INT49375

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Context Info
Confidence 0.62
First Reported 1995
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 4.54
Pain Relevance 5.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
spleen 8
neuronal 4
neurons 4
monocytes 2
B cell 2
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 29 100.00 Very High Very High Very High
adenocard 20 100.00 Very High Very High Very High
Enkephalin 9 99.82 Very High Very High Very High
narcan 6 99.82 Very High Very High Very High
Analgesic 3 99.82 Very High Very High Very High
cytokine 201 99.24 Very High Very High Very High
Inflammation 131 97.92 Very High Very High Very High
chemokine 42 97.84 Very High Very High Very High
Neuropeptide 3 95.68 Very High Very High Very High
Opioid 6 94.96 High High
Disease Link Frequency Relevance Heat
Hypersensitivity 4 99.40 Very High Very High Very High
Shock 11 97.96 Very High Very High Very High
INFLAMMATION 129 97.92 Very High Very High Very High
Fever 32 96.64 Very High Very High Very High
Influenza Virus Infection 92 94.00 High High
Cancer 209 93.44 High High
Adhesions 15 89.52 High High
Pneumonia 21 87.08 High High
Increased Venous Pressure Under Development 8 84.52 Quite High
Neutropenia 6 83.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As parameter for immune function, modulation of interleukin-6 (IL-6) release by the spleen cells brought about by electrical stimulation was investigated.
Spec (investigated) Regulation (modulation) of Localization (release) of interleukin-6 in spleen
1) Confidence 0.62 Published 1995 Journal J. Neuroimmunol. Section Abstract Doc Link 7560012 Disease Relevance 0 Pain Relevance 0.16
To study aspects of this neuronal-immune communication, a recently developed tissue slice method was used to study the effects of adrenergic and opioidergic transmitters on interleukin 6 (IL-6) secretion in the spleen.
Regulation (effects) of Localization (secretion) of interleukin 6 in neuronal
2) Confidence 0.62 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084435 Disease Relevance 0 Pain Relevance 0.30
Neuronal regulation of interleukin 6 secretion in murine spleen: adrenergic and opioidergic control.
Regulation (regulation) of Localization (secretion) of interleukin 6 in spleen associated with analgesic
3) Confidence 0.62 Published 1997 Journal J. Neurochem. Section Title Doc Link 9084435 Disease Relevance 0 Pain Relevance 0.60
Immunoregulation of IL-6 secretion by endogenous and exogenous adenosine and by exogenous purinergic agonists in splenic tissue slices.
Regulation (Immunoregulation) of Localization (secretion) of IL-6 associated with adenocard and agonist
4) Confidence 0.61 Published 2002 Journal J. Neuroimmunol. Section Title Doc Link 11960643 Disease Relevance 0 Pain Relevance 0.72
As parameter for immune function, modulation of interleukin-6 (IL-6) release by the spleen cells brought about by electrical stimulation was investigated.
Spec (investigated) Regulation (modulation) of Localization (release) of IL-6 in spleen
5) Confidence 0.45 Published 1995 Journal J. Neuroimmunol. Section Abstract Doc Link 7560012 Disease Relevance 0 Pain Relevance 0.16
To study aspects of this neuronal-immune communication, a recently developed tissue slice method was used to study the effects of adrenergic and opioidergic transmitters on interleukin 6 (IL-6) secretion in the spleen.
Regulation (effects) of Localization (secretion) of IL-6 in neuronal
6) Confidence 0.45 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084435 Disease Relevance 0 Pain Relevance 0.30
More importantly, direct application of IL-6 to cultured neurons resulted in a significant increase in Nox-2 expression and superoxide production which was fully blocked by the NF?
Regulation (resulted) of Localization (application) of IL-6 in neurons
7) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.16 Pain Relevance 0.13
More importantly, direct application of IL-6 to cultured neurons resulted in a significant increase in Nox-2 expression and superoxide production which was fully blocked by the NF?
Regulation (direct) of Localization (application) of IL-6 in neurons
8) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.16 Pain Relevance 0.13
In this study, we describe the role of exogenous and endogenous adenosine and exogenous P2X(1) and P2Y(1) agonists for spontaneous splenic IL-6 secretion from spleen slices.
Regulation (role) of Localization (secretion) of IL-6 in spleen associated with adenocard and agonist
9) Confidence 0.45 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960643 Disease Relevance 0 Pain Relevance 0.62
further release of IL-6 only for monocytes isolated within the first 12 hours from
Regulation (isolated) of Localization (release) of IL-6 in monocytes
10) Confidence 0.36 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276911 Disease Relevance 0.67 Pain Relevance 0.10
Effect of p50 deficiency on LPS-induced neutrophil recruitment in the absence of IL-6
Regulation (recruitment) of Neg (absence) Localization (absence) of IL-6 in neutrophil
11) Confidence 0.27 Published 2004 Journal BMC Immunol Section Body Doc Link PMC449706 Disease Relevance 0.88 Pain Relevance 0.34
To confirm the importance of huMSC-secreted EGF and IL-6 on Skov-3 cell proliferation, we co-cultured huMSC and rLuc/RFP labeled Skov-3 in vitro and immunoprecipitated (IP) EGF and/or IL-6 out of solution (individually and in combination).
Regulation (importance) of Localization (secreted) of IL-6
12) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.34 Pain Relevance 0
On the other hand, Rx had a more effective inhibitory effect than Rosiglitazone on the secretion of MCP-1 and IL-6 (figure 3a, b).
Regulation (effect) of Localization (secretion) of IL-6
13) Confidence 0.19 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 0.31 Pain Relevance 0.24
Furthermore, the release of MCP-1 and IL-6 is highly calcium-dependent.
Regulation (dependent) of Localization (release) of IL-6
14) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.82
ATs modulate the secretion of IL-6, and TNF?
Regulation (modulate) of Localization (secretion) of IL-6
15) Confidence 0.11 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.53 Pain Relevance 0.08
ATs modulate the secretion of IL-6, and TNF?
Regulation (modulate) of Localization (secretion) of IL-6
16) Confidence 0.08 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.53 Pain Relevance 0.08
induction by C- and D-type CpG ODNs in human pDCs and B cells is markedly reduced by stimulation of TLR7, without affecting IL-6 secretion or B cell proliferation [204–206].
Neg (without) Regulation (affecting) of Localization (secretion) of IL-6 in B cell
17) Confidence 0.04 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.76 Pain Relevance 0.22
Activation of muscular IL-6 release depends also on glycogen levels [184], as well as on the interplay of Ca2+ [185].
Regulation (depends) of Localization (release) of IL-6
18) Confidence 0.02 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1820789 Disease Relevance 0.20 Pain Relevance 0.10

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