INT49396

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 29
Total Number 31
Disease Relevance 16.39
Pain Relevance 11.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
plasma 7
coronary artery 6
spikes 4
brain 4
pituitary 4
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 139 100.00 Very High Very High Very High
Nerve growth factor 87 100.00 Very High Very High Very High
antagonist 126 99.98 Very High Very High Very High
ketamine 32 99.98 Very High Very High Very High
Pain 20 99.98 Very High Very High Very High
Morphine 16 99.84 Very High Very High Very High
rheumatoid arthritis 28 99.56 Very High Very High Very High
withdrawal 10 99.52 Very High Very High Very High
fluoxetine 11 99.50 Very High Very High Very High
anesthesia 16 99.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 147 100.00 Very High Very High Very High
Pain 16 99.98 Very High Very High Very High
Targeted Disruption 66 99.84 Very High Very High Very High
Hypothermia 18 99.72 Very High Very High Very High
Rheumatoid Arthritis 52 99.56 Very High Very High Very High
Brain Injury 4 99.44 Very High Very High Very High
Infection 14 99.18 Very High Very High Very High
Stress 150 98.40 Very High Very High Very High
Arthritis 57 98.00 Very High Very High Very High
Pressure And Volume Under Development 18 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with a ganglionic blocker, chlorisondamine (0.5 mg/kg i.p.), also blocked the elevation of IL-6 by morphine, suggesting a role of the autonomic nervous system.
Negative_regulation (blocked) of Positive_regulation (elevation) of IL-6 in autonomic nervous system associated with morphine
1) Confidence 0.59 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11752119 Disease Relevance 0 Pain Relevance 1.02
Beta-adrenoceptor antagonists suppress elevation in body temperature and increase in plasma IL-6 in rats exposed to open field.
Negative_regulation (suppress) of in body Positive_regulation (increase) of IL-6 in plasma associated with antagonist
2) Confidence 0.59 Published 1996 Journal Neuroendocrinology Section Title Doc Link 8738584 Disease Relevance 0.09 Pain Relevance 0.19
Although the suppression by morphine of lymphocyte proliferation appeared to be largely independent of stimulation of the hypothalamic-pituitary-adrenal axis, the elevation of IL-6 was completely abolished in adrenalectomized animals.
Negative_regulation (abolished) of Positive_regulation (elevation) of IL-6 in pituitary associated with morphine
3) Confidence 0.58 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11268406 Disease Relevance 0 Pain Relevance 0.69
Implications: In this randomized, double-blind, prospective study of patients during and after coronary artery bypass surgery, we examined whether small-dose ketamine added to general anesthesia before cardiopulmonary bypass suppresses the increase of the serum interleukin-6 (IL-6) concentration.
Spec (whether) Negative_regulation (suppresses) of Spec (whether) Positive_regulation (increase) of IL-6 in coronary artery associated with anesthesia and ketamine
4) Confidence 0.58 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9706914 Disease Relevance 0 Pain Relevance 0.45
Ketamine suppresses the increase of serum IL-6 during and after coronary artery bypass surgery.
Negative_regulation (suppresses) of Positive_regulation (increase) of IL-6 in coronary artery associated with ketamine
5) Confidence 0.58 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9706914 Disease Relevance 0 Pain Relevance 0.42
A single dose of ketamine 0.25 mg/kg administered before CPB suppresses the increase of serum IL-6 during and after CABG.
Negative_regulation (suppresses) of Positive_regulation (increase) of IL-6 associated with ketamine
6) Confidence 0.58 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9706914 Disease Relevance 0.05 Pain Relevance 0.54
High levels of plasma interleukin-6 (IL-6) were reduced to the normal range.
Negative_regulation (reduced) of Positive_regulation (levels) of IL-6 in plasma
7) Confidence 0.58 Published 1995 Journal J. Dermatol. Section Abstract Doc Link 7560444 Disease Relevance 0.61 Pain Relevance 0.10
BVA treatment also reduced the increase in serum interleukin-6 caused by RA induction to levels observed in non-arthritic animals.
Negative_regulation (reduced) of Positive_regulation (increase) of interleukin-6 associated with rheumatoid arthritis and arthritis
8) Confidence 0.53 Published 2002 Journal Life Sci. Section Abstract Doc Link 12031688 Disease Relevance 1.47 Pain Relevance 0.81
Abnormal EEG activities were observed in all infected rats under anesthesia, including high voltage EEG burst amplitude and increased EEG spikes in the early phase (8 h-day 2) of infection, and these increases at the early phase were in parallel with a significant increase level of interleukin-6 (IL-6) in the serum.
Negative_regulation (were) of Positive_regulation (increase) of IL-6 in spikes associated with anesthesia and infection
9) Confidence 0.43 Published 2010 Journal Neuroscience Section Abstract Doc Link 19892004 Disease Relevance 1.47 Pain Relevance 0.18
Nadolol blocked the open field-induced rise in plasma IL-6 only when injected i.c.v. but no i.p.
Negative_regulation (blocked) of Positive_regulation (field-induced) of IL-6 in plasma
10) Confidence 0.43 Published 1996 Journal Neuroendocrinology Section Abstract Doc Link 8738584 Disease Relevance 0 Pain Relevance 0.11
The rhIL-6 (30 ng)-induced reduction of the paw-withdrawal latency was completely blocked by the co-injection of either Na salicylate (30 ng, LCV) or alpha-melanocyte stimulating hormone (30 ng, LCV), an anti-cytokine substance.
Negative_regulation (reduction) of Positive_regulation (-induced) of rhIL-6 in melanocyte associated with hypersensitivity vasculitis, withdrawal and cytokine
11) Confidence 0.42 Published 1995 Journal Brain Res. Section Abstract Doc Link 8548295 Disease Relevance 0.64 Pain Relevance 0.52
High levels of plasma interleukin-6 (IL-6) were reduced to the normal range.
Negative_regulation (reduced) of Positive_regulation (levels) of interleukin-6 in plasma
12) Confidence 0.42 Published 1995 Journal J. Dermatol. Section Abstract Doc Link 7560444 Disease Relevance 0.61 Pain Relevance 0.10
Implications: In this randomized, double-blind, prospective study of patients during and after coronary artery bypass surgery, we examined whether small-dose ketamine added to general anesthesia before cardiopulmonary bypass suppresses the increase of the serum interleukin-6 (IL-6) concentration.
Spec (whether) Negative_regulation (suppresses) of Spec (whether) Positive_regulation (increase) of interleukin-6 in coronary artery associated with anesthesia and ketamine
13) Confidence 0.42 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9706914 Disease Relevance 0 Pain Relevance 0.44
The patients with ongoing pain displayed significantly elevated IL-6 levels and an attenuated elevation of cortisol secretion after awakening compared to the two other groups.
Negative_regulation (displayed) of Positive_regulation (elevated) of IL-6 associated with pain
14) Confidence 0.42 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9453216 Disease Relevance 0.85 Pain Relevance 0.49
The patients with ongoing pain displayed significantly elevated IL-6 levels and an attenuated elevation of cortisol secretion after awakening compared to the two other groups.
Negative_regulation (displayed) of Positive_regulation (elevated) of IL-6 associated with pain
15) Confidence 0.42 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9453216 Disease Relevance 0.85 Pain Relevance 0.49
Serum IL-1beta and IL-6 levels were significantly higher at 2, 4, and 8 hours after LPS injection and were equally suppressed in the laparotomy and laparoscopic groups (P < 0.05).
Negative_regulation (suppressed) of Positive_regulation (levels) of IL-6
16) Confidence 0.40 Published 2005 Journal Surg Laparosc Endosc Percutan Tech Section Abstract Doc Link 15956894 Disease Relevance 0.47 Pain Relevance 0.21
Abnormal EEG activities were observed in all infected rats under anesthesia, including high voltage EEG burst amplitude and increased EEG spikes in the early phase (8 h-day 2) of infection, and these increases at the early phase were in parallel with a significant increase level of interleukin-6 (IL-6) in the serum.
Negative_regulation (were) of Positive_regulation (increase) of interleukin-6 in spikes associated with anesthesia and infection
17) Confidence 0.37 Published 2010 Journal Neuroscience Section Abstract Doc Link 19892004 Disease Relevance 1.47 Pain Relevance 0.18
Perineural clonidine, but not saline, partially reversed the hypersensitivity, accompanied by reduced concentrations of interleukin 6 and interleukin 1beta in the sciatic nerve.
Negative_regulation (reduced) of Positive_regulation (concentrations) of interleukin 6 in sciatic nerve
18) Confidence 0.36 Published 2006 Journal Anesthesiology Section Body Doc Link 16436856 Disease Relevance 0.08 Pain Relevance 0
Exposure of neonatal rat cortical microglial cells to the exogenous cannabinoid delta(9)-tetrahydrocannabinol (THC) resulted in reduced amounts of lipopolysaccharide (LPS)-induced mRNAs for IL-1alpha, IL-1beta, IL-6, and TNF-alpha.
Negative_regulation (reduced) of Positive_regulation (induced) of IL-6 in microglial cells associated with cannabinoid
19) Confidence 0.32 Published 2000 Journal Glia Section Abstract Doc Link 10594923 Disease Relevance 0 Pain Relevance 0.41
Treatment with any one of the three sympatholytics abolished the upregulation of NGF and IL-6, while phentolamine and guanethedine also reversed the upregulation of TNF-alpha.
Negative_regulation (abolished) of Positive_regulation (upregulation) of IL-6 associated with nerve growth factor
20) Confidence 0.26 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12015213 Disease Relevance 0.95 Pain Relevance 0.98

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