INT49379

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Context Info
Confidence 0.77
First Reported 1995
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 26
Total Number 29
Disease Relevance 13.07
Pain Relevance 16.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP12) extracellular region (MMP12) proteinaceous extracellular matrix (MMP12)
Anatomy Link Frequency
smooth muscle cells 4
macrophages 3
lymphocytes 1
MMP12 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 3767 100.00 Very High Very High Very High
Enkephalin 9 99.96 Very High Very High Very High
cytokine 485 99.80 Very High Very High Very High
Inflammation 600 99.40 Very High Very High Very High
Inflammatory stimuli 24 98.16 Very High Very High Very High
corticosteroid 192 93.76 High High
dexamethasone 168 92.56 High High
anesthesia 3 85.12 High High
cINOD 24 84.64 Quite High
Inflammatory response 6 79.52 Quite High
Disease Link Frequency Relevance Heat
Pulmonary Disease 596 99.60 Very High Very High Very High
INFLAMMATION 702 99.40 Very High Very High Very High
Breast Cancer 20 98.24 Very High Very High Very High
Disease 56 97.32 Very High Very High Very High
Emphysema 84 96.12 Very High Very High Very High
Cough 96 94.76 High High
Nicotine Addiction 370 93.88 High High
Asthma 288 93.36 High High
Necrosis 72 90.60 High High
Cancer 95 90.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To analyse the secretion of MMP-12, conditioned medium (400 ?
Spec (analyse) Localization (secretion) of MMP-12 associated with metalloproteinase
1) Confidence 0.77 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0 Pain Relevance 0.12
enhanced MMP-12 release from ASMC.
Localization (release) of MMP-12 associated with metalloproteinase
2) Confidence 0.77 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.56 Pain Relevance 0.63
Overall, these data imply that MMP-12 release from ASMC is under the control of select pro-inflammatory stimuli and is regulated differently between human and murine cells.
Localization (release) of MMP-12 associated with metalloproteinase and inflammatory stimuli
3) Confidence 0.72 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.10 Pain Relevance 0.72
Abundant VEGF and MMP12 were secreted from both tumoural and non-tumoural cells, and these cytokines promote macrophage migration and angiogenesis.
Localization (secreted) of MMP12 in macrophage associated with cytokine
4) Confidence 0.71 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2936386 Disease Relevance 0.70 Pain Relevance 0.14
In cultured primary ASMC, we have also shown that MMP-12 mRNA and protein expression and secretion were regulated by the inflammatory cytokine, IL-1?.
Localization (secretion) of MMP-12 mRNA associated with inflammation, metalloproteinase and cytokine
5) Confidence 0.68 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.69 Pain Relevance 0.73
stimulates a significant enhancement in MMP-12 gene expression, protein production and enzyme secretion, which is mediated by mechanisms involving ERK, JNK, PI3-K and AP-1 signaling pathways.
Localization (secretion) of MMP-12 gene associated with metalloproteinase
6) Confidence 0.68 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 1.25 Pain Relevance 1.17
MMP-12 protein expression and secretion from cultured primary airway smooth muscle cells was further analysed by Western blot.
Localization (secretion) of MMP-12 protein in smooth muscle cells associated with metalloproteinase
7) Confidence 0.68 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1363355 Disease Relevance 0.48 Pain Relevance 0.50
Secretion of MMP-12 protein by ASMC and enhancement by IL-1?
Localization (Secretion) of MMP-12 protein associated with metalloproteinase
8) Confidence 0.68 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0 Pain Relevance 0.74
Actually, we did not evaluate the activity of macrophages in this study, thus we were not able to investigate the ratio of MMP-12 release and activated macrophages in this study.
Localization (release) of MMP-12 in macrophages associated with metalloproteinase
9) Confidence 0.68 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 2.51 Pain Relevance 0.54
enhanced MMP-12 secretion and activity of ASMC in a time- and concentration-dependent manner, with an up to 10-fold increase to control levels, as determined by gelatin zymography.
Localization (secretion) of MMP-12 associated with metalloproteinase
10) Confidence 0.68 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.54 Pain Relevance 0.60
Our data are similar to previous studies on MMP-12 release by macrophages [17,18].
Localization (release) of MMP-12 in macrophages associated with metalloproteinase
11) Confidence 0.68 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.33 Pain Relevance 0.53
Western blot analysis of MMP-12 secretion by airway smooth muscle cells
Localization (secretion) of MMP-12 in smooth muscle cells associated with metalloproteinase
12) Confidence 0.68 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.06 Pain Relevance 0.62
Unstimulated ASMC secreted a detectable active form of MMP-12, with a time-dependent enhancement of the secretion after exposing cells with 10 ng/ml IL-1?
Localization (secreted) of MMP-12 associated with metalloproteinase
13) Confidence 0.68 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0 Pain Relevance 0.79
The results of MMP-12 secretion analysed by Western blot was consistent with the data obtained by gelatin zymography and confirmed that ASMC secreted the 45 kDa active form of MMP-12 which was up-regulated by inflammatory cytokines, IL-1?
Spec (analysed) Localization (secretion) of MMP-12 associated with inflammation, metalloproteinase and cytokine
14) Confidence 0.68 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.19 Pain Relevance 0.62
We also performed Western blot analysis to determine MMP-12 secretion by using a specific MMP-12 antibody (Figure 9).
Spec (determine) Localization (secretion) of MMP-12 associated with metalloproteinase
15) Confidence 0.68 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.07 Pain Relevance 0.60
Though, most studies investigating MMP-12 were performed using animal models and exact role of MMP-12 in human COPD inflammation is not fully understood.
Localization (role) of MMP-12 associated with pulmonary disease, inflammation and metalloproteinase
16) Confidence 0.63 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 2.28 Pain Relevance 0.57
The results of MMP-12 secretion analysed by Western blot was consistent with the data obtained by gelatin zymography and confirmed that ASMC secreted the 45 kDa active form of MMP-12 which was up-regulated by inflammatory cytokines, IL-1?
Localization (secreted) of MMP-12 associated with inflammation, metalloproteinase and cytokine
17) Confidence 0.63 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.28 Pain Relevance 0.60
We investigated whether human airway smooth muscle cells could express and secrete MMP-12, thereby participating in the pathogenesis of airway inflammatory diseases.


Localization (secrete) of MMP-12 in smooth muscle cells associated with inflammation, metalloproteinase and disease
18) Confidence 0.59 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1363355 Disease Relevance 0.29 Pain Relevance 0.42
MMP-12 protein localization in bronchial tissue sections was detected by immunohistochemistry.
Localization (localization) of MMP-12 protein associated with metalloproteinase
19) Confidence 0.59 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1363355 Disease Relevance 0.50 Pain Relevance 0.56
Therefore, we examined whether these cytokines affected MMP-12 secretion mediated through regulation of c-Jun activity in ASMC.
Localization (secretion) of MMP-12 associated with metalloproteinase and cytokine
20) Confidence 0.59 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.07 Pain Relevance 0.73

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