons 2
liver 1
brains 1
IGFBP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 9 93.92 High High
Inflammatory mediators 1 91.52 High High
alcohol 10 91.20 High High
agonist 2 87.84 High High
cocaine 9 80.72 Quite High
Clonidine 12 77.04 Quite High
nMDA receptor 9 72.48 Quite High
Neuropeptide 27 64.72 Quite High
Bioavailability 27 63.44 Quite High
Angina 2 56.88 Quite High
Disease Link Frequency Relevance Heat
Sleep Disorders 621 99.08 Very High Very High Very High
Thyroiditis 3 98.74 Very High Very High Very High
Thyroid Disease 86 97.86 Very High Very High Very High
Cancer 69 97.80 Very High Very High Very High
Apoptosis 243 96.76 Very High Very High Very High
Growth Problems 14 95.56 Very High Very High Very High
Malignant Neoplastic Disease 24 94.56 High High
Adenoma 141 92.96 High High
Hypoxia 9 92.80 High High
INFLAMMATION 15 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IGFBP-3 can translocate to the nucleus [16-18] to regulate cell growth and modulate the expression of genes associated with proliferation and apoptosis [7,19].
Localization (translocate) of IGFBP-3 in nucleus associated with apoptosis
1) Confidence 0.81 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 0.75 Pain Relevance 0.06
Correlation of plasma IGFBP-3 and tissue IGFBP-3 was assessed by Spearman's correlation coefficient.
Localization (Correlation) of tissue IGFBP-3 in plasma
2) Confidence 0.66 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.01 Pain Relevance 0
Correlation of plasma IGFBP-3 and tissue IGFBP-3 was assessed by Spearman's correlation coefficient.
Localization (Correlation) of plasma IGFBP-3 in plasma
3) Confidence 0.66 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.00 Pain Relevance 0
IGFBP-1, IGFBP-2, IGFBP-3, IGFBP-4 and IGFBP-5 localized in the cytoplasm of sSMCs and in the extracellular matrix.
Localization (localized) of IGFBP-3 in extracellular matrix
4) Confidence 0.55 Published 1996 Journal Regul. Pept. Section Abstract Doc Link 8988513 Disease Relevance 0.17 Pain Relevance 0.06
The IGFBP3 protein is primarily produced and secreted by the liver and is the major carrier of insulin-like growth factors 1 and 2 (IGF1, IGF2) in the blood.
Localization (secreted) of IGFBP3 in liver
5) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.28 Pain Relevance 0
All neurons showing colocalization of IGFBP3 and HCRT appeared to have a reduced hypocretin signal.
Localization (colocalization) of IGFBP3 in neurons
6) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.22 Pain Relevance 0.03
Of note, the proapoptotic effects commence with IGFBP3 translocation into the nucleus and binding of the retinoid-X-receptor-?
Localization (translocation) of IGFBP3 in nucleus
7) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.79 Pain Relevance 0
IGFBP3 is co-localized in hypocretin producing cells in mouse brains
Localization (localized) of IGFBP3 in brains
8) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.20 Pain Relevance 0.07
As a control, Melanin Concentrating Hormone (MCH) expression was also studied and found to be unaffected by hIGFBP3 overexpression or Igfbp3 absence (Fig. 3D).


Neg (absence) Localization (absence) of Igfbp3
9) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.95 Pain Relevance 0
To investigate coexpression of HCRT and Igfbp3, we performed Igfbp3 ISH followed by HCRT immunostaining.
Localization (followed) of Igfbp3
10) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.20 Pain Relevance 0.03
As the protein is co-localized with HCRT, IGFBP3 could have been an autoantigen involved in the hypothesized autoimmune attack directed against the HCRT neurons.
Localization (localized) of IGFBP3 in neurons
11) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.39 Pain Relevance 0
IGFBP3 is localized in human hypocretin producing cells
Localization (localized) of IGFBP3
12) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0 Pain Relevance 0.05
Similarly, Bona et al. [28] documented that in the patients with hypothyroidism - both congenital and caused by thyroiditis - L-T4 replacement led to physiological increase of IGF-I and IGFBP-3 secretion.
Localization (secretion) of IGFBP-3 associated with thyroiditis and thyroid disease
13) Confidence 0.45 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2858102 Disease Relevance 0.99 Pain Relevance 0
In all the children IGF-I and IGFBP-3 secretion was measured in a single blood sample during in morning hours.
Localization (secretion) of IGFBP-3 in blood
14) Confidence 0.45 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2858102 Disease Relevance 0.05 Pain Relevance 0
Moreover, after 1 year of rhGH administration there were no significant differences either in IGF-I secretion or in IGF-I/IGFBP-3 molar ratio between the groups of children who were euthyroid all the time and the other one, grouping children who required L-T4 substitution.
Localization (secretion) of IGFBP-3 in molar
15) Confidence 0.42 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2858102 Disease Relevance 0.12 Pain Relevance 0
Recently however, proapoptotic effects of IGFBP3 independent of nuclear translocation and protein secretion have been demonstrated, suggesting additional cytoplasmic pathways also promote apoptosis [30].
Localization (secretion) of IGFBP3 associated with apoptosis
16) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.92 Pain Relevance 0.04
The subcutaneously administration of rhIGF1 does not correct the low circulating levels of IGFBP-3 and ALS and therefore the clearance of rhIGF1 is accelerated and the tissue distribution affected.33 Moreover, it has been described that prolonged administration of rhIGF1 leads to generation of IGFBP-3 and ALS and other binding proteins, requiring sometimes a reduction of rhIGF1 dosage to prevent adverse effects.2 The possible direct effect of GH on skeletal growth should also be considered.
Localization (generation) of IGFBP-3
17) Confidence 0.39 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0.07 Pain Relevance 0
Effect of zinc supplementation on growth hormone secretion, IGF-I, IGFBP-3, somatomedin generation, alkaline phosphatase, osteocalcin and growth in prepubertal children with idiopathic short stature.
Localization (secretion) of IGFBP-3 associated with growth problems
18) Confidence 0.29 Published 2005 Journal J. Pediatr. Endocrinol. Metab. Section Title Doc Link 15679071 Disease Relevance 0.23 Pain Relevance 0.07
Second, the elevated plasma/serum IGF-1 levels could be the result of increased expression of proteases releasing IGF-1 from the ternary complex (IGF-1 + IGFBP3 + acid-labile protein), which is also secreted in response to ischeamia [3].
Localization (secreted) of IGFBP3 in plasma
19) Confidence 0.28 Published 2010 Journal Protein J Section Body Doc Link PMC2951508 Disease Relevance 0.61 Pain Relevance 0.05
IGF-I, IGFBP-1, and IGFBP-3 were measured at Endocrine Sciences (Tarzana, CA, USA).
Localization (measured) of IGFBP-3
20) Confidence 0.24 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 0.18 Pain Relevance 0.10

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