INT49377

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Context Info
Confidence 0.49
First Reported 1995
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 9.84
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Scd1) endoplasmic reticulum (Scd1) lipid metabolic process (Scd1)
Anatomy Link Frequency
colon 2
hepatocytes 1
pulmonary artery 1
Scd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 119 99.56 Very High Very High Very High
Pain 3 93.76 High High
Crohn's disease 20 89.08 High High
antagonist 31 83.44 Quite High
Enkephalin 9 75.00 Quite High
fibrosis 11 68.40 Quite High
Opioid 1 67.76 Quite High
aspirin 4 67.60 Quite High
cytokine 14 51.12 Quite High
agonist 317 50.00 Quite Low
Disease Link Frequency Relevance Heat
Sickle Cell Anemia 27 100.00 Very High Very High Very High
Obesity 362 99.72 Very High Very High Very High
INFLAMMATION 124 99.56 Very High Very High Very High
Apoptosis 22 99.20 Very High Very High Very High
Colitis 4 98.94 Very High Very High Very High
Metabolic Disorder 101 97.92 Very High Very High Very High
Injury 14 95.16 Very High Very High Very High
Pain 3 93.76 High High
Congenital Anomalies 22 91.12 High High
Fibrosis 8 89.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LCMS metabolite profiling of serum from mice treated with dextran sulphate sodium (DSS) to induce colitis showed that colon inflammation was increased by DSS-inhibition of stearoyl-CoA desaturase 1 (SCD1)-mediated oleic acid biogenesis [10].
Negative_regulation (inhibition) of SCD1 in colon associated with colitis and inflammation
1) Confidence 0.49 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005964 Disease Relevance 1.13 Pain Relevance 0.54
LCMS metabolite profiling of serum from mice treated with dextran sulphate sodium (DSS) to induce colitis showed that colon inflammation was increased by DSS-inhibition of stearoyl-CoA desaturase 1 (SCD1)-mediated oleic acid biogenesis [10].
Negative_regulation (inhibition) of stearoyl-CoA desaturase 1 in colon associated with colitis and inflammation
2) Confidence 0.49 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005964 Disease Relevance 1.12 Pain Relevance 0.54
Specifically, the fasting-mediated down-regulation of SREBP-1c and its target gene stearoyl-CoA desaturase (SCD1), was abolished in PGC-1??
Negative_regulation (ted down-regula) of gene stearoyl-CoA desaturase
3) Confidence 0.31 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064854 Disease Relevance 0.09 Pain Relevance 0
Furthermore, inhibition of SCD-1 sensitized hepatocytes to SFA-induced apoptosis, and mice fed with a high-fat diet showed increased SCD-1 expression and hepatic accumulation of MUFA.
Negative_regulation (inhibition) of SCD-1 in hepatocytes associated with apoptosis
4) Confidence 0.30 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 1.06 Pain Relevance 0.03
Compared to wild type ob/ob mice, triglyceride content as well as mRNA levels of lipogenic genes, such as fatty acid synthase (Fasn), acetyl CoA carboxylase (Acc), and stearoyl CoA desaturase 1 (Scd1), were strongly decreased in corresponding PPAR?
Negative_regulation (decreased) of Scd1 associated with obesity
5) Confidence 0.18 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.54 Pain Relevance 0
Compared to wild type ob/ob mice, triglyceride content as well as mRNA levels of lipogenic genes, such as fatty acid synthase (Fasn), acetyl CoA carboxylase (Acc), and stearoyl CoA desaturase 1 (Scd1), were strongly decreased in corresponding PPAR?
Negative_regulation (decreased) of CoA desaturase 1 associated with obesity
6) Confidence 0.16 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.55 Pain Relevance 0
An SCD-1 inhibitor that reduces SCD-1 activity may serve as a therapeutic
Negative_regulation (inhibitor) of SCD-1
7) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0.95 Pain Relevance 0.03
SCD-1 deficiency in ob/ob mice ameliorates obesity and completely corrects the excessive hepatic lipid
Negative_regulation (deficiency) of SCD-1 associated with obesity
8) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 1.20 Pain Relevance 0
An SCD-1 inhibitor that reduces SCD-1 activity may serve as a therapeutic
Negative_regulation (inhibitor) of SCD-1
9) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0.96 Pain Relevance 0.03
of SCD-1 inhibitor.
Negative_regulation (inhibitor) of SCD-1
10) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0.99 Pain Relevance 0.03
Treatment with arginine supplementation was also shown to decrease pulmonary artery pressures in ten SCD patients [48]; however, the number of pills and dosing schedule required for an effect limit the use of arginine in clinical practice.
Negative_regulation (decrease) of SCD in pulmonary artery associated with sickle cell anemia
11) Confidence 0.11 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948405 Disease Relevance 1.24 Pain Relevance 0.18
The inhibitory effect of mAb and pAb was specific since it was not produced by non-immune mouse IgG or several non-immune rabbit sera and was completely reversed by 1 microM of the synthetic peptide [Tyr63](syn 63-70) synenkephalin.
Negative_regulation (effect) of mAb
12) Confidence 0.00 Published 1995 Journal J. Neuroimmunol. Section Abstract Doc Link 7560016 Disease Relevance 0 Pain Relevance 0.50

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