INT4938

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Context Info
Confidence 0.65
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.73
Pain Relevance 5.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnc) extracellular region (Tnc) proteinaceous extracellular matrix (Tnc)
molecular_function (Tnc)
Anatomy Link Frequency
trigeminal ganglia 1
TNC 1
nucleus 1
Tnc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 19 100.00 Very High Very High Very High
Calcitonin gene-related peptide 30 99.98 Very High Very High Very High
substance P 16 99.98 Very High Very High Very High
cytokine 5 99.96 Very High Very High Very High
Morphine 16 99.62 Very High Very High Very High
opioid receptor 12 99.46 Very High Very High Very High
Inflammation 14 99.16 Very High Very High Very High
agonist 6 98.68 Very High Very High Very High
Enkephalin 6 97.92 Very High Very High Very High
headache 2 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 19 100.00 Very High Very High Very High
INFLAMMATION 23 99.16 Very High Very High Very High
Headache 4 97.44 Very High Very High Very High
Pain 12 95.76 Very High Very High Very High
Nociception 14 81.88 Quite High
Temporomandibular Joint Disorders 9 50.56 Quite High
Nervous System Injury 1 32.96 Quite Low
Chronic Disease 3 26.36 Quite Low
Injury 1 14.16 Low Low
Temporomandibular Joint Syndrome 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also the effect of the BK(Ca) channel blocker iberiotoxin and the BK(Ca) channel opener NS11021 on CGRP release from isolated TG and TNC was investigated.
Localization (release) of TNC associated with trigeminal ganglion and calcitonin gene-related peptide
1) Confidence 0.65 Published 2010 Journal Neuroscience Section Abstract Doc Link 20211697 Disease Relevance 1.00 Pain Relevance 0.98
These findings indicate that delta-opioid receptor-mediated inhibition of SP release from TNC can be achieved by nanomolar concentrations of selective delta-opioid receptor agonists.
Localization (release) of TNC associated with agonist, opioid receptor and substance p
2) Confidence 0.53 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1282103 Disease Relevance 0 Pain Relevance 1.80
We examined the effects of a 30 min NO-donor infusion on CGRP release in jugular vein blood and c-fos LI within TNC of the rat.
Localization (release) of TNC in TNC
3) Confidence 0.52 Published 2005 Journal Cephalalgia Section Abstract Doc Link 15689199 Disease Relevance 0.10 Pain Relevance 0.51
In the present study, we have examined the effect of nanomolar concentrations of [D-Pen2,D-Pen5]enkephalin (DPDPE, delta-opioid receptor agonist) and low micromolar of concentrations morphine on K(+)-evoked SP release from rat trigeminal nucleus caudalis (TNC) slices.
Localization (release) of TNC in nucleus associated with agonist, opioid receptor, enkephalin, substance p and morphine
4) Confidence 0.47 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1282103 Disease Relevance 0 Pain Relevance 1.36
CGRP is known to stimulate glial cells in the trigeminal ganglia and TNC to release cytokines and other inflammatory molecules leading to a lower threshold of activation and contributing to persistent pain [19-21].
Localization (release) of TNC in trigeminal ganglia associated with pain, inflammation, lasting pain, cytokine and calcitonin gene-related peptide
5) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.63 Pain Relevance 0.99

General Comments

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