INT4940

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Context Info
Confidence 0.37
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 8
Total Number 8
Disease Relevance 4.29
Pain Relevance 8.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tacr1) response to stress (Tacr1) cytoplasm (Tacr1)
signal transducer activity (Tacr1)
Anatomy Link Frequency
spinal cord 6
dorsal root ganglion 4
Spinal 2
nucleus 2
celiac ganglion 2
Tacr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 39 100.00 Very High Very High Very High
Spinal cord 15 100.00 Very High Very High Very High
qutenza 7 100.00 Very High Very High Very High
Neurotransmitter 4 100.00 Very High Very High Very High
Hyperalgesia 3 100.00 Very High Very High Very High
Calcitonin gene-related peptide 1 100.00 Very High Very High Very High
Morphine 18 99.98 Very High Very High Very High
Nerve growth factor 1 99.80 Very High Very High Very High
Enkephalin 3 99.72 Very High Very High Very High
intrathecal 6 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 5 100.00 Very High Very High Very High
Ganglion Cysts 7 99.98 Very High Very High Very High
Pancreatitis 7 98.60 Very High Very High Very High
Injury 8 98.32 Very High Very High Very High
Neuropathic Pain 5 98.04 Very High Very High Very High
Nociception 3 96.64 Very High Very High Very High
Pox Virus Infection 1 93.16 High High
Pain 6 92.84 High High
Cervical Cancer 3 91.16 High High
Hypersensitivity 1 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.
Negative_regulation (inhibits) of Localization (release) of substance P in spinal cord associated with antinociception, nociceptor, calcium channel, spinal cord, substance p and intrathecal
1) Confidence 0.37 Published 2002 Journal Pain Section Title Doc Link 11932068 Disease Relevance 0.23 Pain Relevance 1.23
Spinal opiate analgesia is associated with presynaptic inhibition of release of excitatory neurotransmitters/neuromodulators, e.g., substance P (SP), from primary afferent terminals.
Negative_regulation (inhibition) of Localization (release) of substance P in Spinal associated with neurotransmitter, opiate, substance p and analgesia
2) Confidence 0.33 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15908510 Disease Relevance 0 Pain Relevance 1.18
Local disruption of the celiac ganglion inhibits substance P release and ameliorates caerulein-induced pancreatitis in rats.
Negative_regulation (inhibits) of Localization (release) of substance P in celiac ganglion associated with ganglion cysts, pancreatitis and substance p
3) Confidence 0.31 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 16769810 Disease Relevance 1.12 Pain Relevance 0.57
In the iris sphincter muscle of the rabbit and in dorsal root ganglion cells (DRG) of the rat, inhibition of the release of substance P by BoNT-A has been shown experimentally, and BoNT-C has been proven to develop endopeptidase activity toward substance P (SP) in vitro.
Negative_regulation (inhibition) of Localization (release) of substance P in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and substance p
4) Confidence 0.30 Published 2001 Journal Nervenarzt Section Abstract Doc Link 11320866 Disease Relevance 0.92 Pain Relevance 0.75
NK3 receptor blockade prevents hyperalgesia and the associated spinal cord substance P release in monoarthritic rats.
Negative_regulation (prevents) of Localization (release) of substance P in spinal cord associated with hyperalgesia, inflammation, substance p and spinal cord
5) Confidence 0.09 Published 2000 Journal Neuropharmacology Section Title Doc Link 10665827 Disease Relevance 0.41 Pain Relevance 1.03
In vitro, BCTC inhibited capsaicin (300 nM)-induced releases of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) and substance P-like immunoreactivity (SP-LI) from the rat spinal cord slice preparations with IC(50)s of 37.0 and 36.0 nM, respectively, confirming that BCTC potently inhibits TRPV1 function in the rat spinal cord.
Negative_regulation (inhibited) of Localization (releases) of substance P-like immunoreactivity in spinal cord associated with qutenza, spinal cord, substance p and calcitonin gene-related peptide
6) Confidence 0.08 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15998524 Disease Relevance 0.98 Pain Relevance 1.29
Neurotropin inhibits both capsaicin-induced substance P release and nerve growth factor-induced neurite outgrowth in cultured rat dorsal root ganglion neurones.
Negative_regulation (inhibits) of Localization (release) of substance P in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, nerve growth factor, qutenza and substance p
7) Confidence 0.07 Published 2010 Journal Clin. Exp. Dermatol. Section Title Doc Link 19874332 Disease Relevance 0.63 Pain Relevance 0.52
Delta-opioid-receptor activation by [D-Pen2,D-Pen5]enkephalin and morphine inhibits substance P release from trigeminal nucleus slices.
Negative_regulation (inhibits) of Localization (release) of substance P in nucleus associated with analgesic, enkephalin, opioid, substance p and morphine
8) Confidence 0.06 Published 1992 Journal Eur. J. Pharmacol. Section Title Doc Link 1282103 Disease Relevance 0 Pain Relevance 1.67

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