INT49376

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 37
Total Number 37
Disease Relevance 12.66
Pain Relevance 14.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
macrophages 8
leukocyte 4
adipose tissue 3
adipocytes 3
blood 2
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 394 100.00 Very High Very High Very High
cytokine 341 100.00 Very High Very High Very High
chemokine 29 100.00 Very High Very High Very High
agonist 95 99.98 Very High Very High Very High
qutenza 20 99.98 Very High Very High Very High
Morphine 9 99.98 Very High Very High Very High
cva 7 99.80 Very High Very High Very High
Enkephalin 18 99.76 Very High Very High Very High
adenocard 198 99.68 Very High Very High Very High
Neurotransmitter 13 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 457 100.00 Very High Very High Very High
Necrosis 16 100.00 Very High Very High Very High
Cancer 32 99.92 Very High Very High Very High
Hemorrhage 7 99.80 Very High Very High Very High
Sepsis 478 99.68 Very High Very High Very High
Arthritis 24 99.36 Very High Very High Very High
Obesity 77 98.80 Very High Very High Very High
Pneumonia 40 98.56 Very High Very High Very High
Ocular & Orbital Inflammation 11 97.56 Very High Very High Very High
Schizophrenia 2 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Electrical stimulation substantially reduced IL-6 secretion at 6 h (control: 143.4 +/- 14.3 vs. electrical: 71.3 +/- 7.9 pg/ml/10(6) leukocytes, P = 0.0001).
Negative_regulation (reduced) of Localization (secretion) of IL-6 in leukocytes
1) Confidence 0.59 Published 1995 Journal J. Neuroimmunol. Section Abstract Doc Link 7560012 Disease Relevance 0 Pain Relevance 0.17
Electrical stimulation of spleen slices inhibited IL-6 secretion (100.0 +/- 4.3 vs. 56.7 +/- 4.6% of control values; p < 0.001).
Negative_regulation (inhibited) of Localization (secretion) of IL-6 in spleen
2) Confidence 0.59 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084435 Disease Relevance 0 Pain Relevance 0.44
Electrical inhibition of IL-6 secretion was attenuated by phentolamine (10(-7) M; p = 0.0345), by naloxone (10(-6) M; p = 0.0046), by cyprodime (10(-8) M; p = 0.0014), and by the combination of cyprodime (10(-7) M) plus phentolamine (10(-8) M; p < 0.0001).
Negative_regulation (inhibition) of Localization (secretion) of IL-6 associated with narcan
3) Confidence 0.59 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084435 Disease Relevance 0 Pain Relevance 0.42
We conclude from the complementary studies that the inhibition of IL-6 secretion induced by electrical pulses was mostly mediated by alpha-adrenergic and mu-opioidergic endogenous transmitters.
Negative_regulation (inhibition) of Localization (secretion) of IL-6
4) Confidence 0.59 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084435 Disease Relevance 0 Pain Relevance 0.36
The alpha 1-adrenergic agonist methoxamine (10(-8) M) also inhibited IL-6 secretion (100.0 +/- 4.8 vs. 71.5 +/- 3.8%; p < 0.001).
Negative_regulation (inhibited) of Localization (secretion) of IL-6 associated with agonist
5) Confidence 0.59 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084435 Disease Relevance 0 Pain Relevance 0.43
The alpha 2-adrenergic agonist p-aminoclonidine (10(-7) M) inhibited IL-6 secretion (control vs. p-aminoclonidine, 100.0 +/- 4.76 vs. 59.3 +/- 6.6% of control values; p < 0.001).
Negative_regulation (inhibited) of Localization (secretion) of IL-6 associated with agonist
6) Confidence 0.59 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084435 Disease Relevance 0 Pain Relevance 0.33
Electrical field stimulation markedly reduced IL-6 secretion, which was attenuated by the A1 antagonist DPCPX but not by the A2 antagonist 8-(3-Chlorostyryl)caffeine.
Negative_regulation (reduced) of Localization (secretion) of IL-6 associated with antagonist
7) Confidence 0.58 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960643 Disease Relevance 0 Pain Relevance 0.78
Furthermore, adenosine (at 5 x 10(-8), 10(-7), 5 x 10(-7) M) inhibited IL-6 secretion via A1 adenosine receptors, whereas an A2(A) adenosine receptor agonist increased IL-6 secretion in the presence of 10(-7) M cortisol.
Negative_regulation (inhibited) of Localization (secretion) of IL-6 associated with adenocard and agonist
8) Confidence 0.58 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960643 Disease Relevance 0 Pain Relevance 0.78
Thus, via A1 adenosine receptors, adenosine was found to be a strong inhibitor of splenic IL-6 secretion.
Negative_regulation (inhibitor) of Localization (secretion) of IL-6 associated with adenocard
9) Confidence 0.58 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960643 Disease Relevance 0 Pain Relevance 0.74
Hemorrhage markedly decreased the ability of pMphi and sMphi to release IL-1 and IL-6.
Negative_regulation (decreased) of Localization (release) of IL-6 associated with cva
10) Confidence 0.49 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8955229 Disease Relevance 0.80 Pain Relevance 0.39
The attenuation of leukocyte recruitment might lead to the reduction of secretion of IL-6 and MCP-1.
Negative_regulation (reduction) of Localization (secretion) of IL-6 in leukocyte
11) Confidence 0.47 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 0.85 Pain Relevance 0.26
A significant reduction of IL-6 release occurred in response to all PM, except for MSH and diesel exhaust.
Negative_regulation (reduction) of Localization (release) of IL-6
12) Confidence 0.45 Published 2002 Journal Inhal Toxicol Section Abstract Doc Link 12122578 Disease Relevance 0.24 Pain Relevance 0.36
Although both CPZ and amiloride significantly reduced IL-6 release for all PM, the degree of inhibition was less for the PM-exposed DRG relative to BEAS-2B cells.
Negative_regulation (reduced) of Localization (release) of IL-6 in BEAS-2B
13) Confidence 0.45 Published 2002 Journal Inhal Toxicol Section Abstract Doc Link 12122578 Disease Relevance 0.20 Pain Relevance 0.30
The endogenous opioids beta-endorphin (10(-10) M), methionine-enkephalin (10(-9) M), and leucine-enkephalin (10(-9) M) inhibited IL-6 secretion as well (p = 0.0051, p = 0.0337, and p = 0.0226, respectively).
Negative_regulation (inhibited) of Localization (secretion) of IL-6 associated with endogenous opioid and enkephalin
14) Confidence 0.43 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084435 Disease Relevance 0 Pain Relevance 0.45
The P2X(1) agonist beta,gamma-methylene ATP inhibited IL-6 secretion at 10(-5) M, whereas the P2Y(1) agonist 2-methylthio ATP increased IL-6 secretion at 10(-6) to 10(-8) M.
Negative_regulation (inhibited) of Localization (secretion) of IL-6 associated with agonist
15) Confidence 0.43 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960643 Disease Relevance 0 Pain Relevance 0.66
Electrical field stimulation markedly reduced IL-6 secretion, which was attenuated by the A1 antagonist DPCPX but not by the A2 antagonist 8-(3-Chlorostyryl)caffeine.
Negative_regulation (attenuated) of Localization (secretion) of IL-6 associated with antagonist
16) Confidence 0.43 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960643 Disease Relevance 0 Pain Relevance 0.78
The IL-6 protein content in adipose tissue has been negatively correlated with insulin-stimulated glucose disposal, and a chronic elevation of IL-6 is not desirable because it may compromise insulin sensitivity (5,19).
Neg (not) Negative_regulation (desirable) of Localization (elevation) of IL-6 in adipose tissue associated with obesity
17) Confidence 0.35 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.58 Pain Relevance 0
Capsaicin inhibited the expressions of IL-6 and MCP-1 mRNAs and protein release from the adipose tissues and adipocytes of obese mice, whereas it enhanced the expression of the adiponectin gene and protein.
Negative_regulation (inhibited) of Localization (release) of IL-6 in adipocytes associated with qutenza and obesity
18) Confidence 0.33 Published 2007 Journal FEBS Lett. Section Abstract Doc Link 17719033 Disease Relevance 1.23 Pain Relevance 0.67
Macrophage cultures from CLP animals incubated with either epinephrine or IL-10 for 2 h had significantly reduced TNF-alpha and IL-6 release in response to LPS.
Negative_regulation (reduced) of Localization (release) of IL-6 in Macrophage
19) Confidence 0.28 Published 2004 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 15151906 Disease Relevance 0.30 Pain Relevance 0.34
In contrast, morphine reduction of splenic and thymic cell number and mitogen-induced proliferation were unaffected in MOR-KO mice, as was morphine inhibition of IL-1 and IL-6 secretion by macrophages.
Negative_regulation (inhibition) of Localization (secretion) of IL-6 in macrophages associated with morphine
20) Confidence 0.26 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9795212 Disease Relevance 0.16 Pain Relevance 1.00

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