INT49402

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Context Info
Confidence 0.61
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 4.23
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (EDA) cell differentiation (EDA) signal transduction (EDA)
extracellular region (EDA) plasma membrane (EDA) cytoskeleton (EDA)
Anatomy Link Frequency
blood 2
joints 2
articular 1
hepatic vein 1
parietal 1
EDA (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 19 99.70 Very High Very High Very High
dorsal root ganglion 46 98.96 Very High Very High Very High
Inflammation 182 98.84 Very High Very High Very High
Pain 16 96.28 Very High Very High Very High
Osteoarthritis 2 95.04 Very High Very High Very High
medulla 1 79.00 Quite High
halothane 1 76.64 Quite High
cytokine 29 76.32 Quite High
Paracetamol 2 71.84 Quite High
Autonomic response 1 68.96 Quite High
Disease Link Frequency Relevance Heat
Shock 9 100.00 Very High Very High Very High
Rheumatoid Arthritis 19 99.70 Very High Very High Very High
Arthritis 38 99.08 Very High Very High Very High
Ganglion Cysts 46 98.96 Very High Very High Very High
INFLAMMATION 185 97.12 Very High Very High Very High
Arthralgia 1 96.52 Very High Very High Very High
Polymyositis 1 95.64 Very High Very High Very High
Osteoarthritis 2 95.04 Very High Very High Very High
Systemic Lupus Erythematosus 13 94.96 High High
Disease 75 93.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: In 20 patients under general anesthesia, we assessed hepatic blood flow index in the right and middle hepatic vein by use of multiplane transesophageal echocardiography before and after induction of EDA.
Positive_regulation (induction) of EDA in hepatic vein
1) Confidence 0.61 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19299808 Disease Relevance 0 Pain Relevance 0
Norepinephrine (NE) was continuously administered to patients who demonstrated a decrease in mean arterial blood pressure below 60 mm Hg after induction of EDA (EDA-NE group).
Positive_regulation (induction) of EDA in blood
2) Confidence 0.61 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19299808 Disease Relevance 0 Pain Relevance 0
The patients with rheumatoid arthritis showed a high level of EDA(+) FN in their plasma, and the EDA(+) FN level in plasma corresponded with changes in joint pain.
Positive_regulation (level) of EDA in joint associated with pain, arthralgia and rheumatoid arthritis
3) Confidence 0.49 Published 1994 Journal Int J Artif Organs Section Abstract Doc Link 7896431 Disease Relevance 0.48 Pain Relevance 0.19
Intra-articular injection of the TLR4 activators FNEDA or tenascin-C induces joint inflammation in wild type but not in TLR4 null mice [24, 86].
Positive_regulation (activators) of EDA in articular associated with inflammation and arthritis
4) Confidence 0.49 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.57 Pain Relevance 0.48
For example, a wide range of endogenous TLR activators, including heat shock proteins, HMGB1, host DNA, fibrinogen, FNEDA, and tenascin-C, are observed in synovia of RA patients but not in synovia from normal joints or non-inflamed synovia from osteoarthritis (OA) patients [106–112].
Positive_regulation (activators) of EDA in joints associated with shock, rheumatoid arthritis and osteoarthritis
5) Confidence 0.45 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.18 Pain Relevance 0.24
Results are interpreted as indicating that fronto-parietal control of EDA is probably mediated by a double descending system: one involving corticoreticulospinal pathways and a direct corticospinal one.
Spec (probably) Positive_regulation (mediated) of EDA in parietal
6) Confidence 0.43 Published 1995 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 7560747 Disease Relevance 0.07 Pain Relevance 0.11
Norepinephrine (NE) was continuously administered to patients who demonstrated a decrease in mean arterial blood pressure below 60 mm Hg after induction of EDA (EDA-NE group).
Positive_regulation (induction) of EDA-NE in blood
7) Confidence 0.41 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19299808 Disease Relevance 0 Pain Relevance 0
A less marked increase in ED1-positive cell numbers was observed in the contralateral DRG, reaching statistical significance only at 7 days.
Positive_regulation (increase) of ED1 associated with dorsal root ganglion
8) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 0.91 Pain Relevance 0.40

General Comments

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