INT49371

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Context Info
Confidence 0.70
First Reported 1995
Last Reported 2010
Negated 3
Speculated 4
Reported most in Body
Documents 27
Total Number 31
Disease Relevance 23.13
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGFBP3) extracellular region (IGFBP3) nucleus (IGFBP3)
Anatomy Link Frequency
neurons 5
hypothalamus 2
plasma 2
gonadal 2
brain 2
IGFBP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 11 99.72 Very High Very High Very High
Fibrositis 14 99.28 Very High Very High Very High
cytokine 8 97.20 Very High Very High Very High
nMDA receptor 19 90.44 High High
medulla 38 89.92 High High
agonist 2 89.52 High High
Bioavailability 15 86.16 High High
Arthritis 7 83.60 Quite High
fibrosis 4 77.28 Quite High
Clonidine 5 75.48 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 95 99.98 Very High Very High Very High
Targeted Disruption 817 99.96 Very High Very High Very High
Adenoma 94 99.96 Very High Very High Very High
Reprotox - General 1 30 99.44 Very High Very High Very High
Fibromyalgia 13 99.28 Very High Very High Very High
Death 193 99.16 Very High Very High Very High
Adhesions 127 98.86 Very High Very High Very High
Stomach Cancer 2 98.56 Very High Very High Very High
Apoptosis 239 98.48 Very High Very High Very High
Hypoxia 40 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other studies have shown that elevated IGFBP-3 expression is associated with reduced risk of gastric cancer [3] and prostate cancer [37].
Positive_regulation (elevated) of Gene_expression (expression) of IGFBP-3 associated with reprotox - general 1 and stomach cancer
1) Confidence 0.70 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.08 Pain Relevance 0.03
Our data suggest that dexamethasone is unable to increase circulating IGF-I and IGFBP-3 levels in man in the absence of endogenous GH.
Neg (unable) Positive_regulation (increase) of Gene_expression (levels) of IGFBP-3 associated with dexamethasone
2) Confidence 0.63 Published 2001 Journal J. Endocrinol. Invest. Section Abstract Doc Link 11817711 Disease Relevance 0.07 Pain Relevance 0.28
It is apparent now that higher proliferative and reduced apoptotic nature of adhesion fibroblasts in human as reported earlier [5] could also derive from altered expression of hMet1-e, CSPG2, S100A10, CSPG2, IGFBP3, and the Bfl-1 that inhibits p53-induced apoptosis and is induced by cytokines TNF-?
Positive_regulation (derive) of Gene_expression (expression) of IGFBP3 in fibroblasts associated with apoptosis, adhesions and cytokine
3) Confidence 0.45 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 1.79 Pain Relevance 0.14
Our data suggest that dexamethasone is unable to increase circulating IGF-I and IGFBP-3 levels in man in the absence of endogenous GH.
Positive_regulation (circulating) of Gene_expression (levels) of IGFBP-3 associated with dexamethasone
4) Confidence 0.45 Published 2001 Journal J. Endocrinol. Invest. Section Abstract Doc Link 11817711 Disease Relevance 0.07 Pain Relevance 0.28
Together these data suggest that low levels of tissue IGFBP-3 may increase adenoma risk but is not likely to mediate the association between low apoptosis and increased risk of adenomas.
Neg (not) Spec (may) Positive_regulation (increase) of Gene_expression (levels) of tissue IGFBP-3 associated with adenoma and apoptosis
5) Confidence 0.44 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.73 Pain Relevance 0
Induction of IGFBP3 expression can occur in neurons and glial cells under various conditions, for example hypoxia [27], and this might also cause differences between humans and mice.
Positive_regulation (Induction) of Gene_expression (expression) of IGFBP3 in neurons associated with hypoxia
6) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.30 Pain Relevance 0
We next characterized whether overexpression of IGFBP3 and resulting effects on hypocretin transmission affect sleep and wakefulness by conducting sleep studies on hIGFBP3 transgenic mice and their littermates.
Spec (whether) Positive_regulation (overexpression) of Gene_expression (overexpression) of IGFBP3 associated with targeted disruption
7) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.79 Pain Relevance 0
Quantitative PCR analysis of human IGFBP3 transcripts in the hypothalamus of these models indicated that IGFBP3 is overexpressed approximately twice in hIGFBP3 transgenic animals and 10 times in hmutIGFBP3 transgenic animals, but is absent in IGFBP3 knockout animals (data not shown), validating these models.
Positive_regulation (overexpressed) of Neg (absent) Gene_expression (overexpressed) of IGFBP3 in hypothalamus associated with targeted disruption
8) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 1.48 Pain Relevance 0
Increased IGFBP3 expression (which was stable across the 24 hrs) was shown to have functional effects on sleep, as hIGFBP3 transgenic mice slept significantly more prior to light onset.
Positive_regulation (Increased) of Gene_expression (expression) of IGFBP3 associated with targeted disruption
9) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.51 Pain Relevance 0.04
Functional analysis indicated decreased hypocretin messenger RNA and peptide content, and increased sleep in transgenic mice overexpressing human IGFBP3, an effect possibly mediated through decreased hypocretin promotor activity in the presence of excessive IGFBP3.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of IGFBP3 associated with targeted disruption
10) Confidence 0.44 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2617764 Disease Relevance 0.73 Pain Relevance 0.03
To test the hypothesis that excessive IGFBP3 in hypocretin cells contributes to this cell death, we crossed Hcrt-ataxin-3 transgenic mice (animals with targeted cell death 2–4 weeks after birth) with transgenic mice overexpressing human IGFBP3 (hIGFBP3), but found no effects on the speed of hypocretin cell death.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of hIGFBP3 associated with targeted disruption and death
11) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 1.10 Pain Relevance 0.05
Finally, treatment with hGH (2 IU, s.c. daily), over 4 days, led to a clear-cut increase in plasma IGF-1 and IGFBP-3 levels in patients with FM.
Spec (clear) Positive_regulation (increase) of Gene_expression (levels) of IGFBP-3 in plasma associated with fibrositis
12) Confidence 0.33 Published 1999 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10487713 Disease Relevance 0.98 Pain Relevance 0.49
The lack of effects of IGFBP3 on cell death in this model might be due to the differences in circulating vs hypocretin cell specific IGFBP3 overexpression, or to lack of an IGFBP3 effect in the context of ataxin-induced cell degeneration, but is consistent with the notion that IGFBP3 may be proapoptotic only in specific circumstances, such as cancerous cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of IGFBP3 associated with death
13) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.97 Pain Relevance 0.04
The lack of effects of IGFBP3 on cell death in this model might be due to the differences in circulating vs hypocretin cell specific IGFBP3 overexpression, or to lack of an IGFBP3 effect in the context of ataxin-induced cell degeneration, but is consistent with the notion that IGFBP3 may be proapoptotic only in specific circumstances, such as cancerous cells.
Positive_regulation (circulating) of Gene_expression (overexpression) of IGFBP3 associated with death
14) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.98 Pain Relevance 0.04
Therefore we studied Hcrt KO mice and found that Igfbp3 expression was similar to that of WT mice (Fig. 1) indicating that loss of HCRT peptide itself did not induce changes in Igfbp3 expression.
Positive_regulation (similar) of Gene_expression (expression) of Igfbp3
15) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.22 Pain Relevance 0
IGFBP3 overexpression increases sleep at the end of the active period
Positive_regulation (overexpression) of Gene_expression (overexpression) of IGFBP3
16) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 1.00 Pain Relevance 0
To test the hypothesis that excessive IGFBP3 in hypocretin cells contributes to this cell death, we crossed Hcrt-ataxin-3 transgenic mice (animals with targeted cell death 2–4 weeks after birth) with transgenic mice overexpressing human IGFBP3 (hIGFBP3), but found no effects on the speed of hypocretin cell death.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of IGFBP3 associated with targeted disruption and death
17) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 1.09 Pain Relevance 0.05
IGFBP3 overexpression increases sleep at the end of the active period
Positive_regulation (increases) of Gene_expression (overexpression) of IGFBP3
18) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 1.00 Pain Relevance 0
To assess whether IGFBP3 overexpression could modulate cell death, hIGFBP3 transgenic mice were crossed with Hcrt-ataxin-3 transgenic mice known to develop hypocretin cell loss at 3–6 weeks of age.
Positive_regulation (overexpression) of Gene_expression (overexpression) of IGFBP3 associated with targeted disruption and death
19) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.95 Pain Relevance 0
We found that CSF levels of IGFBP3 were high, suggesting significant translocation from serum into brain extracellular fluid.
Positive_regulation (high) of Gene_expression (levels) of IGFBP3 in brain
20) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.27 Pain Relevance 0

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